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FAM178B family with sequence similarity 178 member B [ Homo sapiens (human) ]

Gene ID: 51252, updated on 19-Sep-2020

Summary

Official Symbol
FAM178Bprovided by HGNC
Official Full Name
family with sequence similarity 178 member Bprovided by HGNC
Primary source
HGNC:HGNC:28036
See related
Ensembl:ENSG00000168754
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in bone marrow (RPKM 5.6), testis (RPKM 2.5) and 3 other tissues See more
Orthologs

Genomic context

See FAM178B in Genome Data Viewer
Location:
2q11.2
Exon count:
24
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (96875882..96986600, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (97541619..97652337, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 39 Neighboring gene semaphorin 4C Neighboring gene uncharacterized LOC101927053 Neighboring gene RNA, 5S ribosomal pseudogene 101 Neighboring gene ribosomal L24 domain containing 1 pseudogene Neighboring gene cAMP responsive element binding protein 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of family with sequence similarity 178, member B (FAM178B) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122646.3NP_001116118.2  protein FAM178B isoform A

    Status: VALIDATED

    Description
    Transcript Variant: This variant (A) represents the longest transcript and encodes the longest isoform (A).
    Source sequence(s)
    AC079395, AK122705, BC039488, BI826484
    Consensus CDS
    CCDS46366.2
    UniProtKB/Swiss-Prot
    Q8IXR5
    UniProtKB/TrEMBL
    B3KV66
    Related
    ENSP00000429896.1, ENST00000490605.3
    Conserved Domains (2) summary
    PHA03321
    Location:51194
    PHA03321; tegument protein VP11/12; Provisional
    pfam14816
    Location:189541
    FAM178; Family of unknown function, FAM178
  2. NM_001172667.2NP_001166138.1  protein FAM178B isoform C precursor

    See identical proteins and their annotated locations for NP_001166138.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (C) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant A. The encoded isoform (C) has a distinct N-terminus and is shorter than isoform A.
    Source sequence(s)
    AC092636, BC038583, BX103404
    UniProtKB/Swiss-Prot
    Q8IXR5
    Related
    ENST00000470789.5
  3. NM_016490.5NP_057574.2  protein FAM178B isoform B

    See identical proteins and their annotated locations for NP_057574.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (B) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant A. The encoded isoform (B) is shorter than isoform A.
    Source sequence(s)
    BC038583, BC051379
    Consensus CDS
    CCDS33252.1
    UniProtKB/Swiss-Prot
    Q8IXR5
    Related
    ENSP00000377160.2, ENST00000393526.6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    96875882..96986600 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511294.2XP_011509596.1  protein FAM178B isoform X3

    Conserved Domains (1) summary
    pfam14816
    Location:193502
    FAM178; Family of unknown function, FAM178
  2. XM_017004264.1XP_016859753.1  protein FAM178B isoform X2

  3. XM_017004263.1XP_016859752.1  protein FAM178B isoform X1

  4. XM_024452951.1XP_024308719.1  protein FAM178B isoform X7

  5. XM_024452949.1XP_024308717.1  protein FAM178B isoform X6

    Conserved Domains (1) summary
    pfam14816
    Location:194
    FAM178; Family of unknown function, FAM178
  6. XM_024452950.1XP_024308718.1  protein FAM178B isoform X6

    Conserved Domains (1) summary
    pfam14816
    Location:194
    FAM178; Family of unknown function, FAM178
  7. XM_017004268.2XP_016859757.1  protein FAM178B isoform X9

    UniProtKB/Swiss-Prot
    Q8IXR5
  8. XM_017004267.2XP_016859756.1  protein FAM178B isoform X8

  9. XM_017004265.1XP_016859754.1  protein FAM178B isoform X4

  10. XM_011511297.3XP_011509599.1  protein FAM178B isoform X5

    Conserved Domains (1) summary
    pfam14816
    Location:193361
    FAM178; Family of unknown function, FAM178

RNA

  1. XR_001738764.1 RNA Sequence

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