Format

Send to:

Choose Destination

MZB1 marginal zone B and B1 cell specific protein [ Homo sapiens (human) ]

Gene ID: 51237, updated on 1-Aug-2020

Summary

Official Symbol
MZB1provided by HGNC
Official Full Name
marginal zone B and B1 cell specific proteinprovided by HGNC
Primary source
HGNC:HGNC:30125
See related
Ensembl:ENSG00000170476 MIM:609447
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PACAP; pERp1; MEDA-7
Expression
Biased expression in lymph node (RPKM 68.4), urinary bladder (RPKM 65.2) and 13 other tissues See more
Orthologs

Genomic context

See MZB1 in Genome Data Viewer
Location:
5q31.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (139387467..139389913, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (138723257..138725605, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 64 Neighboring gene poly(A) binding protein interacting protein 2 Neighboring gene solute carrier family 23 member 1 Neighboring gene proline rich basic protein 1 Neighboring gene spermatogenesis associated 24

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32987, MGC29506

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
integrin activation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of immunoglobulin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of immunoglobulin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of B cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of B cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
endoplasmic reticulum chaperone complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum chaperone complex ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum lumen ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
marginal zone B- and B1-cell-specific protein
Names
HSPC190
caspase-2 binding protein
mesenteric estrogen-dependent adipose 7
mesenteric oestrogen-dependent adipose gene- 7
plasma cell-induced ER protein 1
plasma cell-induced resident ER protein
plasma cell-induced resident endoplasmic reticulum protein
proapoptotic caspase adapter protein
proapoptotic caspase adaptor protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016459.4NP_057543.2  marginal zone B- and B1-cell-specific protein precursor

    See identical proteins and their annotated locations for NP_057543.2

    Status: VALIDATED

    Source sequence(s)
    AC135457, BC021275, BU601458
    Consensus CDS
    CCDS47273.1
    UniProtKB/Swiss-Prot
    Q8WU39
    Related
    ENSP00000303920.8, ENST00000302125.9
    Conserved Domains (1) summary
    pfam11938
    Location:49172
    DUF3456; TLR4 regulator and MIR-interacting MSAP

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    139387467..139389913 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center