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PCOLCE procollagen C-endopeptidase enhancer [ Homo sapiens (human) ]

Gene ID: 5118, updated on 18-Aug-2020

Summary

Official Symbol
PCOLCEprovided by HGNC
Official Full Name
procollagen C-endopeptidase enhancerprovided by HGNC
Primary source
HGNC:HGNC:8738
See related
Ensembl:ENSG00000106333 MIM:600270
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PCPE; PCPE1; PCPE-1
Summary
Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino- and carboxyl-terminal peptide extensions known as N- and C-propeptides, respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils. This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens C-proteinase activity. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in gall bladder (RPKM 64.6), endometrium (RPKM 44.2) and 21 other tissues See more
Orthologs

Genomic context

See PCOLCE in Genome Data Viewer
Location:
7q22.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (100602363..100608175)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100199882..100205798)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene leucine rich repeats and calponin homology domain containing 4 Neighboring gene ZO-2 associated speckle protein Neighboring gene F-box protein 24 Neighboring gene PCOLCE antisense RNA 1 Neighboring gene motile sperm domain containing 3 Neighboring gene Sharpr-MPRA regulatory region 4647 Neighboring gene transferrin receptor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
collagen binding IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
peptidase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
positive regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
procollagen C-endopeptidase enhancer 1
Names
procollagen C-proteinase enhancer 1
procollagen COOH-terminal proteinase enhancer 1
procollagen, type 1, COOH-terminal proteinase enhancer
type 1 procollagen C-proteinase enhancer protein
type I procollagen COOH-terminal proteinase enhancer

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002593.4NP_002584.2  procollagen C-endopeptidase enhancer 1 precursor

    See identical proteins and their annotated locations for NP_002584.2

    Status: REVIEWED

    Source sequence(s)
    BC000574, BC033205, BI837971
    Consensus CDS
    CCDS5700.1
    UniProtKB/Swiss-Prot
    Q15113
    Related
    ENSP00000223061.5, ENST00000223061.6
    Conserved Domains (2) summary
    cd00041
    Location:37147
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd03576
    Location:313437
    NTR_PCOLCE; NTR domain, PCOLCE subfamily; Procollagen C-endopeptidase enhancers (PCOLCEs) are extracellular matrix proteins that enhance the activity of procollagen C-proteases, by binding to the procollagen I C-peptide. They contain a C-terminal NTR domain, which ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    100602363..100608175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446785.1XP_024302553.1  procollagen C-endopeptidase enhancer 1 isoform X1

    Conserved Domains (2) summary
    cd00041
    Location:2094
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd03576
    Location:137261
    NTR_PCOLCE; NTR domain, PCOLCE subfamily; Procollagen C-endopeptidase enhancers (PCOLCEs) are extracellular matrix proteins that enhance the activity of procollagen C-proteases, by binding to the procollagen I C-peptide. They contain a C-terminal NTR domain, which ...
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