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HSD17B11 hydroxysteroid 17-beta dehydrogenase 11 [ Homo sapiens (human) ]

Gene ID: 51170, updated on 9-Jan-2019

Summary

Official Symbol
HSD17B11provided by HGNC
Official Full Name
hydroxysteroid 17-beta dehydrogenase 11provided by HGNC
Primary source
HGNC:HGNC:22960
See related
Ensembl:ENSG00000198189 MIM:612831
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DHRS8; PAN1B; RETSDR2; SDR16C2; 17BHSD11; 17-BETA-HSD11; 17-BETA-HSDXI
Summary
Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001 [PubMed 11165019]).[supplied by OMIM, Jun 2009]
Expression
Broad expression in small intestine (RPKM 142.3), duodenum (RPKM 102.8) and 22 other tissues See more
Orthologs

Genomic context

See HSD17B11 in Genome Data Viewer
Location:
4q22.1
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (87336522..87391303, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (88257691..88312455, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene microRNA 5705 Neighboring gene hydroxysteroid 17-beta dehydrogenase 13 Neighboring gene RNA, 7SL, cytoplasmic 681, pseudogene Neighboring gene mitochondrial ribosomal protein L19 pseudogene Neighboring gene nudix hydrolase 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Estrogen biosynthesis, organism-specific biosystem (from REACTOME)
    Estrogen biosynthesis, organism-specific biosystemIn female vertebrates, estrogens control reproductive system development and reproductive functions (Payne AH and Hales DB, 2004).
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Metabolism of steroid hormones, organism-specific biosystem (from REACTOME)
    Metabolism of steroid hormones, organism-specific biosystemSteroid hormones are synthesized primarily in the adrenal gland and gonads. They regulate energy metabolism and stress responses (glucocorticoids), salt balance (mineralocorticoids), and sexual devel...
  • estradiol biosynthesis I, organism-specific biosystem (from BIOCYC)
    estradiol biosynthesis I, organism-specific biosystemEstrogens are estrone and estradiol, steroid hormones synthesized in the ovaries, breasts, adipose and other tissues that are critical for sexual development and function. They can also act as induce...
  • superpathway of steroid hormone biosynthesis, organism-specific biosystem (from BIOCYC)
    superpathway of steroid hormone biosynthesis, organism-specific biosystemAs their name implies, : Steroid-Hormones "steroid hormones" are steroids that act as hormones. Steroid hormones are divided into five groups based on the receptors to which they bind: : Glucocortico...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
estradiol 17-beta-dehydrogenase activity TAS
Traceable Author Statement
more info
 
steroid dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
steroid dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
androgen catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
estrogen biosynthetic process TAS
Traceable Author Statement
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
estradiol 17-beta-dehydrogenase 11
Names
17-beta-hydroxysteroid dehydrogenase type XI
CTCL tumor antigen HD-CL-03
CTCL-associated antigen HD-CL-03
cutaneous T-cell lymphoma-associated antigen HD-CL-03
dehydrogenase/reductase SDR family member 8
retinal short-chain dehydrogenase/reductase 2
short chain dehydrogenase/reductase family 16C member 2
NP_057329.3
XP_011530323.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016245.5NP_057329.3  estradiol 17-beta-dehydrogenase 11 precursor

    See identical proteins and their annotated locations for NP_057329.3

    Status: VALIDATED

    Source sequence(s)
    AC108516, AF273056, BC014327, BM976691, BU838518
    Consensus CDS
    CCDS3619.1
    UniProtKB/Swiss-Prot
    Q8NBQ5
    Related
    ENSP00000351035.4, ENST00000358290.8
    Conserved Domains (1) summary
    cd05339
    Location:38277
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    87336522..87391303 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532021.1XP_011530323.1  estradiol 17-beta-dehydrogenase 11 isoform X1

    Conserved Domains (1) summary
    cl21454
    Location:38150
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
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