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IPO11 importin 11 [ Homo sapiens (human) ]

Gene ID: 51194, updated on 3-Nov-2019

Summary

Official Symbol
IPO11provided by HGNC
Official Full Name
importin 11provided by HGNC
Primary source
HGNC:HGNC:20628
See related
Ensembl:ENSG00000086200 MIM:610889
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RanBP11
Summary
Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors (see KPNB1; 602738) that mediate nucleocytoplasmic transport of protein and RNA cargoes (Plafker and Macara, 2000 [PubMed 11032817]).[supplied by OMIM, Sep 2008]
Expression
Ubiquitous expression in testis (RPKM 13.7), thyroid (RPKM 6.7) and 25 other tissues See more
Orthologs

Genomic context

See IPO11 in Genome Data Viewer
Location:
5q12.1
Exon count:
31
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (62412746..62628589)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (61699522..61924416)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene CREB regulated transcription coactivator 2 pseudogene Neighboring gene kinesin family member 2A Neighboring gene DIMT1 rRNA methyltransferase and ribosome maturation factor Neighboring gene RNA, U6 small nuclear 661, pseudogene Neighboring gene IPO11-LRRC70 readthrough Neighboring gene CDC28 protein kinase regulatory subunit 1B pseudogene 3 Neighboring gene ribosomal protein L35a pseudogene 14 Neighboring gene leucine rich repeat containing 70 Neighboring gene iron-sulfur cluster assembly 1 pseudogene 1 Neighboring gene dedicator of cytokinesis 9 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide significant association signals in IPO11-HTR1A region specific for alcohol and nicotine codependence.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough IPO11-LRRC70

Readthrough gene: IPO11-LRRC70, Included gene: LRRC70

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Ran GTPase binding IEA
Inferred from Electronic Annotation
more info
 
nuclear import signal receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribosomal protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
importin-11
Names
Ran binding protein 11
imp11
ran-binding protein 11

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134779.1NP_001128251.1  importin-11 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF111109, AK302781, BC033776, BM966917
    Consensus CDS
    CCDS47217.1
    UniProtKB/Swiss-Prot
    Q9UI26
    Related
    ENSP00000386992.3, ENST00000409296.7
    Conserved Domains (3) summary
    COG5657
    Location:501012
    CSE1; CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]
    pfam03810
    Location:68140
    IBN_N; Importin-beta N-terminal domain
    sd00044
    Location:466499
    HEAT; HEAT repeat [structural motif]
  2. NM_016338.4NP_057422.3  importin-11 isoform 2

    See identical proteins and their annotated locations for NP_057422.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream translation initiation codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AF111109, BC033776, BM966917, DA473424
    Consensus CDS
    CCDS34167.1
    UniProtKB/Swiss-Prot
    Q9UI26
    Related
    ENSP00000316651.6, ENST00000325324.10
    Conserved Domains (2) summary
    sd00044
    Location:426459
    HEAT; HEAT repeat [structural motif]
    cl27876
    Location:10972
    Cse1; Cse1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    62412746..62628589
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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