Format

Send to:

Choose Destination

IER5 immediate early response 5 [ Homo sapiens (human) ]

Gene ID: 51278, updated on 21-Dec-2019

Summary

Official Symbol
IER5provided by HGNC
Official Full Name
immediate early response 5provided by HGNC
Primary source
HGNC:HGNC:5393
See related
Ensembl:ENSG00000162783 MIM:607177
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SBBI48
Summary
This gene encodes a protein that is similar to other immediate early response proteins. In the mouse, a similar gene may play an important role in mediating the cellular response to mitogenic signals. Studies in rats found the expression of a similar gene to be increased after waking and sleep deprivation. [provided by RefSeq, Jul 2008]
Orthologs

Genomic context

See IER5 in Genome Data Viewer
Location:
1q25.3
Exon count:
1
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (181088700..181092900)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (181057638..181059979)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene syntaxin 6 Neighboring gene major histocompatibility complex, class I-related Neighboring gene CRISPRi-validated cis-regulatory element chr1.10177 Neighboring gene VISTA enhancer hs1862

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102760

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to heat IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cellular response to heat IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with protein phosphatase type 2A complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
immediate early response gene 5 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016545.5NP_057629.2  immediate early response gene 5 protein

    See identical proteins and their annotated locations for NP_057629.2

    Status: VALIDATED

    Source sequence(s)
    AA235294, AF178984, AI696140, AL356267
    Consensus CDS
    CCDS1343.1
    UniProtKB/Swiss-Prot
    Q5VY09
    Related
    ENSP00000356549.4, ENST00000367577.7
    Conserved Domains (1) summary
    pfam05760
    Location:1327
    IER; Immediate early response protein (IER)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    181088700..181092900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center