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RSL24D1 ribosomal L24 domain containing 1 [ Homo sapiens (human) ]

Gene ID: 51187, updated on 7-Jun-2020

Summary

Official Symbol
RSL24D1provided by HGNC
Official Full Name
ribosomal L24 domain containing 1provided by HGNC
Primary source
HGNC:HGNC:18479
See related
Ensembl:ENSG00000137876 MIM:613262
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L30; RLP24; RPL24; TVAS3; RPL24L; C15orf15; HRP-L30-iso
Summary
This gene encodes a protein sharing a low level of sequence similarity with human ribosomal protein L24. Although this gene has been referred to as RPL24, L30, and 60S ribosomal protein L30 isolog in the sequence databases, it is distinct from the human genes officially named RPL24 (which itself has been referred to as ribosomal protein L30) and RPL30. The protein encoded by this gene localizes to the nucleolus and is thought to play a role in the biogenesis of the 60S ribosomal subunit. The precise function of this gene is currently unknown. This gene utilizes alternative polyadenylation signals and has multiple pseudogenes. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in bone marrow (RPKM 88.8), ovary (RPKM 69.7) and 25 other tissues See more
Orthologs

Genomic context

See RSL24D1 in Genome Data Viewer
Location:
15q21.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (55180806..55196941, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (55473512..55489231, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene unc-13 homolog C Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 74 Neighboring gene uncharacterized LOC105370829 Neighboring gene Sharpr-MPRA regulatory region 6285 Neighboring gene RAB27A, member RAS oncogene family Neighboring gene PIGB opposite strand 1 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
assembly of large subunit precursor of preribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribosomal large subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
probable ribosome biogenesis protein RLP24
Names
60S ribosomal protein L30 isolog
homolog of yeast ribosomal like protein 24
my024 protein
ribosomal L24 domain-containing protein 1
NP_057388.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016304.3NP_057388.1  probable ribosome biogenesis protein RLP24

    See identical proteins and their annotated locations for NP_057388.1

    Status: REVIEWED

    Source sequence(s)
    AC011912
    Consensus CDS
    CCDS10152.1
    UniProtKB/Swiss-Prot
    Q9UHA3
    UniProtKB/TrEMBL
    A0A024R5U8
    Related
    ENSP00000260443.4, ENST00000260443.9
    Conserved Domains (1) summary
    pfam01246
    Location:264
    Ribosomal_L24e; Ribosomal protein L24e

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    55180806..55196941 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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