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CLEC1B C-type lectin domain family 1 member B [ Homo sapiens (human) ]

Gene ID: 51266, updated on 8-Dec-2018

Summary

Official Symbol
CLEC1Bprovided by HGNC
Official Full Name
C-type lectin domain family 1 member Bprovided by HGNC
Primary source
HGNC:HGNC:24356
See related
Ensembl:ENSG00000165682 MIM:606783
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLEC2; CLEC2B; PRO1384; QDED721; 1810061I13Rik
Summary
Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011]
Expression
Biased expression in liver (RPKM 4.2), bone marrow (RPKM 0.6) and 1 other tissue See more
Orthologs

Genomic context

See CLEC1B in Genome Data Viewer
Location:
12p13.31-p13.2
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (9986119..10001894, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (10145660..10153381, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2470 Neighboring gene CLEC12A antisense RNA 1 Neighboring gene C-type lectin domain family 12 member A Neighboring gene C-type lectin domain family 12 member B Neighboring gene uncharacterized LOC102724020 Neighboring gene uncharacterized LOC112268091 Neighboring gene C-type lectin domain family 1 member B pseudogene Neighboring gene C-type lectin domain containing 9A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • GPVI-mediated activation cascade, organism-specific biosystem (from REACTOME)
    GPVI-mediated activation cascade, organism-specific biosystemThe GPVI receptor is a complex of the GPVI protein with Fc epsilon R1 gamma (FcR). The Src family kinases Fyn and Lyn constitutively associate with the GPVI-FcR complex in platelets and initiate plat...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
    Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
defense response TAS
Traceable Author Statement
more info
PubMed 
platelet activation TAS
Traceable Author Statement
more info
 
platelet formation IEA
Inferred from Electronic Annotation
more info
 
signal transduction by protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
C-type lectin domain family 1 member B
Names
C-type lectin-like receptor 2
CLEC-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099431.1NP_001092901.1  C-type lectin domain family 1 member B isoform b

    See identical proteins and their annotated locations for NP_001092901.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AC091814, AY358599, BC029554
    Consensus CDS
    CCDS41751.1
    UniProtKB/Swiss-Prot
    Q9P126
    Related
    ENSP00000327169.6, ENST00000348658.4
    Conserved Domains (1) summary
    cd03593
    Location:69185
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
  2. NM_016509.3NP_057593.3  C-type lectin domain family 1 member B isoform a

    See identical proteins and their annotated locations for NP_057593.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC091814, AY358599, BC029554
    Consensus CDS
    CCDS41752.1
    UniProtKB/Swiss-Prot
    Q9P126
    Related
    ENSP00000298527.6, ENST00000298527.10
    Conserved Domains (1) summary
    cd03593
    Location:102218
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    9986119..10001894 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520686.3XP_011518988.1  C-type lectin domain family 1 member B isoform X3

    Conserved Domains (1) summary
    cd03593
    Location:102187
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
  2. XM_011520685.2XP_011518987.1  C-type lectin domain family 1 member B isoform X2

    See identical proteins and their annotated locations for XP_011518987.1

    UniProtKB/Swiss-Prot
    Q9P126
    Related
    ENSP00000406338.2, ENST00000428126.6
    Conserved Domains (1) summary
    cd03593
    Location:69185
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
  3. XM_005253382.4XP_005253439.1  C-type lectin domain family 1 member B isoform X1

    See identical proteins and their annotated locations for XP_005253439.1

    UniProtKB/Swiss-Prot
    Q9P126
    Conserved Domains (1) summary
    cd03593
    Location:102218
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
  4. XM_017019395.1XP_016874884.1  C-type lectin domain family 1 member B isoform X1

    UniProtKB/Swiss-Prot
    Q9P126
    Conserved Domains (1) summary
    cd03593
    Location:102218
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
  5. XM_017019396.1XP_016874885.1  C-type lectin domain family 1 member B isoform X4

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