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TUBE1 tubulin epsilon 1 [ Homo sapiens (human) ]

Gene ID: 51175, updated on 20-Dec-2019

Summary

Official Symbol
TUBE1provided by HGNC
Official Full Name
tubulin epsilon 1provided by HGNC
Primary source
HGNC:HGNC:20775
See related
Ensembl:ENSG00000074935 MIM:607345
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TUBE; dJ142L7.2
Summary
This gene encodes a member of the tubulin superfamily. This protein localizes to the centriolar sub-distal appendages that are associated with the older of the two centrioles after centrosome duplication. This protein plays a central role in organization of the microtubules during centriole duplication. A pseudogene of this gene is found on chromosome 5.[provided by RefSeq, Jan 2009]
Expression
Broad expression in testis (RPKM 21.9), endometrium (RPKM 10.2) and 25 other tissues See more
Orthologs

Genomic context

See TUBE1 in Genome Data Viewer
Location:
6q21
Exon count:
13
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (112070663..112087529, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (112391860..112408751, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377947 Neighboring gene cellular communication network factor 6 Neighboring gene family with sequence similarity 229 member B Neighboring gene uncharacterized LOC107986633 Neighboring gene laminin subunit alpha 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat K29A, K50R, and K51R lysine mutations downregulate the proportion of soluble tubulin in cells, while the majority of other lysine mutations upregulate the percentage of soluble tubulin compared with the wild-type PubMed
tat HIV-1 Tat (specifically, amino acids 38-72), enhances tubulin polymerization and triggers the mitochondrial pathway to induce T cell apoptosis as shown in vitro by the release of cytochrome c from isolated mitochondria PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22589, FLJ44203

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IEA
Inferred from Electronic Annotation
more info
 
structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
centrosome cycle TAS
Traceable Author Statement
more info
PubMed 
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule-based process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pericentriolar material TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
tubulin epsilon chain
Names
epsilon-tubulin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016262.5NP_057346.1  tubulin epsilon chain

    See identical proteins and their annotated locations for NP_057346.1

    Status: REVIEWED

    Source sequence(s)
    AK026242, BC025405, CA411886
    Consensus CDS
    CCDS5100.1
    UniProtKB/Swiss-Prot
    Q9UJT0
    Related
    ENSP00000357651.5, ENST00000368662.10
    Conserved Domains (1) summary
    cd02190
    Location:2457
    epsilon_tubulin; The epsilon-tubulin family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    112070663..112087529 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535875.2XP_011534177.1  tubulin epsilon chain isoform X2

    Conserved Domains (1) summary
    cd02190
    Location:1382
    epsilon_tubulin; The epsilon-tubulin family
  2. XM_017010918.1XP_016866407.1  tubulin epsilon chain isoform X1

    Conserved Domains (1) summary
    cd02190
    Location:10413
    epsilon_tubulin; The epsilon-tubulin family
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