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DNM2 dynamin 2 [ Bos taurus (domestic cattle) ]

Gene ID: 511691, updated on 5-Sep-2025
Official Symbol
DNM2provided by VGNC
Official Full Name
dynamin 2provided by VGNC
Primary source
VGNC:VGNC:28143
See related
EnsemblRapid:ENSBTAG00070016125
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See DNM2 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (15209098..15298846)

Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene interleukin enhancer binding factor 3 Neighboring gene queuine tRNA-ribosyltransferase catalytic subunit 1 Neighboring gene uncharacterized LOC132345698 Neighboring gene microRNA mir-3604-1 Neighboring gene microRNA mir-199a-2 Neighboring gene chromosome 7 C19orf38 homolog Neighboring gene transmembrane p24 trafficking protein 1 Neighboring gene coactivator associated arginine methyltransferase 1 Neighboring gene Yip1 domain family member 2

Genomic Sequence:
NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Dynamin-2 regulates fusion pore expansion and quantal release through a mechanism that involves actin dynamics in neuroendocrine chromaffin cells. González-Jamett AM, et al. PLoS One, 2013. PMID 23940613, Free PMC Article
  2. Mannheimia haemolytica leukotoxin binds to lipid rafts in bovine lymphoblastoid cells and is internalized in a dynamin-2- and clathrin-dependent manner. Atapattu DN, et al. Infect Immun, 2007 Oct. PMID 17682044, Free PMC Article
  3. Dynamin-2-dependent targeting of mannheimia haemolytica leukotoxin to mitochondrial cyclophilin D in bovine lymphoblastoid cells. Atapattu DN, et al. Infect Immun, 2008 Nov. PMID 18765728, Free PMC Article
  4. The proline-rich domain of dynamin-2 is responsible for dynamin-dependent in vitro potentiation of endothelial nitric-oxide synthase activity via selective effects on reductase domain function. Cao S, et al. J Biol Chem, 2003 Feb 21. PMID 12488320
  5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dynamin-2 directs actin polymerization at the exocytosis site where both, in concert, adjust the hormone quantal release.
    Title: Dynamin-2 regulates fusion pore expansion and quantal release through a mechanism that involves actin dynamics in neuroendocrine chromaffin cells.
  2. Knocking down dynamin-2 by small interfering RNA reduced both leukotoxin internalization and cytotoxicity.
    Title: Mannheimia haemolytica leukotoxin binds to lipid rafts in bovine lymphoblastoid cells and is internalized in a dynamin-2- and clathrin-dependent manner.
  3. role of the proline-rich domain of dynamin-2 in in vitro potentiation of endothelial nitric-oxide synthase activity.
    Title: The proline-rich domain of dynamin-2 is responsible for dynamin-dependent in vitro potentiation of endothelial nitric-oxide synthase activity via selective effects on reductase domain function.
  4. LKT-mediated cell death involve dynamin-2 and cyclophilin D
    Title: Dynamin-2-dependent targeting of mannheimia haemolytica leukotoxin to mitochondrial cyclophilin D in bovine lymphoblastoid cells.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in synaptic vesicle endocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
dynamin-2
NP_001092839.1
XP_024849866.1
XP_024849867.1
XP_024849869.1
XP_024849870.1
XP_024849871.1
XP_024849872.1
XP_024849873.1
XP_024849874.1
XP_024849875.1
XP_024849876.1
XP_024849877.1
XP_024849878.1
XP_024849879.1
XP_024849880.1
XP_059744064.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099369.1 → NP_001092839.1  dynamin-2

    See identical proteins and their annotated locations for NP_001092839.1

    Status: PROVISIONAL

    Source sequence(s)
    BC146259
    UniProtKB/Swiss-Prot
    A6H7I5
    UniProtKB/TrEMBL
    F1MW91
    Related
    ENSBTAP00070021274.1, ENSBTAT00070036209.1
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    cd01256
    Location:514 → 625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:647 → 735
    GED; Dynamin GTPase effector domain
    NF033913
    Location:698 → 861
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    15209098..15298846
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024994111.2 → XP_024849879.1  dynamin-2 isoform X12

    UniProtKB/TrEMBL
    F1MW91
    Related
    ENSBTAP00070021295.1, ENSBTAT00070036230.1
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    cd01256
    Location:520 → 629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 501
    Dynamin_M; Dynamin central region
    pfam02212
    Location:651 → 739
    GED; Dynamin GTPase effector domain
    cl26464
    Location:737 → 835
    Atrophin-1; Atrophin-1 family

  2. XM_024994105.2 → XP_024849873.1  dynamin-2 isoform X7

    UniProtKB/TrEMBL
    F1MW91
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    cd01256
    Location:530 → 639
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 498
    Dynamin_M; Dynamin central region
    pfam02212
    Location:661 → 749
    GED; Dynamin GTPase effector domain
    cl26464
    Location:747 → 845
    Atrophin-1; Atrophin-1 family

  3. XM_024994110.2 → XP_024849878.1  dynamin-2 isoform X13

    UniProtKB/TrEMBL
    F1MW91
    Related
    ENSBTAP00070021278.1, ENSBTAT00070036213.1
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    cd01256
    Location:520 → 629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 501
    Dynamin_M; Dynamin central region
    pfam02212
    Location:651 → 739
    GED; Dynamin GTPase effector domain
    cl26464
    Location:737 → 835
    Atrophin-1; Atrophin-1 family

  4. XM_024994099.2 → XP_024849867.1  dynamin-2 isoform X2

    UniProtKB/TrEMBL
    F1MW91
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    cd01256
    Location:530 → 639
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 498
    Dynamin_M; Dynamin central region
    pfam02212
    Location:661 → 749
    GED; Dynamin GTPase effector domain
    cl26464
    Location:749 → 876
    Atrophin-1; Atrophin-1 family

  5. XM_024994104.2 → XP_024849872.1  dynamin-2 isoform X6

    UniProtKB/TrEMBL
    F1MW91
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    cd01256
    Location:520 → 629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 501
    Dynamin_M; Dynamin central region
    pfam02212
    Location:651 → 739
    GED; Dynamin GTPase effector domain
    cl26464
    Location:739 → 866
    Atrophin-1; Atrophin-1 family

  6. XM_024994107.2 → XP_024849875.1  dynamin-2 isoform X9

    UniProtKB/TrEMBL
    F1MW91
    Related
    ENSBTAP00070021292.1, ENSBTAT00070036227.1
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    cd01256
    Location:520 → 629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 501
    Dynamin_M; Dynamin central region
    pfam02212
    Location:651 → 739
    GED; Dynamin GTPase effector domain
    cl26464
    Location:747 → 866
    Atrophin-1; Atrophin-1 family

  7. XM_024994109.2 → XP_024849877.1  dynamin-2 isoform X11

    UniProtKB/TrEMBL
    F1MW91
    Related
    ENSBTAP00070021288.1, ENSBTAT00070036223.1
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    cd01256
    Location:514 → 625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 501
    Dynamin_M; Dynamin central region
    pfam02212
    Location:647 → 735
    GED; Dynamin GTPase effector domain
    cl26464
    Location:743 → 862
    Atrophin-1; Atrophin-1 family

  8. XM_024994098.2 → XP_024849866.1  dynamin-2 isoform X1

    UniProtKB/TrEMBL
    F1MW91
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    cd01256
    Location:530 → 639
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 498
    Dynamin_M; Dynamin central region
    pfam02212
    Location:661 → 749
    GED; Dynamin GTPase effector domain
    cl26464
    Location:749 → 876
    Atrophin-1; Atrophin-1 family

  9. XM_024994101.2 → XP_024849869.1  dynamin-2 isoform X3

    UniProtKB/TrEMBL
    F1MW91
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    cd01256
    Location:530 → 639
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 498
    Dynamin_M; Dynamin central region
    pfam02212
    Location:661 → 749
    GED; Dynamin GTPase effector domain
    cl26464
    Location:757 → 876
    Atrophin-1; Atrophin-1 family

  10. XM_024994102.2 → XP_024849870.1  dynamin-2 isoform X4

    UniProtKB/TrEMBL
    F1MW91
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    cd01256
    Location:524 → 635
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 498
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657 → 745
    GED; Dynamin GTPase effector domain
    cl26464
    Location:745 → 872
    Atrophin-1; Atrophin-1 family

  11. XM_024994103.2 → XP_024849871.1  dynamin-2 isoform X5

    UniProtKB/TrEMBL
    F1MW91
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    cd01256
    Location:520 → 629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 501
    Dynamin_M; Dynamin central region
    pfam02212
    Location:651 → 739
    GED; Dynamin GTPase effector domain
    cl26464
    Location:739 → 866
    Atrophin-1; Atrophin-1 family

  12. XM_024994106.2 → XP_024849874.1  dynamin-2 isoform X8

    UniProtKB/TrEMBL
    F1MW91
    Related
    ENSBTAP00070021281.1, ENSBTAT00070036216.1
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    cd01256
    Location:520 → 629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 501
    Dynamin_M; Dynamin central region
    pfam02212
    Location:651 → 739
    GED; Dynamin GTPase effector domain
    cl26464
    Location:739 → 865
    Atrophin-1; Atrophin-1 family

  13. XM_024994108.2 → XP_024849876.1  dynamin-2 isoform X10

    UniProtKB/TrEMBL
    F1MW91
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    cd01256
    Location:514 → 625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 501
    Dynamin_M; Dynamin central region
    pfam02212
    Location:647 → 735
    GED; Dynamin GTPase effector domain
    cl26464
    Location:735 → 862
    Atrophin-1; Atrophin-1 family

  14. XM_024994112.2 → XP_024849880.1  dynamin-2 isoform X14

    UniProtKB/TrEMBL
    F1MW91
    Conserved Domains (5) summary
    cd08771
    Location:36 → 252
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    cd01256
    Location:488 → 597
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:174 → 456
    Dynamin_M; Dynamin central region
    pfam02212
    Location:619 → 707
    GED; Dynamin GTPase effector domain
    cl26464
    Location:707 → 834
    Atrophin-1; Atrophin-1 family

  15. XM_059888081.1 → XP_059744064.1  dynamin-2 isoform X15

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6H7I5.1 GenPept UniProtKB/Swiss-Prot:A6H7I5

Gene LinkOut

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Research Materials