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GLTP glycolipid transfer protein [ Homo sapiens (human) ]

Gene ID: 51228, updated on 7-Dec-2018

Summary

Official Symbol
GLTPprovided by HGNC
Official Full Name
glycolipid transfer proteinprovided by HGNC
Primary source
HGNC:HGNC:24867
See related
Ensembl:ENSG00000139433 MIM:608949
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is similar to bovine and porcine proteins which accelerate transfer of certain glycosphingolipids and glyceroglycolipids between membranes. It is thought to be a cytoplasmic protein. [provided by RefSeq, Jul 2008]
Expression
Broad expression in esophagus (RPKM 87.8), skin (RPKM 85.1) and 23 other tissues See more
Orthologs

Genomic context

See GLTP in Genome Data Viewer
Location:
12q24.11
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (109850943..109880488, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (110288748..110318293, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel subfamily V member 4 Neighboring gene uncharacterized LOC105369975 Neighboring gene microRNA 4497 Neighboring gene RNA, 7SL, cytoplasmic 441, pseudogene Neighboring gene trichoplein keratin filament binding Neighboring gene GIT ArfGAP 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of the metabolic syndrome in Indian Asian men.
NHGRI GWA Catalog

Pathways from BioSystems

  • Glycosphingolipid metabolism, organism-specific biosystem (from REACTOME)
    Glycosphingolipid metabolism, organism-specific biosystemThe steps involved in the synthesis of glycosphingolipids (sphingolipids with one or more sugars attached) are annotated here (Gault et al. 2010).
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Sphingolipid metabolism, organism-specific biosystem (from REACTOME)
    Sphingolipid metabolism, organism-specific biosystemSphingolipids are derivatives of long chain sphingoid bases such as sphingosine (trans-1,3-dihydroxy 2-amino-4-octadecene), an 18-carbon unsaturated amino alcohol which is the most abundant sphingoid...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ceramide 1-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ceramide 1-phosphate transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycolipid binding IDA
Inferred from Direct Assay
more info
PubMed 
glycolipid transporter activity TAS
Traceable Author Statement
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
intermembrane lipid transfer activity IDA
Inferred from Direct Assay
more info
PubMed 
lipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ceramide 1-phosphate transport IEA
Inferred from Electronic Annotation
more info
 
ceramide transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycolipid transport IEA
Inferred from Electronic Annotation
more info
 
glycosphingolipid metabolic process TAS
Traceable Author Statement
more info
 
intermembrane lipid transfer IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intermembrane lipid transfer IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
glycolipid transfer protein
Names
truncated glycolipid transfer protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016433.4NP_057517.1  glycolipid transfer protein

    See identical proteins and their annotated locations for NP_057517.1

    Status: REVIEWED

    Source sequence(s)
    AC007834, AF209704, AY372530, BC009932, BQ227117, CA310913
    Consensus CDS
    CCDS9136.1
    UniProtKB/Swiss-Prot
    Q9NZD2
    UniProtKB/TrEMBL
    A0A024RBI7
    Related
    ENSP00000315263.3, ENST00000318348.8
    Conserved Domains (1) summary
    pfam08718
    Location:22167
    GLTP; Glycolipid transfer protein (GLTP)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    109850943..109880488 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538434.3XP_011536736.1  glycolipid transfer protein isoform X1

    See identical proteins and their annotated locations for XP_011536736.1

    Conserved Domains (1) summary
    pfam08718
    Location:13126
    GLTP; Glycolipid transfer protein (GLTP)
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