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PLEKHO1 pleckstrin homology domain containing O1 [ Homo sapiens (human) ]

Gene ID: 51177, updated on 5-Aug-2018

Summary

Official Symbol
PLEKHO1provided by HGNC
Official Full Name
pleckstrin homology domain containing O1provided by HGNC
Primary source
HGNC:HGNC:24310
See related
Ensembl:ENSG00000023902 MIM:608335; Vega:OTTHUMG00000012510
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JBP; CKIP1; OC120; CKIP-1
Expression
Broad expression in testis (RPKM 30.7), appendix (RPKM 29.1) and 24 other tissues See more
Orthologs

Genomic context

See PLEKHO1 in Genome Data Viewer
Location:
1q21.2
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (150149434..150160065)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (150122170..150131825)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371427 Neighboring gene ribosomal protein L6 pseudogene Neighboring gene vacuolar protein sorting 45 homolog Neighboring gene uncharacterized LOC105371433 Neighboring gene RNA, 7SL, cytoplasmic 480, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
lamellipodium morphogenesis IEA
Inferred from Electronic Annotation
more info
 
myoblast fusion IEA
Inferred from Electronic Annotation
more info
 
myoblast migration IEA
Inferred from Electronic Annotation
more info
 
regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
muscle cell projection membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
ruffle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
pleckstrin homology domain-containing family O member 1
Names
C-Jun-binding protein
CK2 interacting protein 1; HQ0024c protein
CK2-interacting protein 1
PH domain-containing family O member 1
casein kinase 2-interacting protein 1
osteoclast maturation-associated gene 120 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304722.1NP_001291651.1  pleckstrin homology domain-containing family O member 1 isoform b

    See identical proteins and their annotated locations for NP_001291651.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate first exon in place of that of variant 1, which causes translation initiation at a downstream AUG. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AF192912, AK025937, BX353413, BX376480, BX394578, DA604331
    UniProtKB/Swiss-Prot
    Q53GL0
  2. NM_001304723.1NP_001291652.1  pleckstrin homology domain-containing family O member 1 isoform b

    See identical proteins and their annotated locations for NP_001291652.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks the first exon and retains intronic sequence at the 5' end compared to variant 1, which causes translation initiation at a downstream AUG. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AF192912, AK025937, BP329810, DB023901
    UniProtKB/Swiss-Prot
    Q53GL0
  3. NM_001304724.1NP_001291653.1  pleckstrin homology domain-containing family O member 1 isoform c

    See identical proteins and their annotated locations for NP_001291653.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate 3' exon and uses an alternate first exon in place of that of variant 1, which causes translation initiation at a downstream AUG. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AK025937, BC023533, BX353413, BX376480
    Consensus CDS
    CCDS76210.1
    UniProtKB/Swiss-Prot
    Q53GL0
    UniProtKB/TrEMBL
    Q5T4P9
    Related
    ENSP00000358122.1, OTTHUMP00000014481, ENST00000369126.5, OTTHUMT00000034963
  4. NM_016274.5NP_057358.2  pleckstrin homology domain-containing family O member 1 isoform a

    See identical proteins and their annotated locations for NP_057358.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AF192912, AK025937, HY006501
    Consensus CDS
    CCDS945.1
    UniProtKB/Swiss-Prot
    Q53GL0
    Related
    ENSP00000358120.4, OTTHUMP00000014480, ENST00000369124.4, OTTHUMT00000034962
    Conserved Domains (1) summary
    cd13317
    Location:18127
    PH_PLEKHO1_PLEKHO2; Pleckstrin homology domain-containing family O Pleckstrin homology domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    150149434..150160065
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447478.1XP_024303246.1  pleckstrin homology domain-containing family O member 1 isoform X1

  2. XM_017001420.2XP_016856909.1  pleckstrin homology domain-containing family O member 1 isoform X2

    UniProtKB/Swiss-Prot
    Q53GL0
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