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HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 [ Homo sapiens (human) ]

Gene ID: 51191, updated on 1-Aug-2020

Summary

Official Symbol
HERC5provided by HGNC
Official Full Name
HECT and RLD domain containing E3 ubiquitin protein ligase 5provided by HGNC
Primary source
HGNC:HGNC:24368
See related
Ensembl:ENSG00000138646 MIM:608242
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CEB1; CEBP1
Summary
This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 31.7), endometrium (RPKM 6.3) and 17 other tissues See more
Orthologs

Genomic context

See HERC5 in Genome Data Viewer
Location:
4q22.1
Exon count:
23
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (88456604..88506170)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (89378181..89427334)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377326 Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 Neighboring gene uncharacterized LOC102723458 Neighboring gene nuclear receptor coactivator 4 pseudogene 2 Neighboring gene PIGY upstream reading frame Neighboring gene phosphatidylinositol glycan anchor biosynthesis class Y

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of lung function decline in adults with and without asthma.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Interaction of HIV-1 Gag with HECT and RLD domain containing E3 ubiquitin protein ligase 5 (HERC5) is identified in a series of six affinity purification/mass spectrometry screens PubMed
gag HERC5-induced restriction of Gag particle production is distinct from ISG15-only restriction PubMed
gag HERC5 restricts HIV-1 Gag particle production by a mechanism dependent on its E3 ligase activity. This restriction correlates with the conjugation of ISG15 to Gag by HERC5 PubMed
gag HIV-1 Gag co-localizes with HERC5 in cells PubMed
Rev rev HERC5 relocalizes HIV-1 Rev from nucleus to nuclear membrane and cytoplasm to inhibit Rev/RRE function PubMed
Vpr vpr HIV-1 Vpr upregulates the gene expression of HERC5 in human monocyte-derived dendritic cells PubMed
capsid gag Both HERC5 and HERC5-C994A mutant inhibit HIV-1 particle production with decreased levels of HIV-1 CA in cells and virions PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ISG15 transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ISG15 transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
ISG15-protein conjugation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ISG15-protein conjugation IDA
Inferred from Direct Assay
more info
PubMed 
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of type I interferon production TAS
Traceable Author Statement
more info
 
protein polyubiquitination TAS
Traceable Author Statement
more info
 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cyclin-dependent protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
regulation of defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ISG15--protein ligase HERC5
Names
HECT domain and RCC1-like domain-containing protein 5
cyclin-E-binding protein 1
hect domain and RLD 5
probable E3 ubiquitin-protein ligase HERC5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016323.4NP_057407.2  E3 ISG15--protein ligase HERC5

    See identical proteins and their annotated locations for NP_057407.2

    Status: REVIEWED

    Source sequence(s)
    AC083829, AI336946, AK302142, AY337518, BC140716
    Consensus CDS
    CCDS3630.1
    UniProtKB/Swiss-Prot
    Q9UII4
    UniProtKB/TrEMBL
    B4DXV3
    Related
    ENSP00000264350.3, ENST00000264350.8
    Conserved Domains (4) summary
    smart00119
    Location:7051023
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:6811024
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:261309
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam13540
    Location:140169
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    88456604..88506170
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532022.2XP_011530324.2  E3 ISG15--protein ligase HERC5 isoform X1

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