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CPA4 carboxypeptidase A4 [ Homo sapiens (human) ]

Gene ID: 51200, updated on 8-Oct-2018

Summary

Official Symbol
CPA4provided by HGNC
Official Full Name
carboxypeptidase A4provided by HGNC
Primary source
HGNC:HGNC:15740
See related
Ensembl:ENSG00000128510 MIM:607635; Vega:OTTHUMG00000157825
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPA3
Summary
This gene is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate cancer aggressiveness. [provided by RefSeq, Jul 2008]
Expression
Biased expression in skin (RPKM 24.3) and esophagus (RPKM 4.3) See more
Orthologs

Genomic context

See CPA4 in Genome Data Viewer
Location:
7q32.2
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (130293134..130324180)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (129932974..129964020)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene transmembrane protein 209 Neighboring gene serine rich single-pass membrane protein 1 Neighboring gene carboxypeptidase A2 Neighboring gene uncharacterized LOC105375503 Neighboring gene uncharacterized LOC105375504 Neighboring gene carboxypeptidase A5 Neighboring gene carboxypeptidase A1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated (2012-07-25)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated (2012-07-25)

ClinGen Genome Curation Page

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metallocarboxypeptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
histone acetylation NAS
Non-traceable Author Statement
more info
PubMed 
proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
carboxypeptidase A4
Names
carboxypeptidase A3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011788.1 RefSeqGene

    Range
    5001..36047
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001163446.1NP_001156918.1  carboxypeptidase A4 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001156918.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1. The encoded isoform (2) lacks a portion of the activation peptide and the carboxypeptidase A4 chain, and lacks the intervening cleavage site compared to isoform 1.
    Source sequence(s)
    AC024085, AK298550, DC368360
    Consensus CDS
    CCDS55163.1
    UniProtKB/Swiss-Prot
    Q9UI42
    Related
    ENSP00000412947.2, ENST00000445470.6
    Conserved Domains (3) summary
    COG2866
    Location:1370
    MpaA; Murein tripeptide amidase MpaA [Cell wall/membrane/envelope biogenesis]
    pfam02244
    Location:2895
    Propep_M14; Carboxypeptidase activation peptide
    cl11393
    Location:95386
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
  2. NM_016352.3NP_057436.2  carboxypeptidase A4 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_057436.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC024085, AK290993
    Consensus CDS
    CCDS5818.1
    UniProtKB/Swiss-Prot
    Q9UI42
    UniProtKB/TrEMBL
    A4D1M3
    Related
    ENSP00000497118.1, OTTHUMP00000212508, ENST00000647977.1, OTTHUMT00000349725
    Conserved Domains (2) summary
    cd03870
    Location:118419
    M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
    pfam02244
    Location:27101
    Propep_M14; Carboxypeptidase activation peptide

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    130293134..130324180
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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