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RASGRP2 RAS guanyl releasing protein 2 [ Bos taurus (cattle) ]

Gene ID: 512056, updated on 3-Apr-2024

Summary

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Official Symbol
RASGRP2provided by VGNC
Official Full Name
RAS guanyl releasing protein 2provided by VGNC
Primary source
VGNC:VGNC:33748
See related
BGD:BT23040; Ensembl:ENSBTAG00000001029
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
CalDAG-GEFI
Orthologs
human mouse all
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Genomic context

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See RASGRP2 in Genome Data Viewer
Location:
chromosome: 29
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 29 NC_037356.1 (42969393..42984084, complement)

Chromosome 29 - NC_037356.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 member 12 Neighboring gene neurexin 2 Neighboring gene glycogen phosphorylase, muscle associated Neighboring gene splicing factor 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037356.1 Chromosome 29 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Calcium diacylglycerol guanine nucleotide exchange factor I (CalDAG-GEFI) gene mutations in a thrombopathic Simmental calf. Boudreaux MK, et al. Vet Pathol, 2007 Nov. PMID 18039909
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
RAS guanyl-releasing protein 2
Names
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
calcium and DAG-regulated guanine nucleotide exchange factor I
calcium diacylglycerol guanine nucleotide exchange factor I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099946.1 → NP_001093416.1  RAS guanyl-releasing protein 2

    See identical proteins and their annotated locations for NP_001093416.1

    Status: PROVISIONAL

    Source sequence(s)
    EF633475
    UniProtKB/Swiss-Prot
    A6N9I4
    UniProtKB/TrEMBL
    F1MJ35
    Related
    ENSBTAP00000001368.5, ENSBTAT00000001368.6
    Conserved Domains (4) summary
    smart00147
    Location:150 → 388
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00029
    Location:499 → 548
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:430 → 481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037356.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    42969393..42984084 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010821075.4 → XP_010819377.2  RAS guanyl-releasing protein 2 isoform X4

    UniProtKB/Swiss-Prot
    A6N9I4
    UniProtKB/TrEMBL
    F1MJ35
    Related
    ENSBTAP00000068916.2, ENSBTAT00000073104.2
    Conserved Domains (4) summary
    smart00147
    Location:150 → 388
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00029
    Location:499 → 548
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:430 → 481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  2. XM_059882852.1 → XP_059738835.1  RAS guanyl-releasing protein 2 isoform X1

  3. XM_059882854.1 → XP_059738837.1  RAS guanyl-releasing protein 2 isoform X4

    UniProtKB/Swiss-Prot
    A6N9I4

  4. XM_010821073.4 → XP_010819375.3  RAS guanyl-releasing protein 2 isoform X3

    UniProtKB/TrEMBL
    F1MJ35
    Conserved Domains (4) summary
    smart00147
    Location:211 → 449
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:74 → 182
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00029
    Location:560 → 609
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:491 → 542
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  5. XM_015461265.3 → XP_015316751.2  RAS guanyl-releasing protein 2 isoform X2

    UniProtKB/TrEMBL
    F1MJ35
    Related
    ENSBTAP00000075417.1, ENSBTAT00000131592.1
    Conserved Domains (4) summary
    smart00147
    Location:259 → 497
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:122 → 230
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00029
    Location:608 → 657
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:539 → 590
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  6. XM_010821074.4 → XP_010819376.2  RAS guanyl-releasing protein 2 isoform X4

    UniProtKB/Swiss-Prot
    A6N9I4
    UniProtKB/TrEMBL
    F1MJ35
    Conserved Domains (4) summary
    smart00147
    Location:150 → 388
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00029
    Location:499 → 548
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:430 → 481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  7. XM_010821072.4 → XP_010819374.2  RAS guanyl-releasing protein 2 isoform X4

    UniProtKB/Swiss-Prot
    A6N9I4
    UniProtKB/TrEMBL
    F1MJ35
    Related
    ENSBTAP00000079588.1, ENSBTAT00000107110.1
    Conserved Domains (4) summary
    smart00147
    Location:150 → 388
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00029
    Location:499 → 548
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:430 → 481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6N9I4.1 GenPept UniProtKB/Swiss-Prot:A6N9I4

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