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C5 complement C5 [ Bos taurus (cattle) ]

Gene ID: 512045, updated on 6-May-2021

Summary

Official Symbol
C5provided by VGNC
Official Full Name
complement C5provided by VGNC
Primary source
VGNC:VGNC:49997
See related
BGD:BT12192; Ensembl:ENSBTAG00000012210
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
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Genomic context

Location:
chromosome: 8
Exon count:
41
Annotation release Status Assembly Chr Location
106 current ARS-UCD1.2 (GCF_002263795.1) 8 NC_037335.1 (110338434..110435971, complement)
105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 8 AC_000165.1 (112239720..112336418, complement)

Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112447759 Neighboring gene TNF receptor associated factor 1 Neighboring gene complement C5-like Neighboring gene uncharacterized LOC101906836 Neighboring gene centriolin

Genomic regions, transcripts, and products

General gene information

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in complement activation, alternative pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in complement activation, classical pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
complement C5a anaphylatoxin
Names
complement component C5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166616.1NP_001160088.1  complement C5a anaphylatoxin precursor

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000008
    Related
    ENSBTAP00000016204.6, ENSBTAT00000016204.6
    Conserved Domains (8) summary
    cd00017
    Location:682750
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    cd02896
    Location:9931300
    complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
    pfam00207
    Location:772859
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:126218
    A2M_N; MG2 domain
    pfam07677
    Location:14191507
    A2M_recep; A-macroglobulin receptor
    pfam07678
    Location:10511301
    A2M_comp; A-macroglobulin complement component
    pfam07703
    Location:470610
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    cl02512
    Location:15251674
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...

RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD1.2 Primary Assembly

Genomic

  1. NC_037335.1 Reference ARS-UCD1.2 Primary Assembly

    Range
    110338434..110435971 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024995618.1XP_024851386.1  complement C5a anaphylatoxin isoform X2

    Conserved Domains (6) summary
    cd00017
    Location:478546
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    cd02896
    Location:7891096
    complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
    pfam00207
    Location:568655
    A2M; Alpha-2-macroglobulin family
    pfam07677
    Location:12151303
    A2M_recep; A-macroglobulin receptor
    pfam07703
    Location:266406
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    cl02512
    Location:13211470
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
  2. XM_024995617.1XP_024851385.1  complement C5a anaphylatoxin isoform X1

    Conserved Domains (6) summary
    cd00017
    Location:682750
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    cd02896
    Location:9931300
    complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
    pfam00207
    Location:772859
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:126219
    A2M_N; MG2 domain
    pfam07677
    Location:14191502
    A2M_recep; A-macroglobulin receptor
    pfam07703
    Location:470610
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region

RNA

  1. XR_003035874.1 RNA Sequence

  2. XR_003035873.1 RNA Sequence

  3. XR_003035872.1 RNA Sequence

  4. XR_003035871.1 RNA Sequence

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