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C1RL complement C1r subcomponent like [ Homo sapiens (human) ]

Gene ID: 51279, updated on 18-Aug-2020

Summary

Official Symbol
C1RLprovided by HGNC
Official Full Name
complement C1r subcomponent likeprovided by HGNC
Primary source
HGNC:HGNC:21265
See related
Ensembl:ENSG00000139178 MIM:608974
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C1RL1; C1RLP; CLSPa; C1r-LP
Expression
Ubiquitous expression in liver (RPKM 37.4), adrenal (RPKM 16.4) and 22 other tissues See more
Orthologs

Genomic context

See C1RL in Genome Data Viewer
Location:
12p13.31
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (7094554..7109214, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (7246000..7261869, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene complement C1s Neighboring gene complement C1r Neighboring gene C1RL antisense RNA 1 Neighboring gene RNA, U6 small nuclear 485, pseudogene Neighboring gene retinol binding protein 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of complement component 1, r subcomponent-like (C1RL) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: C1R

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
complement activation, classical pathway IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
zymogen activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
blood microparticle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular space HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
complement C1r subcomponent-like protein
Names
C1r-like protein
C1r-like serine protease analog protein
complement C1r-like proteinase
complement component 1, r subcomponent-like
NP_001284569.1
NP_001284571.1
NP_001284572.1
NP_057630.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297640.2NP_001284569.1  complement C1r subcomponent-like protein isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC233309, AK222802, DR004214, HY062376
    UniProtKB/Swiss-Prot
    Q9NZP8
    Conserved Domains (3) summary
    smart00020
    Location:205437
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:40162
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00190
    Location:205438
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. NM_001297642.2NP_001284571.1  complement C1r subcomponent-like protein isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR, and uses an alternate splice site in the 5' coding region resulting in a frameshift, compared to variant 1. The encoded isoform (3) is shorter, and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC233309, AK314299
    Consensus CDS
    CCDS73431.1
    UniProtKB/TrEMBL
    F5GWF3
    Related
    ENSP00000441885.1, ENST00000544702.5
    Conserved Domains (1) summary
    cd00041
    Location:40162
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
  3. NM_001297643.2NP_001284572.1  complement C1r subcomponent-like protein isoform 4 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (4) is shorter, and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AW450562, BC062428, HY062376
    Consensus CDS
    CCDS76517.1
    UniProtKB/TrEMBL
    F5H7C8, Q6P672
    Related
    ENSP00000442611.1, ENST00000545337.1
    Conserved Domains (1) summary
    cd00041
    Location:40162
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
  4. NM_016546.4NP_057630.2  complement C1r subcomponent-like protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_057630.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC233309, AK222802, HY062376
    Consensus CDS
    CCDS8573.1
    UniProtKB/Swiss-Prot
    Q9NZP8
    Related
    ENSP00000266542.4, ENST00000266542.9
    Conserved Domains (3) summary
    smart00020
    Location:247479
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:40162
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00190
    Location:247480
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    7094554..7109214 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_021160008.1 Reference GRCh38.p13 PATCHES

    Range
    22240..36900 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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