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GOLM1 golgi membrane protein 1 [ Homo sapiens (human) ]

Gene ID: 51280, updated on 21-Dec-2019

Summary

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Official Symbol
GOLM1provided by HGNC
Official Full Name
golgi membrane protein 1provided by HGNC
Primary source
HGNC:HGNC:15451
See related
Ensembl:ENSG00000135052 MIM:606804
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GP73; HEL46; GOLPH2; C9orf155; PSEC0257; bA379P1.3
Summary
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi transmembrane protein. It processes proteins synthesized in the rough endoplasmic reticulum and assists in the transport of protein cargo through the Golgi apparatus. The expression of this gene has been observed to be upregulated in response to viral infection. Alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Sep 2009]
Expression
Broad expression in stomach (RPKM 210.4), colon (RPKM 117.5) and 14 other tissues See more
Orthologs
mouse all

Genomic context

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See GOLM1 in Genome Data Viewer
Location:
9q21.33
Exon count:
11
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (86026141..86100201, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (88629018..88715116, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene prohibitin pseudogene 7 Neighboring gene ribosomal L1 domain-containing protein 1-like Neighboring gene N-alpha-acetyltransferase 35, NatC auxiliary subunit Neighboring gene uncharacterized LOC101927623 Neighboring gene chromosome 4 open reading frame 3 pseudogene Neighboring gene chromosome 9 open reading frame 153 Neighboring gene RN7SK pseudogene 264

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. GP73, a novel TGF-β target gene, provides selective regulation on Smad and non-Smad signaling pathways. Yang X, et al. Biochim Biophys Acta Mol Cell Res, 2019 Apr. PMID 30615900
  2. Clinical significance and expression of serum Golgi protein 73 in primary hepatocellular carcinoma. Jiao C, et al. J Cancer Res Ther, 2018 Oct-Dec. PMID 30488837
  3. Serum Golgi protein 73 is a marker comparable to APRI for diagnosing significant fibrosis in children with liver disease. Liu L, et al. Sci Rep, 2018 Nov 13. PMID 30425268, Free PMC Article
  4. Golgi protein 73 and its diagnostic value in liver diseases. Xia Y, et al. Cell Prolif, 2019 Mar. PMID 30341783
  5. Overexpression of GP73 promotes cell invasion, migration and metastasis by inducing epithelial-mesenchymal transition in pancreatic cancer. Song YX, et al. Pancreatology, 2018 Oct. PMID 30217697

See all (119) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. serum GP73 is comparable to APRI for diagnosing significant fibrosis in children
    Title: Serum Golgi protein 73 is a marker comparable to APRI for diagnosing significant fibrosis in children with liver disease.
  2. The associations between Golgi membrane protein 73 (GP73) /transforming growth factor beta 1 (TGF-beta1)/SMAD2 protein (Smad2) and the clinic pathological features of patients with bladder cancer were explored.
    Title: GP73 promotes invasion and metastasis of bladder cancer by regulating the epithelial-mesenchymal transition through the TGF-β1/Smad2 signalling pathway.
  3. These findings support GOLM1 as a candidate melanoma predisposition gene
    Title: A Nonsynonymous Variant in the GOLM1 Gene in Cutaneous Malignant Melanoma.
  4. GP73 is a direct target of TGF-beta1 transcriptional regulation. Its induced expression inhibits TGF-beta-Smad mediated growth suppression. On the other hand, elevated GP73 results in upregulation of ERK/Akt signaling induced by TGF-beta1.
    Title: GP73, a novel TGF-β target gene, provides selective regulation on Smad and non-Smad signaling pathways.
  5. GP73 is indispensable for SREBPs activation and lipogenesis. Notably, GP73 overexpression enhanced SCAP-SREBP1 binding and its Golgi trafficking even under cholesterol sufficiency.
    Title: GP73 regulates Hepatic Steatosis by enhancing SCAP-SREBPs interaction.
  6. serum level significantly higher in hepatocellular carcinoma patients compared to cirrhosis patients
    Title: The Value of GPC3 and GP73 in Clinical Diagnosis of Hepatocellular Carcinoma.
  7. GOLPH2 is a potential marker for estimating the patient's prognosis and may be a target for molecular-targeted therapy against oral squamous cell carcinoma (OSCC).
    Title: Overexpression of Golgi Phosphoprotein 2 Is Associated With Poor Prognosis in Oral Squamous Cell Carcinoma.
  8. This article reviewed the discovery history of GP73 and summarized studies by many groups around the world, aiming at understanding its structure, expression, function, detection methods and the relationship between GP73 and liver diseases in various settings. [review]
    Title: Golgi protein 73 and its diagnostic value in liver diseases.
  9. Overexpressing of GOLM1 markedly promoted the tumorigenicity and metastasis of BC cells in vivo, whereas knock-down of GOLM1 caused the opposite outcomes. Results proved that GOLM1 promoted BC cell aggressiveness by regulating matrix metalloproteinase-13 (MMP13).
    Title: Golgi Membrane Protein 1 (GOLM1) Promotes Growth and Metastasis of Breast Cancer Cells via Regulating Matrix Metalloproteinase-13 (MMP13).
  10. High serum GP73 expression is associated with hepatocellular carcinoma.
    Title: Clinical significance and expression of serum Golgi protein 73 in primary hepatocellular carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (94)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of golgi membrane protein 1 (GOLM1; C9orf155) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ22634, FLJ23608

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
cellular protein metabolic process TAS
Traceable Author Statement
more info
  
nucleus organization IEA
Inferred from Electronic Annotation
more info
  
post-translational protein modification TAS
Traceable Author Statement
more info
  
regulation of lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
  
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
  
extracellular space HDA PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
Golgi membrane protein 1
Names
epididymis luminal protein 46
golgi membrane protein GP73
golgi phosphoprotein 2
golgi protein, 73-kD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016548.4 → NP_057632.2  Golgi membrane protein 1

    See identical proteins and their annotated locations for NP_057632.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK027717, AL533767, BC001740
    Consensus CDS
    CCDS35054.1
    UniProtKB/Swiss-Prot
    Q8NBJ4
    UniProtKB/TrEMBL
    B3KNK9
    Related
    ENSP00000373364.3, ENST00000388712.7
    Conserved Domains (1) summary
    TIGR02169
    Location:41 → 211
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  2. NM_177937.2 → NP_808800.1  Golgi membrane protein 1

    See identical proteins and their annotated locations for NP_808800.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK075557, BC001740, CA446701, DA116177
    Consensus CDS
    CCDS35054.1
    UniProtKB/Swiss-Prot
    Q8NBJ4
    UniProtKB/TrEMBL
    B3KNK9
    Related
    ENSP00000373363.3, ENST00000388711.7
    Conserved Domains (1) summary
    TIGR02169
    Location:41 → 211
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    86026141..86100201 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001099268.1: Suppressed sequence

    Description
    NM_001099268.1: This RefSeq was permanently suppressed because it is primarily intronic sequence.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NBJ4.1 GenPept UniProtKB/Swiss-Prot:Q8NBJ4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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