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LUZP4 leucine zipper protein 4 [ Homo sapiens (human) ]

Gene ID: 51213, updated on 12-Oct-2019

Summary

Official Symbol
LUZP4provided by HGNC
Official Full Name
leucine zipper protein 4provided by HGNC
Primary source
HGNC:HGNC:24971
See related
Ensembl:ENSG00000102021 MIM:300616
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT-8; CT28; CT-28; HOM-TES-85
Summary
This gene encodes a leucine-zipper protein that was first defined as a cancer testis antigens. The encoded protein is an RNA binding protein that interacts with the mRNA export receptor nuclear RNA export factor 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Expression
Restricted expression toward testis (RPKM 5.6) See more
Orthologs

Genomic context

See LUZP4 in Genome Data Viewer
Location:
Xq23
Exon count:
4
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (115289715..115307563)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (114524292..114542121)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene leucine rich repeats and calponin homology domain containing 2 Neighboring gene RBMX like 3 Neighboring gene ribosomal protein L36 pseudogene 18 Neighboring gene uncharacterized LOC107985681 Neighboring gene tubulin alpha 1a pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
mRNA transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leucine zipper protein 4
Names
HOM-TES-85 tumor antigen
cancer/testis antigen 28
tumor antigen HOM-TES-85

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021297.2 RefSeqGene

    Range
    4995..22843
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001318840.2NP_001305769.1  leucine zipper protein 4 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region which results in the use of a an alternate 5' most exon and a frameshift in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC239923, AF124430, AK093369, DB035084
    UniProtKB/Swiss-Prot
    Q9P127
    Conserved Domains (1) summary
    pfam12316
    Location:48147
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal
  2. NM_016383.5NP_057467.1  leucine zipper protein 4 isoform 1

    See identical proteins and their annotated locations for NP_057467.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC239923, AF124430, AK093369, DB035084
    Consensus CDS
    CCDS14567.1
    UniProtKB/Swiss-Prot
    Q9P127
    Related
    ENSP00000360988.3, ENST00000371920.4
    Conserved Domains (1) summary
    pfam07078
    Location:14116
    FYTT; Forty-two-three protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    115289715..115307563
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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