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TUBE1 tubulin epsilon 1 [ Homo sapiens (human) ]

Gene ID: 51175, updated on 23-Nov-2023


Official Symbol
TUBE1provided by HGNC
Official Full Name
tubulin epsilon 1provided by HGNC
Primary source
See related
Ensembl:ENSG00000074935 MIM:607345; AllianceGenome:HGNC:20775
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TUBE; dJ142L7.2
This gene encodes a member of the tubulin superfamily. This protein localizes to the centriolar sub-distal appendages that are associated with the older of the two centrioles after centrosome duplication. This protein plays a central role in organization of the microtubules during centriole duplication. A pseudogene of this gene is found on chromosome 5.[provided by RefSeq, Jan 2009]
Broad expression in testis (RPKM 21.9), endometrium (RPKM 10.2) and 25 other tissues See more
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Genomic context

See TUBE1 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (112070663..112087482, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (113254081..113270900, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (112391866..112408685, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377947 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24958 Neighboring gene Sharpr-MPRA regulatory region 11311 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17484 Neighboring gene cellular communication network factor 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24959 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:112408399-112408930 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:112421446-112422235 Neighboring gene family with sequence similarity 229 member B Neighboring gene MPRA-validated peak6040 silencer Neighboring gene MPRA-validated peak6041 silencer Neighboring gene uncharacterized LOC107986633 Neighboring gene laminin subunit alpha 4 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:112462018-112463217

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat K29A, K50R, and K51R lysine mutations downregulate the proportion of soluble tubulin in cells, while the majority of other lysine mutations upregulate the percentage of soluble tubulin compared with the wild-type PubMed
tat HIV-1 Tat (specifically, amino acids 38-72), enhances tubulin polymerization and triggers the mitochondrial pathway to induce T cell apoptosis as shown in vitro by the release of cytochrome c from isolated mitochondria PubMed

Go to the HIV-1, Human Interaction Database


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Clone Names

  • FLJ22589, FLJ44203

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
Process Evidence Code Pubs
involved_in centrosome cycle TAS
Traceable Author Statement
more info
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
located_in pericentriolar material TAS
Traceable Author Statement
more info

General protein information

Preferred Names
tubulin epsilon chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016262.5NP_057346.1  tubulin epsilon chain

    See identical proteins and their annotated locations for NP_057346.1

    Status: REVIEWED

    Source sequence(s)
    AK026242, BC025405, CA411886
    Consensus CDS
    Q5H8W8, Q8NEG3, Q9UJT0
    ENSP00000357651.5, ENST00000368662.10
    Conserved Domains (1) summary
    epsilon_tubulin; The epsilon-tubulin family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    112070663..112087482 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418855.1XP_047274811.1  tubulin epsilon chain isoform X2

  2. XM_047418854.1XP_047274810.1  tubulin epsilon chain isoform X1

Alternate T2T-CHM13v2.0


  1. NC_060930.1 Alternate T2T-CHM13v2.0

    113254081..113270900 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054355563.1XP_054211538.1  tubulin epsilon chain isoform X2

  2. XM_054355562.1XP_054211537.1  tubulin epsilon chain isoform X1