U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

HSD17B11 hydroxysteroid 17-beta dehydrogenase 11 [ Homo sapiens (human) ]

Gene ID: 51170, updated on 6-Oct-2024

Summary

Official Symbol
HSD17B11provided by HGNC
Official Full Name
hydroxysteroid 17-beta dehydrogenase 11provided by HGNC
Primary source
HGNC:HGNC:22960
See related
Ensembl:ENSG00000198189 MIM:612831; AllianceGenome:HGNC:22960
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DHRS8; PAN1B; RETSDR2; SDR16C2; 17BHSD11; 17-BETA-HSD11; 17-BETA-HSDXI
Summary
Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001 [PubMed 11165019]).[supplied by OMIM, Jun 2009]
Expression
Broad expression in small intestine (RPKM 142.3), duodenum (RPKM 102.8) and 22 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See HSD17B11 in Genome Data Viewer
Location:
4q22.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (87336515..87391188, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (90665555..90720229, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (88257667..88312340, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene microRNA 5705 Neighboring gene hydroxysteroid 17-beta dehydrogenase 13 Neighboring gene Sharpr-MPRA regulatory region 11108 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21706 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:88312635-88313207 Neighboring gene RNA, 7SL, cytoplasmic 681, pseudogene Neighboring gene mitochondrial ribosomal protein L19 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21707 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:88343613-88344547 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:88345091-88345594 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:88345595-88346096 Neighboring gene nudix hydrolase 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in androgen catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in estrogen biosynthetic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
estradiol 17-beta-dehydrogenase 11
Names
17-beta-hydroxysteroid dehydrogenase type XI
CTCL tumor antigen HD-CL-03
CTCL-associated antigen HD-CL-03
cutaneous T-cell lymphoma-associated antigen HD-CL-03
dehydrogenase/reductase SDR family member 8
retinal short-chain dehydrogenase/reductase 2
short chain dehydrogenase/reductase family 16C member 2
NP_057329.3
XP_011530323.1
XP_054206127.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016245.5NP_057329.3  estradiol 17-beta-dehydrogenase 11 precursor

    See identical proteins and their annotated locations for NP_057329.3

    Status: VALIDATED

    Source sequence(s)
    AC108516, AF273056, BC014327, BM976691, BU838518
    Consensus CDS
    CCDS3619.1
    UniProtKB/Swiss-Prot
    Q8NBQ5, Q96HF6, Q9UKU4
    UniProtKB/TrEMBL
    D6RCD0
    Related
    ENSP00000351035.4, ENST00000358290.9
    Conserved Domains (1) summary
    cd05339
    Location:38277
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    87336515..87391188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532021.2XP_011530323.1  estradiol 17-beta-dehydrogenase 11 isoform X1

    Conserved Domains (1) summary
    cl21454
    Location:38150
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    90665555..90720229 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350152.1XP_054206127.1  estradiol 17-beta-dehydrogenase 11 isoform X1