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NUSAP1 nucleolar and spindle associated protein 1 [ Homo sapiens (human) ]

Gene ID: 51203, updated on 5-Aug-2022

Summary

Official Symbol
NUSAP1provided by HGNC
Official Full Name
nucleolar and spindle associated protein 1provided by HGNC
Primary source
HGNC:HGNC:18538
See related
Ensembl:ENSG00000137804 MIM:612818; AllianceGenome:HGNC:18538
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LNP; ANKT; SAPL; BM037; NUSAP; Q0310; PRO0310p1
Summary
NUSAP1 is a nucleolar-spindle-associated protein that plays a role in spindle microtubule organization (Raemaekers et al., 2003 [PubMed 12963707]).[supplied by OMIM, Jun 2009]
Expression
Broad expression in bone marrow (RPKM 30.9), lymph node (RPKM 16.8) and 15 other tissues See more
Orthologs
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Genomic context

See NUSAP1 in Genome Data Viewer
Location:
15q15.1
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (41332881..41381046)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (39139045..39187208)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (41625079..41673244)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene calcineurin like EF-hand protein 1 Neighboring gene OIP5 antisense RNA 1 Neighboring gene Opa interacting protein 5 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 1 Neighboring gene RTF1 homolog, Paf1/RNA polymerase II complex component Neighboring gene RNA, U6 small nuclear 1169, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13421

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding HDA PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
nucleolar and spindle-associated protein 1
Names
nucleolar protein ANKT

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243142.2NP_001230071.1  nucleolar and spindle-associated protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001230071.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in both the 5' and central coding regions, compared to variant 1, resulting in an isoform (4) that is 2 aa shorter than isoform 1.
    Source sequence(s)
    AK222819, BC024772, DB046574
    Consensus CDS
    CCDS58356.1
    UniProtKB/Swiss-Prot
    Q9BXS6
    Related
    ENSP00000454097.1, ENST00000560747.5
    Conserved Domains (1) summary
    pfam16006
    Location:158434
    NUSAP; Nucleolar and spindle-associated protein
  2. NM_001243143.2NP_001230072.1  nucleolar and spindle-associated protein 1 isoform 5

    See identical proteins and their annotated locations for NP_001230072.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (5) that is shorter than isoform 1.
    Source sequence(s)
    AC087721, AL833611, DB046574
    Consensus CDS
    CCDS58357.1
    UniProtKB/Swiss-Prot
    Q9BXS6
    Related
    ENSP00000260359.6, ENST00000260359.10
    Conserved Domains (1) summary
    pfam16006
    Location:144421
    NUSAP; Nucleolar and spindle-associated protein
  3. NM_001243144.2NP_001230073.1  nucleolar and spindle-associated protein 1 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an alternate in-frame exon in both the 5' and 3' coding regions, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (6) is shorter than isoform 1.
    Source sequence(s)
    AC087721, AK293168, BC001308
    Consensus CDS
    CCDS58358.1
    UniProtKB/Swiss-Prot
    Q9BXS6
    Related
    ENSP00000401014.2, ENST00000450592.6
    Conserved Domains (1) summary
    pfam16006
    Location:136373
    NUSAP; Nucleolar and spindle-associated protein
  4. NM_001301136.2NP_001288065.1  nucleolar and spindle-associated protein 1 isoform 7

    See identical proteins and their annotated locations for NP_001288065.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (7) that is 1 aa shorter than isoform 1.
    Source sequence(s)
    BC012887, DB046574
    Consensus CDS
    CCDS73708.1
    UniProtKB/Swiss-Prot
    Q9BXS6
    Related
    ENSP00000453657.1, ENST00000560177.5
    Conserved Domains (1) summary
    pfam16006
    Location:158435
    NUSAP; Nucleolar and spindle-associated protein
  5. NM_016359.5NP_057443.2  nucleolar and spindle-associated protein 1 isoform 1

    See identical proteins and their annotated locations for NP_057443.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF290612, DB046574
    Consensus CDS
    CCDS45234.1
    UniProtKB/Swiss-Prot
    Q9BXS6, Q9UI70
    Related
    ENSP00000453403.1, ENST00000559596.6
    Conserved Domains (1) summary
    pfam16006
    Location:159436
    NUSAP; Nucleolar and spindle-associated protein
  6. NM_018454.8NP_060924.4  nucleolar and spindle-associated protein 1 isoform 2

    See identical proteins and their annotated locations for NP_060924.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
    Source sequence(s)
    BC001308, DB046574
    Consensus CDS
    CCDS45236.1
    UniProtKB/Swiss-Prot
    Q9BXS6
    Related
    ENSP00000400746.2, ENST00000414849.6
    Conserved Domains (1) summary
    pfam16006
    Location:159435
    NUSAP; Nucleolar and spindle-associated protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    41332881..41381046
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006720559.4XP_006720622.1  nucleolar and spindle-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006720622.1

    Conserved Domains (1) summary
    pfam16006
    Location:165442
    NUSAP; Nucleolar and spindle-associated protein
  2. XM_006720562.4XP_006720625.1  nucleolar and spindle-associated protein 1 isoform X8

    Conserved Domains (1) summary
    pfam16006
    Location:165403
    NUSAP; Nucleolar and spindle-associated protein
  3. XM_005254428.4XP_005254485.1  nucleolar and spindle-associated protein 1 isoform X2

    Conserved Domains (1) summary
    pfam16006
    Location:165441
    NUSAP; Nucleolar and spindle-associated protein
  4. XM_005254431.4XP_005254488.1  nucleolar and spindle-associated protein 1 isoform X9

    Conserved Domains (1) summary
    pfam16006
    Location:165402
    NUSAP; Nucleolar and spindle-associated protein
  5. XM_047432641.1XP_047288597.1  nucleolar and spindle-associated protein 1 isoform X10

  6. XM_006720563.4XP_006720626.1  nucleolar and spindle-associated protein 1 isoform X11

    Conserved Domains (1) summary
    pfam16006
    Location:159396
    NUSAP; Nucleolar and spindle-associated protein
  7. XM_006720560.5XP_006720623.1  nucleolar and spindle-associated protein 1 isoform X3

    Conserved Domains (1) summary
    pfam16006
    Location:164441
    NUSAP; Nucleolar and spindle-associated protein
  8. XM_047432639.1XP_047288595.1  nucleolar and spindle-associated protein 1 isoform X4

  9. XM_047432642.1XP_047288598.1  nucleolar and spindle-associated protein 1 isoform X12

  10. XM_047432643.1XP_047288599.1  nucleolar and spindle-associated protein 1 isoform X13

  11. XM_006720561.4XP_006720624.1  nucleolar and spindle-associated protein 1 isoform X5

    Conserved Domains (1) summary
    pfam16006
    Location:150427
    NUSAP; Nucleolar and spindle-associated protein
  12. XM_047432644.1XP_047288600.1  nucleolar and spindle-associated protein 1 isoform X14

  13. XM_047432640.1XP_047288596.1  nucleolar and spindle-associated protein 1 isoform X6

  14. XM_047432645.1XP_047288601.1  nucleolar and spindle-associated protein 1 isoform X15

  15. XM_047432646.1XP_047288602.1  nucleolar and spindle-associated protein 1 isoform X16

  16. XM_005254430.6XP_005254487.1  nucleolar and spindle-associated protein 1 isoform X7

    UniProtKB/Swiss-Prot
    Q9BXS6
    Conserved Domains (1) summary
    pfam16006
    Location:144420
    NUSAP; Nucleolar and spindle-associated protein
  17. XM_017022294.3XP_016877783.1  nucleolar and spindle-associated protein 1 isoform X17

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    39139045..39187208
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001129897.1: Suppressed sequence

    Description
    NM_001129897.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.