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CYB5R4 cytochrome b5 reductase 4 [ Homo sapiens (human) ]

Gene ID: 51167, updated on 21-Dec-2019

Summary

Official Symbol
CYB5R4provided by HGNC
Official Full Name
cytochrome b5 reductase 4provided by HGNC
Primary source
HGNC:HGNC:20147
See related
Ensembl:ENSG00000065615 MIM:608343
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NCB5OR; cb5/cb5R; dJ676J13.1
Summary
NCB5OR is a flavohemoprotein that contains functional domains found in both cytochrome b5 (CYB5A; MIM 613218) and CYB5 reductase (CYB5R3; MIM 613213) (Zhu et al., 1999 [PubMed 10611283]).[supplied by OMIM, Jan 2010]
Expression
Broad expression in testis (RPKM 17.2), appendix (RPKM 16.0) and 24 other tissues See more
Orthologs

Genomic context

See CYB5R4 in Genome Data Viewer
Location:
6q14.2
Exon count:
16
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (83859689..83967423)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (84569370..84670146)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377879 Neighboring gene ripply transcriptional repressor 2 Neighboring gene CRISPRi-validated cis-regulatory element chr6.3721 Neighboring gene Sharpr-MPRA regulatory region 12168

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD(P)H oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT NAD(P)H oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
cytochrome-b5 reductase activity, acting on NAD(P)H IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytochrome-b5 reductase activity, acting on NAD(P)H IDA
Inferred from Direct Assay
more info
PubMed 
heme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
bicarbonate transport TAS
Traceable Author Statement
more info
 
cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
detection of oxygen NAS
Non-traceable Author Statement
more info
PubMed 
generation of precursor metabolites and energy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
generation of precursor metabolites and energy IDA
Inferred from Direct Assay
more info
PubMed 
glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
insulin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
oxidation-reduction process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
response to antibiotic ISS
Inferred from Sequence or Structural Similarity
more info
 
superoxide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
superoxide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cytochrome b5 reductase 4
Names
N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein
NADPH cytochrome B5 oxidoreductase
cytochrome b-type NAD(P)H oxidoreductase
flavohemoprotein b5+b5R
flavohemoprotein b5/b5R
NP_057314.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016230.4NP_057314.2  cytochrome b5 reductase 4

    See identical proteins and their annotated locations for NP_057314.2

    Status: VALIDATED

    Source sequence(s)
    AL034347, BC025380, BC029339, DA274558
    Consensus CDS
    CCDS5000.2
    UniProtKB/Swiss-Prot
    Q7L1T6
    Related
    ENSP00000358695.3, ENST00000369681.10
    Conserved Domains (3) summary
    cd06183
    Location:278519
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    cd06490
    Location:170256
    p23_NCB5OR; p23_like domain found in NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR) and similar proteins. NCB5OR is widely expressed in human organs and tissues and is localized in the ER (endoplasmic reticulum). It appears to play a critical role in maintaining ...
    pfam00173
    Location:58130
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    83859689..83967423
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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