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DUSP13 dual specificity phosphatase 13 [ Homo sapiens (human) ]

Gene ID: 51207, updated on 8-Dec-2018

Summary

Official Symbol
DUSP13provided by HGNC
Official Full Name
dual specificity phosphatase 13provided by HGNC
Primary source
HGNC:HGNC:19681
See related
Ensembl:ENSG00000079393 MIM:613191
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BEDP; MDSP; TMDP; SKRP4; DUSP13A; DUSP13B
Summary
Members of the protein-tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This superfamily is separated into two families based on the substrate that is dephosphorylated. One family, the dual specificity phosphatases (DSPs) acts on both phosphotyrosine and phosphoserine/threonine residues. This gene encodes different but related DSP proteins through the use of non-overlapping open reading frames, alternate splicing, and presumed different transcription promoters. Expression of the distinct proteins from this gene has been found to be tissue specific and the proteins may be involved in postnatal development of specific tissues. A protein encoded by the upstream ORF was found in skeletal muscle, whereas the encoded protein from the downstream ORF was found only in testis. In mouse, a similar pattern of expression was found. Multiple alternatively spliced transcript variants were described, but the full-length sequence of only some were determined. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 6.3), heart (RPKM 1.5) and 3 other tissues See more
Orthologs

Genomic context

See DUSP13 in Genome Data Viewer
Location:
10q22.2
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (75094432..75109221, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (76854190..76868976, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene lysine acetyltransferase 6B Neighboring gene dual specificity phosphatase and pro isomerase domain containing 1 Neighboring gene peptidylprolyl isomerase A pseudogene 13 Neighboring gene sterile alpha motif domain containing 8 Neighboring gene ribosomal protein S26 pseudogene 42 Neighboring gene Sharpr-MPRA regulatory region 7934 Neighboring gene voltage dependent anion channel 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32450

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
meiotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
spermatogenesis TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
dual specificity protein phosphatase 13
Names
branching-enzyme interacting DSP
branching-enzyme interacting dual-specificity protein phosphatase
muscle-restricted DSP
testis- and skeletal-muscle-specific DSP
NP_001007272.1
NP_001007273.1
NP_001007274.1
NP_001307771.1
NP_001307772.1
NP_057448.3
XP_005269940.1
XP_005269941.3
XP_005269944.1
XP_005269947.1
XP_011538155.1
XP_011538156.1
XP_011538157.1
XP_011538158.1
XP_016871802.1
XP_016871803.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033976.1 RefSeqGene

    Range
    5001..19781
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001007271.1NP_001007272.1  dual specificity protein phosphatase 13 isoform 1

    See identical proteins and their annotated locations for NP_001007272.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1, also called MDSP. Isoform 1 is expressed from the upstream open reading frame and is expressed in skeletal muscle.
    Source sequence(s)
    AI971328, AK127886, AY674051
    Consensus CDS
    CCDS53542.1
    UniProtKB/Swiss-Prot
    Q6B8I1
    Related
    ENSP00000361787.2, ENST00000372702.7
    Conserved Domains (1) summary
    cd00127
    Location:38179
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  2. NM_001007272.1NP_001007273.1  dual specificity protein phosphatase 13 isoform 2

    See identical proteins and their annotated locations for NP_001007273.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks several internal exons, compared to variant 1. The encoded protein, isoform 2 (also called TMDP-L2) has an alternate C-terminus, compared to isoform 1. Efforts to detect expression of isoform 2 were unsuccessful.
    Source sequence(s)
    AI971328, AK127886, AY674051
    Consensus CDS
    CCDS31224.1
    UniProtKB/Swiss-Prot
    Q6B8I1
    Related
    ENSP00000361785.2, ENST00000372700.7
    Conserved Domains (1) summary
    cd00127
    Location:95238
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  3. NM_001007273.1NP_001007274.1  dual specificity protein phosphatase 13 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001007274.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks several internal exons, compared to variant 1, resulting in a distinct protein (isoform 3, also called TMDP-L1), compared to isoform 1. Efforts to detect expression of isoform 3 were unsuccessful. Both variants 3 and 7 encode the same isoform (3).
    Source sequence(s)
    AI971328, AK127886, AY674051, BU580940
    UniProtKB/Swiss-Prot
    Q6B8I1
    Conserved Domains (1) summary
    cd00127
    Location:138281
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  4. NM_001320842.1NP_001307771.1  dual specificity protein phosphatase 13 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an alternate internal exon compared to variant 1 and encodes a distinct protein (isoform 3, also known as TMDP-L1) from a downstream open reading frame that is shorter compared to isoform 1. Both variants 3 and 7 encode the same isoform (3).
    Source sequence(s)
    AI971328, AK127886, AY674051
    UniProtKB/Swiss-Prot
    Q6B8I1
    Conserved Domains (1) summary
    cd00127
    Location:138281
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  5. NM_001320843.1NP_001307772.1  dual specificity protein phosphatase 13 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks two alternate internal exons compared to variant 1 and encodes a distinct protein (isoform 6, also known as TMDP) from a downstream open reading frame that is shorter compared to isoform 1. Both variants 6 and 8 encode the same isoform (6).
    Source sequence(s)
    AI971328, AK057012, AY674051, DA898973
    Consensus CDS
    CCDS7346.1
    UniProtKB/Swiss-Prot
    Q6B8I1, Q9UII6
    UniProtKB/TrEMBL
    A0A024QZR6
    Related
    ENSP00000475801.2, ENST00000607131.5
    Conserved Domains (1) summary
    cd00127
    Location:45188
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  6. NM_001363514.1NP_001350443.1  dual specificity protein phosphatase 13 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL392111
    Consensus CDS
    CCDS86105.1
    Conserved Domains (1) summary
    cd00127
    Location:181324
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  7. NM_016364.3NP_057448.3  dual specificity protein phosphatase 13 isoform 6

    See identical proteins and their annotated locations for NP_057448.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks several 5' exons and includes an alternate 5' exon, compared to variant 1. The resulting protein, isoform 6, (also called TMDP) is encoded by the downstream ORF of this gene and is found only in testis. Both variants 6 and 8 encode the same isoform (6).
    Source sequence(s)
    AB027004
    Consensus CDS
    CCDS7346.1
    UniProtKB/Swiss-Prot
    Q9UII6
    UniProtKB/TrEMBL
    A0A024QZR6
    Related
    ENSP00000444580.1, ENST00000472493.6
    Conserved Domains (1) summary
    cd00127
    Location:45188
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    75094432..75109221 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539853.1XP_011538155.1  dual specificity protein phosphatase 13 isoform X3

    Conserved Domains (1) summary
    cd00127
    Location:174317
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  2. XM_005269887.1XP_005269944.1  dual specificity protein phosphatase 13 isoform X4

    See identical proteins and their annotated locations for XP_005269944.1

    Conserved Domains (1) summary
    cd00127
    Location:138281
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  3. XM_005269883.3XP_005269940.1  dual specificity protein phosphatase 13 isoform X1

    Conserved Domains (1) summary
    cd00127
    Location:264407
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  4. XM_005269890.1XP_005269947.1  dual specificity protein phosphatase 13 isoform X7

    See identical proteins and their annotated locations for XP_005269947.1

    UniProtKB/Swiss-Prot
    Q9UII6
    UniProtKB/TrEMBL
    A0A024QZR6
    Conserved Domains (1) summary
    cd00127
    Location:45188
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  5. XM_011539854.2XP_011538156.1  dual specificity protein phosphatase 13 isoform X7

    See identical proteins and their annotated locations for XP_011538156.1

    UniProtKB/Swiss-Prot
    Q9UII6
    UniProtKB/TrEMBL
    A0A024QZR6
    Related
    ENSP00000436312.3, ENST00000491677.6
    Conserved Domains (1) summary
    cd00127
    Location:45188
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  6. XM_011539856.2XP_011538158.1  dual specificity protein phosphatase 13 isoform X7

    See identical proteins and their annotated locations for XP_011538158.1

    UniProtKB/Swiss-Prot
    Q9UII6
    UniProtKB/TrEMBL
    A0A024QZR6
    Conserved Domains (1) summary
    cd00127
    Location:45188
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  7. XM_017016313.1XP_016871802.1  dual specificity protein phosphatase 13 isoform X5

  8. XM_005269884.4XP_005269941.3  dual specificity protein phosphatase 13 isoform X2

    UniProtKB/TrEMBL
    U3KQ82
    Related
    ENSP00000475626.1, ENST00000478873.6
    Conserved Domains (1) summary
    cd00127
    Location:181324
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  9. XM_011539855.2XP_011538157.1  dual specificity protein phosphatase 13 isoform X7

    See identical proteins and their annotated locations for XP_011538157.1

    UniProtKB/Swiss-Prot
    Q9UII6
    UniProtKB/TrEMBL
    A0A024QZR6
    Conserved Domains (1) summary
    cd00127
    Location:45188
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  10. XM_017016314.1XP_016871803.1  dual specificity protein phosphatase 13 isoform X6

    Related
    ENSP00000475732.1, ENST00000473072.2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001007274.1: Suppressed sequence

    Description
    NM_001007274.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_001007275.1: Suppressed sequence

    Description
    NM_001007275.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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