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PAIP2 poly(A) binding protein interacting protein 2 [ Homo sapiens (human) ]

Gene ID: 51247, updated on 5-Aug-2022

Summary

Official Symbol
PAIP2provided by HGNC
Official Full Name
poly(A) binding protein interacting protein 2provided by HGNC
Primary source
HGNC:HGNC:17970
See related
Ensembl:ENSG00000120727 MIM:605604; AllianceGenome:HGNC:17970
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAIP-2; PAIP2A
Summary
Enables translation repressor activity. Involved in negative regulation of translational initiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 45.2), adrenal (RPKM 41.5) and 25 other tissues See more
Orthologs
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Genomic context

See PAIP2 in Genome Data Viewer
Location:
5q31.2
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (139341854..139369717)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (139867916..139895795)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (138677543..138705406)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene matrin 3 Neighboring gene Sharpr-MPRA regulatory region 13556 Neighboring gene RN7SK pseudogene 64 Neighboring gene solute carrier family 23 member 1 Neighboring gene Sharpr-MPRA regulatory region 996 Neighboring gene marginal zone B and B1 cell specific protein Neighboring gene proline rich basic protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC72018

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mRNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA regulatory element binding translation repressor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables translation repressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables translation repressor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in memory IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
polyadenylate-binding protein-interacting protein 2
Names
PABC1-interacting protein 2
PABP-interacting protein 2
polyA-binding protein-interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033112.3NP_001028284.1  polyadenylate-binding protein-interacting protein 2

    See identical proteins and their annotated locations for NP_001028284.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC039337, BC062718, BU732743
    Consensus CDS
    CCDS4211.1
    UniProtKB/Swiss-Prot
    Q9BPZ3, Q9P0Q8
    UniProtKB/TrEMBL
    Q49AE6
    Related
    ENSP00000422508.1, ENST00000510080.1
    Conserved Domains (1) summary
    pfam07145
    Location:108123
    PAM2; Ataxin-2 C-terminal region
  2. NM_016480.5NP_057564.3  polyadenylate-binding protein-interacting protein 2

    See identical proteins and their annotated locations for NP_057564.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC039337, BI552800, BU732743
    Consensus CDS
    CCDS4211.1
    UniProtKB/Swiss-Prot
    Q9BPZ3, Q9P0Q8
    UniProtKB/TrEMBL
    Q49AE6
    Related
    ENSP00000265192.4, ENST00000265192.9
    Conserved Domains (1) summary
    pfam07145
    Location:108123
    PAM2; Ataxin-2 C-terminal region

RNA

  1. NR_109830.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    BC039337, BI552800, BU732743

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    139341854..139369717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009522.2XP_016865011.1  polyadenylate-binding protein-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9BPZ3, Q9P0Q8
    Related
    ENSP00000378275.2, ENST00000394795.6
    Conserved Domains (1) summary
    pfam07145
    Location:108123
    PAM2; Ataxin-2 C-terminal region
  2. XM_011543428.2XP_011541730.1  polyadenylate-binding protein-interacting protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011541730.1

    UniProtKB/Swiss-Prot
    Q9BPZ3, Q9P0Q8
    Conserved Domains (1) summary
    pfam07145
    Location:108123
    PAM2; Ataxin-2 C-terminal region
  3. XM_047417265.1XP_047273221.1  polyadenylate-binding protein-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9P0Q8
  4. XM_047417266.1XP_047273222.1  polyadenylate-binding protein-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9P0Q8
  5. XM_017009523.3XP_016865012.1  polyadenylate-binding protein-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9BPZ3, Q9P0Q8
    Conserved Domains (1) summary
    pfam07145
    Location:108123
    PAM2; Ataxin-2 C-terminal region

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    139867916..139895795
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)