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FLT3 fms related receptor tyrosine kinase 3 [ Bos taurus (domestic cattle) ]

Gene ID: 512700, updated on 30-Jan-2025
Official Symbol
FLT3provided by VGNC
Official Full Name
fms related receptor tyrosine kinase 3provided by VGNC
Primary source
VGNC:VGNC:29042
See related
BGD:BT25776; EnsemblRapid:ENSBTAG00070007964
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See FLT3 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 12 NC_037339.1 (31990104..32060002)

Chromosome 12 - NC_037339.1Genomic Context describing neighboring genes Neighboring gene fms related receptor tyrosine kinase 1 Neighboring gene microRNA mir-2300a Neighboring gene microRNA mir-2300b Neighboring gene poly(A) specific ribonuclease subunit PAN3 Neighboring gene centromere-associated protein E-like Neighboring gene microRNA mir-2285o-2 Neighboring gene ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase Neighboring gene caudal type homeobox 2

Genomic Sequence:
NC_037339.1 Chromosome 12 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
receptor-type tyrosine-protein kinase FLT3
Names
fms related tyrosine kinase 3
XP_024855842.1
XP_024855843.1
XP_024855844.1

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RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037339.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    31990104..32060002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025000075.2 → XP_024855843.1  receptor-type tyrosine-protein kinase FLT3 isoform X2

    UniProtKB/TrEMBL
    F1MRU0
    Conserved Domains (3) summary
    pfam00047
    Location:237 → 326
    ig; Immunoglobulin domain
    cl11960
    Location:61 → 142
    Ig; Immunoglobulin domain
    cl21453
    Location:553 → 928
    PKc_like; Protein Kinases, catalytic domain

  2. XM_025000076.2 → XP_024855844.1  receptor-type tyrosine-protein kinase FLT3 isoform X3

    UniProtKB/TrEMBL
    F1MRU0
    Related
    ENSBTAP00070010481.1, ENSBTAT00070017954.1
    Conserved Domains (3) summary
    pfam00047
    Location:256 → 345
    ig; Immunoglobulin domain
    cl11960
    Location:80 → 161
    Ig; Immunoglobulin domain
    cl21453
    Location:572 → 912
    PKc_like; Protein Kinases, catalytic domain

  3. XM_025000074.2 → XP_024855842.1  receptor-type tyrosine-protein kinase FLT3 isoform X1

    UniProtKB/TrEMBL
    A0AAA9TE98, F1MRU0
    Related
    ENSBTAP00070010463.1, ENSBTAT00070017929.1
    Conserved Domains (3) summary
    pfam00047
    Location:256 → 345
    ig; Immunoglobulin domain
    cl11960
    Location:80 → 161
    Ig; Immunoglobulin domain
    cl21453
    Location:572 → 947
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
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