HBA hemoglobin, alpha 2 [Bos taurus (domestic cattle)] - Gene

Summary

Gene symbol: HBA
Gene description: hemoglobin, alpha 2
See related: BGD:BT22091
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: HBA2; alpha globin
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Genomic context

Location:: chromosome: 25

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	25	NC_037352.1 (216496..217264)

Chromosome 25 - NC_037352.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037352.1 Chromosome 25 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A broad spectrum of alpha-thalassemia alleles has been detected among Iranians and -alpha3.7 kb was the most prevalent Thalassemia mutation.
Title: Prevalence and Genetic Analysis of α- and β-Thalassemia and Sickle Cell Anemia in Southwest Iran.
both Ciprofloxacin and enrofloxacin could lead to the conformational and microenvironmental changes of bovine hemoglobin.
Title: Experimental and computational characterization on the binding of two fluoroquinolones to bovine hemoglobin.
Determination of a representative formal redox potentials of the Fe(II)/Fe(III) redox couple cyanhaemoglobin/cyanmethaemoglobin and the myoglobin/metmyoglobin , at pH=7 and related to the state in solution, was the objective of this work.
Title: Determination of the formal redox potentials of the cyanhaemoglobin/cyanmethaemoglobin and the myoglobin/metmyoglobin couples at neutral pH.
Data indicate that on incubating hemoglobin with glyoxal for 0-20 days, advanced glycation end products (AGEs) were detected on day 20.
Title: Molten globule of hemoglobin proceeds into aggregates and advanced glycated end products.
Ultraviolet irradiation results in fluorescence enhancement of bovine hemoblobin in a dose-dependent manner.
Title: Ultraviolet irradiation-dependent fluorescence enhancement of hemoglobin catalyzed by reactive oxygen species.
These results indicate that IsdX2 has all the features required to acquire heme from the host and transport heme to the bacterial cell wall.
Title: The five near-iron transporter (NEAT) domain anthrax hemophore, IsdX2, scavenges heme from hemoglobin and transfers heme to the surface protein IsdC.
The acid-induced denaturation of Hb follows a highly symmetric mechanism.
Title: Symmetric behavior of hemoglobin alpha- and beta- subunits during acid-induced denaturation observed by electrospray mass spectrometry.
Residues 33-61a of hemoglobin alpha-chain from cattle tick gut exhibit nonconventional conformation for an antimicrobial peptide, bound to sodium dodecyl sulfate micelles. The peptide is able to disrupt the bacterial membrane of Micrococcus luteus A270.
Title: The micelle-bound structure of an antimicrobial peptide derived from the alpha-chain of bovine hemoglobin isolated from the tick Boophilus microplus.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables haptoglobin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info	PubMed
enables iron ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables organic acid binding	IEA Inferred from Electronic Annotation more info	PubMed
enables oxygen binding	IEA Inferred from Electronic Annotation more info	PubMed
enables oxygen carrier activity	IEA Inferred from Electronic Annotation more info	PubMed
enables peroxidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in hydrogen peroxide catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in oxygen transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in blood microparticle	IEA Inferred from Electronic Annotation more info	PubMed
part_of haptoglobin-hemoglobin complex	IEA Inferred from Electronic Annotation more info	PubMed
part_of hemoglobin complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: hemoglobin subunit alpha

Names: alpha-globin; hemoglobin alpha chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.