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PIPOX pipecolic acid and sarcosine oxidase [ Homo sapiens (human) ]

Gene ID: 51268, updated on 18-Aug-2020

Summary

Official Symbol
PIPOXprovided by HGNC
Official Full Name
pipecolic acid and sarcosine oxidaseprovided by HGNC
Primary source
HGNC:HGNC:17804
See related
Ensembl:ENSG00000179761 MIM:616713
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LPIPOX
Expression
Biased expression in liver (RPKM 113.3) and kidney (RPKM 56.6) See more
Orthologs

Genomic context

See PIPOX in Genome Data Viewer
Location:
17q11.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (29043141..29057227)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (27369918..27384245)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371716 Neighboring gene seizure related 6 homolog Neighboring gene NADH:ubiquinone oxidoreductase subunit S5 pseudogene 7 Neighboring gene myosin XVIIIA Neighboring gene TGFB1-induced anti-apoptotic factor 1 Neighboring gene gap junction protein alpha 4 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
L-pipecolate oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
L-pipecolate oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
L-pipecolate oxidase activity NAS
Non-traceable Author Statement
more info
PubMed 
L-pipecolate oxidase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sarcosine oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sarcosine oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
L-lysine catabolic process to acetyl-CoA via L-pipecolate IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
L-lysine catabolic process to acetyl-CoA via L-pipecolate IDA
Inferred from Direct Assay
more info
PubMed 
lysine catabolic process TAS
Traceable Author Statement
more info
 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
protein targeting to peroxisome TAS
Traceable Author Statement
more info
 
tetrahydrofolate metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
peroxisomal matrix TAS
Traceable Author Statement
more info
 
peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peroxisome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
peroxisomal sarcosine oxidase
Names
L-pipecolate oxidase
L-pipecolic acid oxidase
PSO
pipecolic acid oxidase
NP_057602.2
XP_016880211.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016518.3NP_057602.2  peroxisomal sarcosine oxidase

    See identical proteins and their annotated locations for NP_057602.2

    Status: VALIDATED

    Source sequence(s)
    AF134593, BC008960
    Consensus CDS
    CCDS11248.1
    UniProtKB/Swiss-Prot
    Q9P0Z9
    Related
    ENSP00000317721.4, ENST00000323372.9
    Conserved Domains (2) summary
    TIGR01377
    Location:8388
    soxA_mon; sarcosine oxidase, monomeric form
    pfam13450
    Location:1238
    NAD_binding_8; NAD(P)-binding Rossmann-like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    29043141..29057227
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024722.1XP_016880211.1  peroxisomal sarcosine oxidase isoform X1

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