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PAIP2 poly(A) binding protein interacting protein 2 [ Homo sapiens (human) ]

Gene ID: 51247, updated on 3-Apr-2024

Summary

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Official Symbol
PAIP2provided by HGNC
Official Full Name
poly(A) binding protein interacting protein 2provided by HGNC
Primary source
HGNC:HGNC:17970
See related
Ensembl:ENSG00000120727 MIM:605604; AllianceGenome:HGNC:17970
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAIP-2; PAIP2A
Summary
Enables translation repressor activity. Involved in negative regulation of translational initiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 45.2), adrenal (RPKM 41.5) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
5q31.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (139341854..139369717)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (139867910..139895795)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (138677543..138705406)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene matrin 3 Neighboring gene Sharpr-MPRA regulatory region 13556 Neighboring gene RNA, 5S ribosomal pseudogene 195 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:138657767-138658966 Neighboring gene RN7SK pseudogene 64 Neighboring gene solute carrier family 23 member 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:138716531-138717471 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23219 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16408 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23220 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23221 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23223 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:138723739-138724286 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:138724287-138724834 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:138724835-138725382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23225 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16409 Neighboring gene Sharpr-MPRA regulatory region 996 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16410 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23227 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23228 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16411 Neighboring gene spermatogenesis associated 24 Neighboring gene marginal zone B and B1 cell specific protein Neighboring gene proline rich basic protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Structure and function of the C-terminal PABC domain of human poly(A)-binding protein. Kozlov G, et al. Proc Natl Acad Sci U S A, 2001 Apr 10. PMID 11287632, Free PMC Article
  2. Polyadenylate-binding protein-interacting proteins PAIP1 and PAIP2 affect translation termination. Ivanov A, et al. J Biol Chem, 2019 May 24. PMID 30992367, Free PMC Article
  3. A new role for the cellular PABP repressor Paip2 as an innate restriction factor capable of limiting productive cytomegalovirus replication. McKinney C, et al. Genes Dev, 2013 Aug 15. PMID 23964095, Free PMC Article
  4. Fructose modulates GLUT5 mRNA stability in differentiated Caco-2 cells: role of cAMP-signalling pathway and PABP (polyadenylated-binding protein)-interacting protein (Paip) 2. Gouyon F, et al. Biochem J, 2003 Oct 1. PMID 12820898, Free PMC Article
  5. Dual interactions of the translational repressor Paip2 with poly(A) binding protein. Khaleghpour K, et al. Mol Cell Biol, 2001 Aug. PMID 11438674, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results indicated that PAIP1 and PAIP2 participate in translation termination and are important regulators of readthrough at the premature termination codon.
    Title: Polyadenylate-binding protein-interacting proteins PAIP1 and PAIP2 affect translation termination.
  2. Paip2 is a host antiviral restriction factor antagonized by PABP accumulation in HCMV-infected cells
    Title: A new role for the cellular PABP repressor Paip2 as an innate restriction factor capable of limiting productive cytomegalovirus replication.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis.
  4. Role of PAIP2 in modulation of GLUT5 mRNA stability.
    Title: Fructose modulates GLUT5 mRNA stability in differentiated Caco-2 cells: role of cAMP-signalling pathway and PABP (polyadenylated-binding protein)-interacting protein (Paip) 2.
  5. PAIP2 is a crucial regulator of VEGF mRNA and has a role in regulating angiogenesis
    Title: Poly(A)-binding protein-interacting protein 2, a strong regulator of vascular endothelial growth factor mRNA.
  6. The turnover of Paip2 in the cell is mediated by EDD and is regulated by PABP.
    Title: Poly(A) binding protein (PABP) homeostasis is mediated by the stability of its inhibitor, Paip2.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC72018

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA regulatory element binding translation repressor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables translation repressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation repressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in memory IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of translational initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
polyadenylate-binding protein-interacting protein 2
Names
PABC1-interacting protein 2
PABP-interacting protein 2
polyA-binding protein-interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033112.3 → NP_001028284.1  polyadenylate-binding protein-interacting protein 2

    See identical proteins and their annotated locations for NP_001028284.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC039337, BC062718, BU732743
    Consensus CDS
    CCDS4211.1
    UniProtKB/Swiss-Prot
    B2RBI1, D3DQC6, Q49A06, Q9BPZ3, Q9H0Y5, Q9P0Q8
    UniProtKB/TrEMBL
    Q49AE6, Q6FID7
    Related
    ENSP00000422508.1, ENST00000510080.1
    Conserved Domains (1) summary
    pfam07145
    Location:108 → 123
    PAM2; Ataxin-2 C-terminal region

  2. NM_016480.5 → NP_057564.3  polyadenylate-binding protein-interacting protein 2

    See identical proteins and their annotated locations for NP_057564.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC039337, BI552800, BU732743
    Consensus CDS
    CCDS4211.1
    UniProtKB/Swiss-Prot
    B2RBI1, D3DQC6, Q49A06, Q9BPZ3, Q9H0Y5, Q9P0Q8
    UniProtKB/TrEMBL
    Q49AE6, Q6FID7
    Related
    ENSP00000265192.4, ENST00000265192.9
    Conserved Domains (1) summary
    pfam07145
    Location:108 → 123
    PAM2; Ataxin-2 C-terminal region

RNA

  1. NR_109830.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    BC039337, BI552800, BU732743

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    139341854..139369717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009522.2 → XP_016865011.1  polyadenylate-binding protein-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RBI1, D3DQC6, Q49A06, Q9BPZ3, Q9H0Y5, Q9P0Q8
    UniProtKB/TrEMBL
    Q49AE6, Q6FID7
    Related
    ENSP00000378275.2, ENST00000394795.6
    Conserved Domains (1) summary
    pfam07145
    Location:108 → 123
    PAM2; Ataxin-2 C-terminal region

  2. XM_011543428.2 → XP_011541730.1  polyadenylate-binding protein-interacting protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011541730.1

    UniProtKB/Swiss-Prot
    B2RBI1, D3DQC6, Q49A06, Q9BPZ3, Q9H0Y5, Q9P0Q8
    UniProtKB/TrEMBL
    Q49AE6, Q6FID7
    Conserved Domains (1) summary
    pfam07145
    Location:108 → 123
    PAM2; Ataxin-2 C-terminal region

  3. XM_047417265.1 → XP_047273221.1  polyadenylate-binding protein-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RBI1, D3DQC6, Q49A06, Q9BPZ3, Q9H0Y5, Q9P0Q8

  4. XM_047417266.1 → XP_047273222.1  polyadenylate-binding protein-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RBI1, D3DQC6, Q49A06, Q9BPZ3, Q9H0Y5, Q9P0Q8

  5. XM_017009523.3 → XP_016865012.1  polyadenylate-binding protein-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RBI1, D3DQC6, Q49A06, Q9BPZ3, Q9H0Y5, Q9P0Q8
    UniProtKB/TrEMBL
    Q49AE6, Q6FID7
    Conserved Domains (1) summary
    pfam07145
    Location:108 → 123
    PAM2; Ataxin-2 C-terminal region

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    139867910..139895795
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352722.1 → XP_054208697.1  polyadenylate-binding protein-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RBI1, D3DQC6, Q49A06, Q9BPZ3, Q9H0Y5, Q9P0Q8

  2. XM_054352723.1 → XP_054208698.1  polyadenylate-binding protein-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RBI1, D3DQC6, Q49A06, Q9BPZ3, Q9H0Y5, Q9P0Q8

  3. XM_054352724.1 → XP_054208699.1  polyadenylate-binding protein-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RBI1, D3DQC6, Q49A06, Q9BPZ3, Q9H0Y5, Q9P0Q8

  4. XM_054352725.1 → XP_054208700.1  polyadenylate-binding protein-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RBI1, D3DQC6, Q49A06, Q9BPZ3, Q9H0Y5, Q9P0Q8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BPZ3.1 GenPept UniProtKB/Swiss-Prot:Q9BPZ3

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