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PDZD11 PDZ domain containing 11 [ Homo sapiens (human) ]

Gene ID: 51248, updated on 8-Jul-2021

Summary

Official Symbol
PDZD11provided by HGNC
Official Full Name
PDZ domain containing 11provided by HGNC
Primary source
HGNC:HGNC:28034
See related
Ensembl:ENSG00000120509 MIM:300632
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PISP; AIPP1; PDZK11
Expression
Ubiquitous expression in brain (RPKM 12.6), thyroid (RPKM 10.9) and 25 other tissues See more
Orthologs
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Genomic context

See PDZD11 in Genome Data Viewer
Location:
Xq13.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (70286595..70289958, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (69506445..69509777, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene pyrimidinergic receptor P2Y4 Neighboring gene arrestin 3 Neighboring gene RAB41, member RAS oncogene family Neighboring gene kinesin family member 4A Neighboring gene TRAPPC2L pseudogene 1 Neighboring gene RNY4 pseudogene 23

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in maintenance of epithelial cell apical/basal polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neurotransmitter secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in pore complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
 
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
part_of pore complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
PDZ domain-containing protein 11
Names
ATPase-interacting PDZ protein
PMCA-interacting single-PDZ protein
plasma membrane calcium ATPase-interacting single-PDZ protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370174.1NP_001357103.1  PDZ domain-containing protein 11 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL357752
    Related
    ENSP00000363578.1, ENST00000374454.1
    Conserved Domains (1) summary
    cd00992
    Location:45125
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  2. NM_001370175.1NP_001357104.1  PDZ domain-containing protein 11 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL357752
    Conserved Domains (1) summary
    cd00992
    Location:45125
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  3. NM_001370176.1NP_001357105.1  PDZ domain-containing protein 11 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL357752
    Conserved Domains (1) summary
    cd00992
    Location:45125
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  4. NM_001370177.1NP_001357106.1  PDZ domain-containing protein 11 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL357752
    Conserved Domains (1) summary
    cd00992
    Location:45125
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  5. NM_001370178.1NP_001357107.1  PDZ domain-containing protein 11 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL357752
    Conserved Domains (1) summary
    cd00992
    Location:45106
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  6. NM_016484.5NP_057568.1  PDZ domain-containing protein 11 isoform 1

    See identical proteins and their annotated locations for NP_057568.1

    Status: VALIDATED

    Source sequence(s)
    AL357752
    Consensus CDS
    CCDS14400.1
    UniProtKB/Swiss-Prot
    Q5EBL8
    Related
    ENSP00000239666.4, ENST00000239666.9
    Conserved Domains (1) summary
    cd00992
    Location:45125
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    70286595..70289958 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029568.2XP_016885057.1  PDZ domain-containing protein 11 isoform X1

    UniProtKB/Swiss-Prot
    Q5EBL8
    Conserved Domains (1) summary
    cd00992
    Location:77157
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
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