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GOLM1 golgi membrane protein 1 [ Homo sapiens (human) ]

Gene ID: 51280, updated on 13-Dec-2020

Summary

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Official Symbol
GOLM1provided by HGNC
Official Full Name
golgi membrane protein 1provided by HGNC
Primary source
HGNC:HGNC:15451
See related
Ensembl:ENSG00000135052 MIM:606804
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GP73; HEL46; GOLPH2; C9orf155; PSEC0257; bA379P1.3
Summary
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi transmembrane protein. It processes proteins synthesized in the rough endoplasmic reticulum and assists in the transport of protein cargo through the Golgi apparatus. The expression of this gene has been observed to be upregulated in response to viral infection. Alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Sep 2009]
Expression
Broad expression in stomach (RPKM 210.4), colon (RPKM 117.5) and 14 other tissues See more
Orthologs
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Genomic context

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See GOLM1 in Genome Data Viewer
Location:
9q21.33
Exon count:
11
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (86026146..86100149, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (88629018..88715116, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene prohibitin pseudogene 7 Neighboring gene ribosomal L1 domain-containing protein 1-like Neighboring gene N-alpha-acetyltransferase 35, NatC auxiliary subunit Neighboring gene uncharacterized LOC101927623 Neighboring gene chromosome 4 open reading frame 3 pseudogene Neighboring gene chromosome 9 open reading frame 153 Neighboring gene RN7SK pseudogene 264

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Serum Golgi Protein 73 as a Potential Biomarker for Hepatic Necroinflammation in Population with Nonalcoholic Steatohepatitis. Wang L, et al. Dis Markers, 2020. PMID 32089754, Free PMC Article
  2. Exploring the Diagnostic Potential of Serum Golgi Protein 73 for Hepatic Necroinflammation and Fibrosis in Chronic HCV Infection with Different Stages of Liver Injuries. Qian X, et al. Dis Markers, 2019. PMID 31636735, Free PMC Article
  3. Serum GP73 predicts posthepatectomy outcomes in patients with hepatocellular carcinoma. Ke MY, et al. J Transl Med, 2019 May 2. PMID 31046807, Free PMC Article
  4. GOLM1 silencing inhibits the proliferation and motility of human glioblastoma cells via the Wnt/β-catenin signaling pathway. Ding X, et al. Brain Res, 2019 Aug 15. PMID 30935831
  5. GP73, a novel TGF-β target gene, provides selective regulation on Smad and non-Smad signaling pathways. Yang X, et al. Biochim Biophys Acta Mol Cell Res, 2019 Apr. PMID 30615900

See all (132) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Targeting GOLM1 by microRNA-200a in melanoma suppresses cell proliferation, invasion and migration via regulating PI3K/Akt signaling pathway and epithelial-mesenchymal transition.
    Title: Targeting GOLM1 by microRNA-200a in melanoma suppresses cell proliferation, invasion and migration via regulating PI3K/Akt signaling pathway and epithelial-mesenchymal transition.
  2. Serum Golgi Protein 73 as a Potential Biomarker for Hepatic Necroinflammation in Population with Nonalcoholic Steatohepatitis.
    Title: Serum Golgi Protein 73 as a Potential Biomarker for Hepatic Necroinflammation in Population with Nonalcoholic Steatohepatitis.
  3. GOLM1 silencing inhibits the proliferation and motility of human glioblastoma cells via the Wnt/beta-catenin signaling pathway.
    Title: GOLM1 silencing inhibits the proliferation and motility of human glioblastoma cells via the Wnt/β-catenin signaling pathway.
  4. Clinicopathological significance of miR-27b targeting Golgi protein 73 in patients with hepatocellular carcinoma.
    Title: Clinicopathological significance of miR-27b targeting Golgi protein 73 in patients with hepatocellular carcinoma.
  5. This study reveals that GP73 plays functional roles in the trafficking and equilibrium of epithelial-mesenchymal transition (EMT)-related secretory proteins and that GP73 serves as a new potential target for combating the metastasis of hepatocellular carcinoma (HCC) .
    Title: Knockdown of Golgi phosphoprotein 73 blocks the trafficking of matrix metalloproteinase-2 in hepatocellular carcinoma cells and inhibits cell invasion.
  6. salivary exosomal GOLM1-NAA35 chimeric RNA (seG-NchiRNA) constitutes an effective candidate noninvasive biomarker for the convenient, reliable assessment of therapeutic response, recurrence, and early detection.
    Title: Evaluation of Salivary Exosomal Chimeric <i>GOLM1-NAA35</i> RNA as a Potential Biomarker in Esophageal Carcinoma.
  7. mTOR/miR-145-regulated exosomal GOLM1 promotes hepatocellular carcinoma through augmented GSK-3beta/MMPs
    Title: mTOR/miR-145-regulated exosomal GOLM1 promotes hepatocellular carcinoma through augmented GSK-3β/MMPs.
  8. Authors report that GOLM1 is over-expressed in GC and knockdown GOLM1 impairs the aggressive phenotypes of GC cell in vitro.
    Title: Identification of GOLM1 as a positively regulator of tumor metastasis by regulating MMP13 in gastric carcinoma.
  9. Serum GP73 is a useful tool to stratify hepatocellular carcinoma patients and to predict short-term outcomes after hepatectomy.
    Title: Serum GP73 predicts posthepatectomy outcomes in patients with hepatocellular carcinoma.
  10. Serum GP73 is an important biomarker in evaluating and monitoring disease progression of liver necroinflammation and fibrosis in patients with chronic HCV infection, but the value is limited for diagnosing advanced fibrosis and cirrhosis in comparison with APRI and FIB-4
    Title: Exploring the Diagnostic Potential of Serum Golgi Protein 73 for Hepatic Necroinflammation and Fibrosis in Chronic HCV Infection with Different Stages of Liver Injuries.
Submit: New GeneRIF Correction See all GeneRIFs (105)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of golgi membrane protein 1 (GOLM1; C9orf155) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ22634, FLJ23608

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
cellular protein metabolic process TAS
Traceable Author Statement
more info
  
nucleus organization IEA
Inferred from Electronic Annotation
more info
  
post-translational protein modification TAS
Traceable Author Statement
more info
  
regulation of lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
  
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
  
extracellular space HDA PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
Golgi membrane protein 1
Names
epididymis luminal protein 46
golgi membrane protein GP73
golgi phosphoprotein 2
golgi protein, 73-kD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016548.4 → NP_057632.2  Golgi membrane protein 1

    See identical proteins and their annotated locations for NP_057632.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK027717, AL533767, BC001740
    Consensus CDS
    CCDS35054.1
    UniProtKB/Swiss-Prot
    Q8NBJ4
    UniProtKB/TrEMBL
    B3KNK9
    Related
    ENSP00000373364.3, ENST00000388712.7
    Conserved Domains (1) summary
    TIGR02169
    Location:41 → 211
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  2. NM_177937.3 → NP_808800.1  Golgi membrane protein 1

    See identical proteins and their annotated locations for NP_808800.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK075557, BC001740, DA116177
    Consensus CDS
    CCDS35054.1
    UniProtKB/Swiss-Prot
    Q8NBJ4
    UniProtKB/TrEMBL
    B3KNK9
    Related
    ENSP00000373363.3, ENST00000388711.7
    Conserved Domains (1) summary
    TIGR02169
    Location:41 → 211
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    86026146..86100149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001099268.1: Suppressed sequence

    Description
    NM_001099268.1: This RefSeq was permanently suppressed because it is primarily intronic sequence.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NBJ4.1 GenPept UniProtKB/Swiss-Prot:Q8NBJ4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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