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MRNIP MRN complex interacting protein [ Homo sapiens (human) ]

Gene ID: 51149, updated on 12-Oct-2019

Summary

Official Symbol
MRNIPprovided by HGNC
Official Full Name
MRN complex interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:30817
See related
Ensembl:ENSG00000161010 MIM:617154
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C5orf45
Expression
Ubiquitous expression in endometrium (RPKM 41.9), lung (RPKM 28.1) and 25 other tissues See more
Orthologs

Genomic context

See MRNIP in Genome Data Viewer
Location:
5q35.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (179837276..179858817, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (179263927..179285867, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene microRNA 1229 Neighboring gene alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B Neighboring gene sequestosome 1 Neighboring gene Sharpr-MPRA regulatory region 15558 Neighboring gene RN7SK pseudogene 150 Neighboring gene uncharacterized LOC100996419 Neighboring gene TBC1 domain family member 9B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of chromosome 5 open reading frame 45 (C5orf45) by siRNA has both activating and inhibiting activities on HIV-1 replication in HeLa P4/R5 cells, suggesting a regulatory role in HIV replication PubMed

Go to the HIV-1, Human Interaction Database

General gene information

Markers

Homology

Clone Names

  • MGC65027, MGC78537, DKFZp686L2452

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with Mre11 complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
MRN complex-interacting protein
Names
MRN-interacting protein
UPF0544 protein C5orf45

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017987.3NP_001017987.1  MRN complex-interacting protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two exons in the coding region, as compared to variant 1. The encoded isoform (2) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    BC050714, BC056889, BC069051, BF965313, BQ642639
    Consensus CDS
    CCDS34318.1
    UniProtKB/Swiss-Prot
    Q6NTE8
    Related
    ENSP00000366130.2, ENST00000376931.6
    Conserved Domains (1) summary
    pfam15749
    Location:943
    UPF0544; uncharacterized protein family UPF0544
  2. NM_016175.4NP_057259.2  MRN complex-interacting protein isoform 1

    See identical proteins and their annotated locations for NP_057259.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC050714, BC069051, BF965313, BQ642639
    Consensus CDS
    CCDS34319.1
    UniProtKB/Swiss-Prot
    Q6NTE8
    Related
    ENSP00000292586.6, ENST00000292586.11
    Conserved Domains (1) summary
    pfam15749
    Location:9107
    UPF0544; uncharacterized protein family UPF0544

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    179837276..179858817 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_016107298.1 Reference GRCh38.p13 PATCHES

    Range
    602836..624377 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001018061.1: Suppressed sequence

    Description
    NM_001018061.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_001018062.1: Suppressed sequence

    Description
    NM_001018062.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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