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CDKL3 cyclin dependent kinase like 3 [ Homo sapiens (human) ]

Gene ID: 51265, updated on 12-Oct-2019

Summary

Official Symbol
CDKL3provided by HGNC
Official Full Name
cyclin dependent kinase like 3provided by HGNC
Primary source
HGNC:HGNC:15483
See related
Ensembl:ENSG00000006837 MIM:608459
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NKIAMRE
Summary
The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 4.9), brain (RPKM 1.0) and 12 other tissues See more
Orthologs

Genomic context

See CDKL3 in Genome Data Viewer
Location:
5q31.1
Exon count:
23
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (134236120..134372380, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (133571817..133706805, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene S-phase kinase associated protein 1 Neighboring gene protein phosphatase 2 catalytic subunit alpha Neighboring gene microRNA 3661 Neighboring gene ribosomal protein S13 pseudogene 6 Neighboring gene ubiquitin conjugating enzyme E2 B Neighboring gene CDKN2A interacting protein N-terminal like Neighboring gene ribosomal protein S10 pseudogene 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cellular protein modification process TAS
Traceable Author Statement
more info
PubMed 
dendrite extension IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of axon extension IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of dendrite morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cyclin-dependent kinase-like 3
Names
serine-threonine protein kinase NKIAMRE
NP_001107047.1
NP_001287782.1
NP_001336292.1
NP_001336293.1
NP_001336294.1
NP_001336295.1
NP_057592.2
XP_011541731.1
XP_016865021.1
XP_016865022.1
XP_016865023.1
XP_016865025.1
XP_016865033.1
XP_016865034.1
XP_016865035.1
XP_016865036.1
XP_024301854.1
XP_024301855.1
XP_024301856.1
XP_024301857.1
XP_024301858.1
XP_024301859.1
XP_024301860.1
XP_024301861.1
XP_024301862.1
XP_024301863.1
XP_024301864.1
XP_024301865.1
XP_024301866.1
XP_024301867.1
XP_024301868.1
XP_024301869.1
XP_024301870.1
XP_024301871.1
XP_024301872.1
XP_024301873.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042179.2 RefSeqGene

    Range
    5001..77624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001113575.2NP_001107047.1  cyclin-dependent kinase-like 3 isoform 1

    See identical proteins and their annotated locations for NP_001107047.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC109454, BC041799, BX104333
    Consensus CDS
    CCDS47264.1
    UniProtKB/Swiss-Prot
    Q8IVW4
    Related
    ENSP00000265334.4, ENST00000265334.9
    Conserved Domains (1) summary
    cd07846
    Location:2286
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
  2. NM_001300853.1NP_001287782.1  cyclin-dependent kinase-like 3 isoform 3

    See identical proteins and their annotated locations for NP_001287782.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate 5' exon, which results in a different 5' UTR and translation initiation at a downstream start codon, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK301802, AK310955, BC041799, BX104333
    Consensus CDS
    CCDS75303.1
    UniProtKB/Swiss-Prot
    Q8IVW4
    UniProtKB/TrEMBL
    B4DX41
    Related
    ENSP00000428500.1, ENST00000523054.5
    Conserved Domains (1) summary
    cl21453
    Location:197
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001349363.1NP_001336292.1  cyclin-dependent kinase-like 3 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream start codon, and includes an alternate penultimate exon, compared to variant 1, resulting in a novel 3' coding region and longer 3' UTR, compared to variant 1. The resulting isoform (4) has a shorter N-terminus and a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK301802, AK310955, BC041799, BX104333, CR740901
    Conserved Domains (1) summary
    cl21453
    Location:197
    PKc_like; Protein Kinases, catalytic domain
  4. NM_001349364.1NP_001336293.1  cyclin-dependent kinase-like 3 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream start codon, and includes an alternate penultimate exon, compared to variant 1, resulting in a novel 3' coding region and longer 3' UTR, compared to variant 1. The resulting isoform (5) has a shorter N-terminus and a distinct C-terminus compared to isoform 1. Variants 5, 6, and 7 encode the same isoform (5).
    Source sequence(s)
    AK294740, AK310955, BX104333, CR740901
  5. NM_001349365.1NP_001336294.1  cyclin-dependent kinase-like 3 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream start codon, and includes an alternate penultimate exon, compared to variant 1, resulting in a novel 3' coding region and longer 3' UTR, compared to variant 1. The resulting isoform (5) has a shorter N-terminus and a distinct C-terminus compared to isoform 1. Variants 5, 6, and 7 encode the same isoform (5).
    Source sequence(s)
    AK294740, AK310955, BX104333, CR740901, DC372363
  6. NM_001349366.1NP_001336295.1  cyclin-dependent kinase-like 3 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream start codon, and includes an alternate penultimate exon, compared to variant 1, resulting in a novel 3' coding region and longer 3' UTR, compared to variant 1. The resulting isoform (5) has a shorter N-terminus and a distinct C-terminus compared to isoform 1. Variants 5, 6, and 7 encode the same isoform (5).
    Source sequence(s)
    AK294740, AK310955, BX104333, CR740901, DC353401
  7. NM_016508.3NP_057592.2  cyclin-dependent kinase-like 3 isoform 2

    See identical proteins and their annotated locations for NP_057592.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AF130372, BC041799
    Consensus CDS
    CCDS47265.1
    UniProtKB/Swiss-Prot
    Q8IVW4
    Related
    ENSP00000430496.1, ENST00000523832.1
    Conserved Domains (2) summary
    smart00220
    Location:4286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07846
    Location:2286
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    134236120..134372380 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446092.1XP_024301860.1  cyclin-dependent kinase-like 3 isoform X6

    Conserved Domains (1) summary
    cl21453
    Location:2298
    PKc_like; Protein Kinases, catalytic domain
  2. XM_024446091.1XP_024301859.1  cyclin-dependent kinase-like 3 isoform X5

    Conserved Domains (1) summary
    cl21453
    Location:2298
    PKc_like; Protein Kinases, catalytic domain
  3. XM_024446093.1XP_024301861.1  cyclin-dependent kinase-like 3 isoform X8

    Conserved Domains (1) summary
    cl21453
    Location:77182
    PKc_like; Protein Kinases, catalytic domain
  4. XM_024446099.1XP_024301867.1  cyclin-dependent kinase-like 3 isoform X11

    Conserved Domains (1) summary
    cl21453
    Location:197
    PKc_like; Protein Kinases, catalytic domain
  5. XM_024446101.1XP_024301869.1  cyclin-dependent kinase-like 3 isoform X11

    Conserved Domains (1) summary
    cl21453
    Location:197
    PKc_like; Protein Kinases, catalytic domain
  6. XM_024446097.1XP_024301865.1  cyclin-dependent kinase-like 3 isoform X11

    Conserved Domains (1) summary
    cl21453
    Location:197
    PKc_like; Protein Kinases, catalytic domain
  7. XM_017009545.2XP_016865034.1  cyclin-dependent kinase-like 3 isoform X13

  8. XM_024446103.1XP_024301871.1  cyclin-dependent kinase-like 3 isoform X12

    Conserved Domains (1) summary
    cl21453
    Location:197
    PKc_like; Protein Kinases, catalytic domain
  9. XM_024446100.1XP_024301868.1  cyclin-dependent kinase-like 3 isoform X11

    Conserved Domains (1) summary
    cl21453
    Location:197
    PKc_like; Protein Kinases, catalytic domain
  10. XM_017009544.2XP_016865033.1  cyclin-dependent kinase-like 3 isoform X13

  11. XM_024446096.1XP_024301864.1  cyclin-dependent kinase-like 3 isoform X11

    Conserved Domains (1) summary
    cl21453
    Location:197
    PKc_like; Protein Kinases, catalytic domain
  12. XM_024446086.1XP_024301854.1  cyclin-dependent kinase-like 3 isoform X1

    Conserved Domains (1) summary
    cd07846
    Location:2298
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
  13. XM_024446104.1XP_024301872.1  cyclin-dependent kinase-like 3 isoform X11

    Conserved Domains (1) summary
    cl21453
    Location:197
    PKc_like; Protein Kinases, catalytic domain
  14. XM_024446095.1XP_024301863.1  cyclin-dependent kinase-like 3 isoform X10

    Conserved Domains (1) summary
    cl21453
    Location:2298
    PKc_like; Protein Kinases, catalytic domain
  15. XM_017009536.1XP_016865025.1  cyclin-dependent kinase-like 3 isoform X7

    Conserved Domains (2) summary
    smart00220
    Location:4243
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:2276
    PKc_like; Protein Kinases, catalytic domain
  16. XM_024446087.1XP_024301855.1  cyclin-dependent kinase-like 3 isoform X1

    Conserved Domains (1) summary
    cd07846
    Location:2298
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
  17. XM_011543429.2XP_011541731.1  cyclin-dependent kinase-like 3 isoform X1

    See identical proteins and their annotated locations for XP_011541731.1

    Conserved Domains (1) summary
    cd07846
    Location:2298
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
  18. XM_024446089.1XP_024301857.1  cyclin-dependent kinase-like 3 isoform X2

    Conserved Domains (1) summary
    cd07846
    Location:2286
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
  19. XM_024446088.1XP_024301856.1  cyclin-dependent kinase-like 3 isoform X2

    Conserved Domains (1) summary
    cd07846
    Location:2286
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
  20. XM_017009532.1XP_016865021.1  cyclin-dependent kinase-like 3 isoform X2

    Conserved Domains (1) summary
    cd07846
    Location:2286
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
  21. XM_017009533.1XP_016865022.1  cyclin-dependent kinase-like 3 isoform X3

    Conserved Domains (2) summary
    smart00220
    Location:4298
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:2298
    PKc_like; Protein Kinases, catalytic domain
  22. XM_024446098.1XP_024301866.1  cyclin-dependent kinase-like 3 isoform X11

    Conserved Domains (1) summary
    cl21453
    Location:197
    PKc_like; Protein Kinases, catalytic domain
  23. XM_017009546.1XP_016865035.1  cyclin-dependent kinase-like 3 isoform X13

  24. XM_024446094.1XP_024301862.1  cyclin-dependent kinase-like 3 isoform X9

    Conserved Domains (1) summary
    cl21453
    Location:28145
    PKc_like; Protein Kinases, catalytic domain
  25. XM_017009547.1XP_016865036.1  cyclin-dependent kinase-like 3 isoform X13

  26. XM_024446102.1XP_024301870.1  cyclin-dependent kinase-like 3 isoform X11

    Conserved Domains (1) summary
    cl21453
    Location:197
    PKc_like; Protein Kinases, catalytic domain
  27. XM_024446105.1XP_024301873.1  cyclin-dependent kinase-like 3 isoform X13

  28. XM_017009534.1XP_016865023.1  cyclin-dependent kinase-like 3 isoform X4

    Conserved Domains (1) summary
    cd07846
    Location:2298
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
  29. XM_024446090.1XP_024301858.1  cyclin-dependent kinase-like 3 isoform X4

    Related
    ENSP00000428689.1, ENST00000521118.5
    Conserved Domains (1) summary
    cd07846
    Location:2298
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3

RNA

  1. XR_002956159.1 RNA Sequence

  2. XR_002956160.1 RNA Sequence

  3. XR_002956161.1 RNA Sequence

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