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GOLM1 golgi membrane protein 1 [ Homo sapiens (human) ]

Gene ID: 51280, updated on 21-Dec-2019

Summary

Official Symbol
GOLM1provided by HGNC
Official Full Name
golgi membrane protein 1provided by HGNC
Primary source
HGNC:HGNC:15451
See related
Ensembl:ENSG00000135052 MIM:606804
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GP73; HEL46; GOLPH2; C9orf155; PSEC0257; bA379P1.3
Summary
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi transmembrane protein. It processes proteins synthesized in the rough endoplasmic reticulum and assists in the transport of protein cargo through the Golgi apparatus. The expression of this gene has been observed to be upregulated in response to viral infection. Alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Sep 2009]
Expression
Broad expression in stomach (RPKM 210.4), colon (RPKM 117.5) and 14 other tissues See more
Orthologs

Genomic context

See GOLM1 in Genome Data Viewer
Location:
9q21.33
Exon count:
11
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (86026141..86100201, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (88629018..88715116, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene prohibitin pseudogene 7 Neighboring gene ribosomal L1 domain-containing protein 1-like Neighboring gene N-alpha-acetyltransferase 35, NatC auxiliary subunit Neighboring gene uncharacterized LOC101927623 Neighboring gene chromosome 4 open reading frame 3 pseudogene Neighboring gene chromosome 9 open reading frame 153 Neighboring gene RN7SK pseudogene 264

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of golgi membrane protein 1 (GOLM1; C9orf155) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22634, FLJ23608

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
nucleus organization IEA
Inferred from Electronic Annotation
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
regulation of lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular space HDA PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
Golgi membrane protein 1
Names
epididymis luminal protein 46
golgi membrane protein GP73
golgi phosphoprotein 2
golgi protein, 73-kD

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016548.4NP_057632.2  Golgi membrane protein 1

    See identical proteins and their annotated locations for NP_057632.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK027717, AL533767, BC001740
    Consensus CDS
    CCDS35054.1
    UniProtKB/Swiss-Prot
    Q8NBJ4
    UniProtKB/TrEMBL
    B3KNK9
    Related
    ENSP00000373364.3, ENST00000388712.7
    Conserved Domains (1) summary
    TIGR02169
    Location:41211
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
  2. NM_177937.2NP_808800.1  Golgi membrane protein 1

    See identical proteins and their annotated locations for NP_808800.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK075557, BC001740, CA446701, DA116177
    Consensus CDS
    CCDS35054.1
    UniProtKB/Swiss-Prot
    Q8NBJ4
    UniProtKB/TrEMBL
    B3KNK9
    Related
    ENSP00000373363.3, ENST00000388711.7
    Conserved Domains (1) summary
    TIGR02169
    Location:41211
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    86026141..86100201 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001099268.1: Suppressed sequence

    Description
    NM_001099268.1: This RefSeq was permanently suppressed because it is primarily intronic sequence.
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