Format

Send to:

Choose Destination

DBR1 debranching RNA lariats 1 [ Homo sapiens (human) ]

Gene ID: 51163, updated on 7-Oct-2019

Summary

Official Symbol
DBR1provided by HGNC
Official Full Name
debranching RNA lariats 1provided by HGNC
Primary source
HGNC:HGNC:15594
See related
Ensembl:ENSG00000138231 MIM:607024
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is an RNA lariat debranching enzyme that hydrolyzes 2'-5' prime branched phosphodiester bonds. The encoded protein specifically targets the bonds at the branch point of excised lariat intron RNA, converting them to linear molecules that are then degraded. This protein may also be involved in retroviral replication. [provided by RefSeq, Nov 2011]
Expression
Ubiquitous expression in stomach (RPKM 5.7), bone marrow (RPKM 5.2) and 25 other tissues See more
Orthologs

Genomic context

See DBR1 in Genome Data Viewer
Location:
3q22.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (138160988..138174921, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (137879830..137893791, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene DAZ interacting zinc finger protein 1 like Neighboring gene keratin 8 pseudogene 36 Neighboring gene alpha-1,4-N-acetylglucosaminyltransferase Neighboring gene armadillo repeat containing 8 Neighboring gene NME/NM23 family member 9 Neighboring gene muscle RAS oncogene homolog

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA lariat debranching enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA lariat debranching enzyme activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
RNA phosphodiester bond hydrolysis, endonucleolytic IEA
Inferred from Electronic Annotation
more info
 
RNA splicing, via transesterification reactions IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
lariat debranching enzyme
Names
RNA lariat debranching enzyme
debranching enzyme homolog 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016216.4NP_057300.2  lariat debranching enzyme

    See identical proteins and their annotated locations for NP_057300.2

    Status: REVIEWED

    Source sequence(s)
    AC023049, AL702928, BC009472, BF987317, CD677175
    Consensus CDS
    CCDS33863.1
    UniProtKB/Swiss-Prot
    Q9UK59
    Related
    ENSP00000260803.4, ENST00000260803.9
    Conserved Domains (2) summary
    cd00844
    Location:3264
    MPP_Dbr1_N; Dbr1 RNA lariat debranching enzyme, N-terminal metallophosphatase domain
    pfam05011
    Location:246379
    DBR1; Lariat debranching enzyme, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    138160988..138174921 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center