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MRPL27 mitochondrial ribosomal protein L27 [ Homo sapiens (human) ]

Gene ID: 51264, updated on 3-May-2020

Summary

Official Symbol
MRPL27provided by HGNC
Official Full Name
mitochondrial ribosomal protein L27provided by HGNC
Primary source
HGNC:HGNC:14483
See related
Ensembl:ENSG00000108826 MIM:611837
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L27mt
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in colon (RPKM 30.2), kidney (RPKM 28.1) and 25 other tissues See more
Orthologs

Genomic context

See MRPL27 in Genome Data Viewer
Location:
17q21.33
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (50367867..50373184, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (48445228..48450562, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene TMEM92 antisense RNA 1 Neighboring gene xylosyltransferase 2 Neighboring gene essential meiotic structure-specific endonuclease 1 Neighboring gene leucine rich repeat containing 59 Neighboring gene acyl-CoA synthetase family member 2 Neighboring gene mitochondrial ribosomal protein S21 pseudogene 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC23716

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
translation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial large ribosomal subunit NAS
Non-traceable Author Statement
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
39S ribosomal protein L27, mitochondrial
Names
MRP-L27
mitochondrial large ribosomal subunit protein bL27m

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016504.3NP_057588.1  39S ribosomal protein L27, mitochondrial

    See identical proteins and their annotated locations for NP_057588.1

    Status: REVIEWED

    Source sequence(s)
    AF151084
    Consensus CDS
    CCDS11564.1
    UniProtKB/Swiss-Prot
    Q9P0M9
    Related
    ENSP00000225969.4, ENST00000225969.9
    Conserved Domains (1) summary
    pfam01016
    Location:31101
    Ribosomal_L27; Ribosomal L27 protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    50367867..50373184 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_148570.1: Suppressed sequence

    Description
    NM_148570.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_148571.1: Suppressed sequence

    Description
    NM_148571.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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