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TUBD1 tubulin delta 1 [ Homo sapiens (human) ]

Gene ID: 51174, updated on 10-Jun-2018
Official Symbol
TUBD1provided by HGNC
Official Full Name
tubulin delta 1provided by HGNC
Primary source
HGNC:HGNC:16811
See related
Ensembl:ENSG00000108423 MIM:607344; Vega:OTTHUMG00000179885
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TUBD
Expression
Ubiquitous expression in esophagus (RPKM 3.8), thyroid (RPKM 3.7) and 25 other tissues See more
Orthologs
See TUBD1 in Genome Data Viewer
Location:
17q23.1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (59859467..59892948, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (57936840..57970306, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene vacuole membrane protein 1 Neighboring gene RNA, U6 small nuclear 450, pseudogene Neighboring gene microRNA 21 Neighboring gene NADH:ubiquinone oxidoreductase subunit B8 pseudogene 2 Neighboring gene ribosomal protein S6 kinase B1 Neighboring gene ribosomal protein S29 pseudogene 21 Neighboring gene TBC1D3P1-DHX40P1 readthrough, transcribed pseudogene Neighboring gene ring finger protein, transmembrane 1

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat K29A, K50R, and K51R lysine mutations downregulate the proportion of soluble tubulin in cells, while the majority of other lysine mutations upregulate the percentage of soluble tubulin compared with the wild-type PubMed
tat HIV-1 Tat (specifically, amino acids 38-72), enhances tubulin polymerization and triggers the mitochondrial pathway to induce T cell apoptosis as shown in vitro by the release of cytochrome c from isolated mitochondria PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ12709

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IEA
Inferred from Electronic Annotation
more info
 
structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell projection organization IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule-based process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule-based process IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smoothened signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
centriole IEA
Inferred from Electronic Annotation
more info
 
cilium IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
Preferred Names
tubulin delta chain
Names
delta-tubulin

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193609.1NP_001180538.1  tubulin delta chain isoform 2

    See identical proteins and their annotated locations for NP_001180538.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate, in-frame, segment, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK024741, BC000258, BG682935, BX119803
    Consensus CDS
    CCDS54153.1
    UniProtKB/Swiss-Prot
    Q9UJT1
    Related
    ENSP00000342399.5, OTTHUMP00000262892, ENST00000340993.10, OTTHUMT00000448812
    Conserved Domains (1) summary
    cd02189
    Location:2397
    delta_zeta_tubulin-like; The delta- and zeta-tubulin families
  2. NM_001193610.1NP_001180539.1  tubulin delta chain isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate, in-frame, segment and uses a different splice site in the 3' coding region, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AB030837, AK024741, AK298492, BG682935, BX119803
    Consensus CDS
    CCDS54154.1
    UniProtKB/Swiss-Prot
    Q9UJT1
    Related
    ENSP00000377785.3, OTTHUMP00000262893, ENST00000394239.7, OTTHUMT00000448813
    Conserved Domains (2) summary
    cd02189
    Location:2395
    delta_zeta_tubulin-like; The delta- and zeta-tubulin families
    pfam00091
    Location:2213
    Tubulin; Tubulin/FtsZ family, GTPase domain
  3. NM_001193611.1NP_001180540.1  tubulin delta chain isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate, in-frame, segments in the 3' coding region, compared to variant 1. The resulting protein (isoform 4) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AB030837, AB031045, AK024741, BG682935, BX119803, DA607129
    Consensus CDS
    CCDS54152.1
    UniProtKB/Swiss-Prot
    Q9UJT1
    Related
    ENSP00000480387.1, ENST00000613721.4
    Conserved Domains (2) summary
    cd02189
    Location:2350
    delta_zeta_tubulin-like; The delta- and zeta-tubulin families
    pfam00091
    Location:2213
    Tubulin; Tubulin/FtsZ family, GTPase domain
  4. NM_001193612.1NP_001180541.1  tubulin delta chain isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate exon in the 5' end, which results in the use of a downstream start codon, and lacks an alternate, in-frame segment in the 3' coding region, compared to variant 1. The resulting protein (isoform 5) has a shorter N-terminus when it is compared to isoform 1.
    Source sequence(s)
    AB030837, AK024741, AK315172, BG682935, BX119803, DA607129
    UniProtKB/Swiss-Prot
    Q9UJT1
    Conserved Domains (2) summary
    cd02189
    Location:1278
    delta_zeta_tubulin-like; The delta- and zeta-tubulin families
    pfam00091
    Location:194
    Tubulin; Tubulin/FtsZ family, GTPase domain
  5. NM_001193613.1NP_001180542.1  tubulin delta chain isoform 6

    See identical proteins and their annotated locations for NP_001180542.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks three alternate exons in the 5' coding region, which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 6) has a shorter N-terminus when it is compared to isoform 1.
    Source sequence(s)
    AB030837, AK024741, AK301312, BG682935, BX119803
    Consensus CDS
    CCDS54151.1
    UniProtKB/Swiss-Prot
    Q9UJT1
    Related
    ENSP00000441757.1, OTTHUMP00000262896, ENST00000539018.5, OTTHUMT00000448816
    Conserved Domains (1) summary
    cd02189
    Location:1236
    delta_zeta_tubulin-like; The delta- and zeta-tubulin families
  6. NM_016261.3NP_057345.2  tubulin delta chain isoform 1

    See identical proteins and their annotated locations for NP_057345.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
    Source sequence(s)
    AB030837, AK024741, BG682935, BX119803, DA607129
    Consensus CDS
    CCDS11620.1
    UniProtKB/Swiss-Prot
    Q9UJT1
    Related
    ENSP00000320797.3, ENST00000325752.7
    Conserved Domains (2) summary
    cd02189
    Location:2452
    delta_zeta_tubulin-like; The delta- and zeta-tubulin families
    pfam00091
    Location:2213
    Tubulin; Tubulin/FtsZ family, GTPase domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    59859467..59892948 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024720.1XP_016880209.1  tubulin delta chain isoform X6

  2. XM_017024716.2XP_016880205.1  tubulin delta chain isoform X3

  3. XM_017024719.2XP_016880208.1  tubulin delta chain isoform X6

  4. XM_005257425.1XP_005257482.1  tubulin delta chain isoform X2

    Conserved Domains (2) summary
    cd02189
    Location:1385
    delta_zeta_tubulin-like; The delta- and zeta-tubulin families
    pfam00091
    Location:1146
    Tubulin; Tubulin/FtsZ family, GTPase domain
  5. XM_017024718.2XP_016880207.1  tubulin delta chain isoform X5

  6. XM_017024717.2XP_016880206.1  tubulin delta chain isoform X5

  7. XM_011524871.3XP_011523173.1  tubulin delta chain isoform X1

    Conserved Domains (2) summary
    cd02189
    Location:2405
    delta_zeta_tubulin-like; The delta- and zeta-tubulin families
    pfam00091
    Location:2213
    Tubulin; Tubulin/FtsZ family, GTPase domain
  8. XM_024450784.1XP_024306552.1  tubulin delta chain isoform X4

    Conserved Domains (1) summary
    cd02189
    Location:23295
    delta_zeta_tubulin-like; The delta- and zeta-tubulin families
  9. XM_024450783.1XP_024306551.1  tubulin delta chain isoform X4

    Conserved Domains (1) summary
    cd02189
    Location:23295
    delta_zeta_tubulin-like; The delta- and zeta-tubulin families
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