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COPZ2 COPI coat complex subunit zeta 2 [ Homo sapiens (human) ]

Gene ID: 51226, updated on 1-Jun-2020

Summary

Official Symbol
COPZ2provided by HGNC
Official Full Name
COPI coat complex subunit zeta 2provided by HGNC
Primary source
HGNC:HGNC:19356
See related
Ensembl:ENSG00000005243 MIM:615526
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
zeta2-COP
Summary
This gene encodes a member of the adaptor complexes small subunit family. The encoded protein is a subunit of the coatomer protein complex, a seven-subunit complex that functions in the formation of COPI-type, non-clathrin-coated vesicles. COPI vesicles function in the retrograde Golgi-to-ER transport of dilysine-tagged proteins. [provided by RefSeq, Feb 2014]
Expression
Broad expression in fat (RPKM 13.1), prostate (RPKM 4.4) and 22 other tissues See more
Orthologs

Genomic context

See COPZ2 in Genome Data Viewer
Location:
17q21.32
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (48026167..48048086, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (46103533..46120908, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene proline rich 15 like Neighboring gene CDK5 regulatory subunit associated protein 3 Neighboring gene microRNA 10226 Neighboring gene microRNA 152 Neighboring gene nuclear factor, erythroid 2 like 1 Neighboring gene chromobox 1 Neighboring gene RNA, U6 small nuclear 1201, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC23008

Gene Ontology Provided by GOA

Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular protein transport NAS
Non-traceable Author Statement
more info
PubMed 
retrograde vesicle-mediated transport, Golgi to ER IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retrograde vesicle-mediated transport, Golgi to ER TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
COPI vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
COPI vesicle coat IDA
Inferred from Direct Assay
more info
PubMed 
COPI vesicle coat NAS
Non-traceable Author Statement
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
cis-Golgi network NAS
Non-traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum-Golgi intermediate compartment membrane IEA
Inferred from Electronic Annotation
more info
 
transport vesicle TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
coatomer subunit zeta-2
Names
coatomer protein complex subunit zeta 2
nonclathrin coat protein zeta-COP
zeta-2 COP
zeta-2-coat protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016429.4NP_057513.1  coatomer subunit zeta-2

    See identical proteins and their annotated locations for NP_057513.1

    Status: REVIEWED

    Source sequence(s)
    BC015924, BQ002984, HY179834
    Consensus CDS
    CCDS74092.1
    UniProtKB/Swiss-Prot
    Q9P299
    Related
    ENSP00000480707.1, ENST00000621465.5
    Conserved Domains (1) summary
    cl02092
    Location:45179
    Clat_adaptor_s; Clathrin adaptor complex small chain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    48026167..48048086 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524874.2XP_011523176.1  coatomer subunit zeta-2 isoform X1

    Conserved Domains (1) summary
    cl02092
    Location:45173
    Clat_adaptor_s; Clathrin adaptor complex small chain

RNA

  1. XR_002958017.1 RNA Sequence

  2. XR_934474.2 RNA Sequence

  3. XR_934471.3 RNA Sequence

  4. XR_934472.2 RNA Sequence

  5. XR_934473.2 RNA Sequence

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