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ELOA2 elongin A2 [ Homo sapiens (human) ]

Gene ID: 51224, updated on 1-Mar-2024

Summary

Official Symbol
ELOA2provided by HGNC
Official Full Name
elongin A2provided by HGNC
Primary source
HGNC:HGNC:30771
See related
Ensembl:ENSG00000206181 MIM:609522; AllianceGenome:HGNC:30771
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HsT832; TCEB3B; TCEB3L
Summary
This gene encodes the transcriptionally active subunit of the SIII (or elongin) transcription elongation factor complex, which also includes two regulatory subunits, elongins B and C. This complex acts to increase the rate of RNA chain elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites along the DNA template. Whereas a related protein with similar function, elongin A, is ubiquitously expressed, the encoded protein is specifically expressed in the testis, suggesting it may have a role in spermatogenesis. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See ELOA2 in Genome Data Viewer
Location:
18q21.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (47032527..47035621, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (47222798..47225892, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (44558898..44561992, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene katanin catalytic subunit A1 like 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:44546997-44547496 Neighboring gene elongin A3 family member D, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:44552405-44553168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:44553169-44553932 Neighboring gene MPRA-validated peak3137 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:44554945-44555448 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:44555449-44555951 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:44555952-44556454 Neighboring gene elongin A3 family member B, pseudogene Neighboring gene uncharacterized LOC105372098 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:44626710-44626922 Neighboring gene haloacid dehalogenase like hydrolase domain containing 2 Neighboring gene small ubiquitin-related modifier 2-like

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
elongin-A2
Names
RNA polymerase II transcription factor SIII subunit A2
transcription elongation factor (SIII) elongin A2 elongin A2
transcription elongation factor B polypeptide 3B
transcription elongation factor B subunit 3B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050760.1 RefSeqGene

    Range
    4997..8091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_016427.3NP_057511.2  elongin-A2

    See identical proteins and their annotated locations for NP_057511.2

    Status: REVIEWED

    Source sequence(s)
    AB030834, AC012254, BC036022
    Consensus CDS
    CCDS11932.1
    UniProtKB/Swiss-Prot
    Q8IYF1, Q9P2V9
    UniProtKB/TrEMBL
    B2RC86
    Related
    ENSP00000331302.4, ENST00000332567.6
    Conserved Domains (2) summary
    smart00509
    Location:877
    TFS2N; Domain in the N-terminus of transcription elongation factor S-II (and elsewhere)
    pfam06881
    Location:544642
    Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    47032527..47035621 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    47222798..47225892 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)