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ZNF219 zinc finger protein 219 [ Homo sapiens (human) ]

Gene ID: 51222, updated on 10-Oct-2019

Summary

Official Symbol
ZNF219provided by HGNC
Official Full Name
zinc finger protein 219provided by HGNC
Primary source
HGNC:HGNC:13011
See related
Ensembl:ENSG00000165804 MIM:605036
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFP219
Summary
This gene is a member of the Kruppel-like zinc finger gene family. The encoded protein functions as a transcriptional repressor of the high mobility group nucleosome binding domain 1 protein, which is associated with transcriptionally active chromatin. [provided by RefSeq, Apr 2017]
Expression
Ubiquitous expression in fat (RPKM 12.4), colon (RPKM 6.8) and 22 other tissues See more
Orthologs

Genomic context

See ZNF219 in Genome Data Viewer
Location:
14q11.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (21090046..21104721, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21558205..21572863, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene NDRG family member 2 Neighboring gene uncharacterized LOC105370398 Neighboring gene ribonuclease A family member 8 Neighboring gene Rho guanine nucleotide exchange factor 40 Neighboring gene transmembrane protein 253 Neighboring gene RNA, U6 small nuclear 252, pseudogene Neighboring gene cytoskeleton associated protein 2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Ectoderm Differentiation, organism-specific biosystem (from WikiPathways)
    Ectoderm Differentiation, organism-specific biosystemModel depicting ectoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lin...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
histamine receptor activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
limb bud formation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of chondrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of neurotransmitter levels IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053108.1 RefSeqGene

    Range
    5019..19677
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001101672.2NP_001095142.1  zinc finger protein 219

    See identical proteins and their annotated locations for NP_001095142.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK225811, BC000694
    Consensus CDS
    CCDS9568.1
    UniProtKB/Swiss-Prot
    Q9P2Y4
    Related
    ENSP00000392401.2, ENST00000421093.6
    Conserved Domains (4) summary
    sd00017
    Location:500520
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:500520
    zf-C2H2; Zinc finger, C2H2 type
    pfam04959
    Location:304408
    ARS2; Arsenite-resistance protein 2
    pfam13465
    Location:512534
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001102454.1NP_001095924.1  zinc finger protein 219

    See identical proteins and their annotated locations for NP_001095924.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK225811, BC000694, DA013397
    Consensus CDS
    CCDS9568.1
    UniProtKB/Swiss-Prot
    Q9P2Y4
    Related
    ENSP00000388558.2, ENST00000451119.6
    Conserved Domains (4) summary
    sd00017
    Location:500520
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:500520
    zf-C2H2; Zinc finger, C2H2 type
    pfam04959
    Location:304408
    ARS2; Arsenite-resistance protein 2
    pfam13465
    Location:512534
    zf-H2C2_2; Zinc-finger double domain
  3. NM_016423.3NP_057507.2  zinc finger protein 219

    See identical proteins and their annotated locations for NP_057507.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AB015427, AL161668, BC000694, CB152705
    Consensus CDS
    CCDS9568.1
    UniProtKB/Swiss-Prot
    Q9P2Y4
    Related
    ENSP00000354206.3, ENST00000360947.8
    Conserved Domains (4) summary
    sd00017
    Location:500520
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:500520
    zf-C2H2; Zinc finger, C2H2 type
    pfam04959
    Location:304408
    ARS2; Arsenite-resistance protein 2
    pfam13465
    Location:512534
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    21090046..21104721 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449623.1XP_024305391.1  zinc finger protein 219 isoform X4

    Conserved Domains (5) summary
    sd00017
    Location:459479
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:459479
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:471493
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:485508
    zf-H2C2_5; C2H2-type zinc-finger domain
    cl25751
    Location:412571
    DUF4045; Domain of unknown function (DUF4045)
  2. XM_005267739.1XP_005267796.1  zinc finger protein 219 isoform X1

    Conserved Domains (4) summary
    sd00017
    Location:546566
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:546566
    zf-C2H2; Zinc finger, C2H2 type
    pfam04959
    Location:350454
    ARS2; Arsenite-resistance protein 2
    pfam13465
    Location:558580
    zf-H2C2_2; Zinc-finger double domain
  3. XM_024449625.1XP_024305393.1  zinc finger protein 219 isoform X4

    Conserved Domains (5) summary
    sd00017
    Location:459479
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:459479
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:471493
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:485508
    zf-H2C2_5; C2H2-type zinc-finger domain
    cl25751
    Location:412571
    DUF4045; Domain of unknown function (DUF4045)
  4. XM_024449624.1XP_024305392.1  zinc finger protein 219 isoform X4

    Conserved Domains (5) summary
    sd00017
    Location:459479
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:459479
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:471493
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:485508
    zf-H2C2_5; C2H2-type zinc-finger domain
    cl25751
    Location:412571
    DUF4045; Domain of unknown function (DUF4045)
  5. XM_011536825.1XP_011535127.1  zinc finger protein 219 isoform X2

    Conserved Domains (4) summary
    sd00017
    Location:537557
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:537557
    zf-C2H2; Zinc finger, C2H2 type
    pfam04959
    Location:341445
    ARS2; Arsenite-resistance protein 2
    pfam13465
    Location:549571
    zf-H2C2_2; Zinc-finger double domain
  6. XM_017021354.1XP_016876843.1  zinc finger protein 219 isoform X3

    UniProtKB/Swiss-Prot
    Q9P2Y4
    Conserved Domains (4) summary
    sd00017
    Location:500520
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:500520
    zf-C2H2; Zinc finger, C2H2 type
    pfam04959
    Location:304408
    ARS2; Arsenite-resistance protein 2
    pfam13465
    Location:512534
    zf-H2C2_2; Zinc-finger double domain
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