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FGD2 FYVE, RhoGEF and PH domain containing 2 [ Bos taurus (cattle) ]

Gene ID: 512593, updated on 5-Mar-2024

Summary

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Official Symbol
FGD2provided by VGNC
Official Full Name
FYVE, RhoGEF and PH domain containing 2provided by VGNC
Primary source
VGNC:VGNC:28965
See related
BGD:BT12918; Ensembl:ENSBTAG00000014172
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 23
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 23 NC_037350.1 (10916251..10942801)

Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene peptidase inhibitor 16 Neighboring gene mitochondrial carrier 1 Neighboring gene uncharacterized LOC132343602 Neighboring gene uncharacterized LOC101907794

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
  2. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in filopodium assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
FYVE, RhoGEF and PH domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001075570.1 → NP_001069038.1  FYVE, RhoGEF and PH domain-containing protein 2

    See identical proteins and their annotated locations for NP_001069038.1

    Status: PROVISIONAL

    Source sequence(s)
    BT026545
    UniProtKB/TrEMBL
    Q0V7M5
    Related
    ENSBTAP00000018834.4, ENSBTAT00000018834.6
    Conserved Domains (5) summary
    cd00160
    Location:105 → 289
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13236
    Location:539 → 641
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd13386
    Location:321 → 428
    PH1_FGD2; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 2, N-terminal Pleckstrin homology (PH) domain
    cd15741
    Location:454 → 518
    FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
    pfam00169
    Location:321 → 418
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    10916251..10942801
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005223324.5 → XP_005223381.1  FYVE, RhoGEF and PH domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A3Q1MJL7
    Related
    ENSBTAP00000071557.1, ENSBTAT00000081202.2
    Conserved Domains (5) summary
    cd00160
    Location:105 → 289
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13236
    Location:508 → 610
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd15741
    Location:423 → 487
    FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
    pfam00169
    Location:517 → 611
    PH; PH domain
    cl17171
    Location:321 → 397
    PH-like; Pleckstrin homology-like domain

  2. XM_005223323.5 → XP_005223380.1  FYVE, RhoGEF and PH domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005223380.1

    UniProtKB/TrEMBL
    F1MM93
    Conserved Domains (5) summary
    cd00160
    Location:105 → 289
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13236
    Location:539 → 641
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd13386
    Location:321 → 428
    PH1_FGD2; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 2, N-terminal Pleckstrin homology (PH) domain
    cd15741
    Location:454 → 518
    FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
    pfam00169
    Location:321 → 418
    PH; PH domain

  3. XM_015459765.3 → XP_015315251.1  FYVE, RhoGEF and PH domain-containing protein 2 isoform X3

    Conserved Domains (5) summary
    cd13236
    Location:344 → 446
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd13386
    Location:126 → 233
    PH1_FGD2; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 2, N-terminal Pleckstrin homology (PH) domain
    cd15741
    Location:259 → 323
    FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
    pfam00169
    Location:126 → 223
    PH; PH domain
    pfam00621
    Location:1 → 95
    RhoGEF; RhoGEF domain

  4. XM_015459767.3 → XP_015315253.1  FYVE, RhoGEF and PH domain-containing protein 2 isoform X4

    Conserved Domains (5) summary
    cd13236
    Location:338 → 440
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd13386
    Location:120 → 227
    PH1_FGD2; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 2, N-terminal Pleckstrin homology (PH) domain
    cd15741
    Location:253 → 317
    FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
    pfam00169
    Location:120 → 217
    PH; PH domain
    cl02571
    Location:36 → 88
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

  5. XM_059880298.1 → XP_059736281.1  FYVE, RhoGEF and PH domain-containing protein 2 isoform X4

Nucleotide Protein Strain
Heading Accession and Version

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