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CERCAM cerebral endothelial cell adhesion molecule [ Homo sapiens (human) ]

Gene ID: 51148, updated on 25-Jan-2022

Summary

Official Symbol
CERCAMprovided by HGNC
Official Full Name
cerebral endothelial cell adhesion moleculeprovided by HGNC
Primary source
HGNC:HGNC:23723
See related
Ensembl:ENSG00000167123 MIM:616626; AllianceGenome:HGNC:23723
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CEECAM1; GLT25D3
Summary
Enables identical protein binding activity. Acts upstream of or within cell adhesion. Predicted to be located in endoplasmic reticulum lumen. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in brain (RPKM 35.8), placenta (RPKM 14.3) and 19 other tissues See more
Orthologs
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Genomic context

See CERCAM in Genome Data Viewer
Location:
9q34.11
Exon count:
21
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (128405994..128437351)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (131181439..131199630)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ubiquitin related modifier 1 Neighboring gene microRNA 219a-2 Neighboring gene microRNA 219b Neighboring gene protein PAT1 homolog 1-like Neighboring gene outer dense fiber of sperm tails 2 Neighboring gene ODF2 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC149620, MGC149621

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT enables procollagen galactosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in leukocyte cell-cell adhesion TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
inactive glycosyltransferase 25 family member 3
Names
cerebral cell adhesion molecule
cerebral endothelial cell adhesion molecule 1
glycosyltransferase 25 domain containing 3
glycosyltransferase 25 family member 3
probable inactive glycosyltransferase 25 family member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286760.1NP_001273689.1  inactive glycosyltransferase 25 family member 3 isoform b

    See identical proteins and their annotated locations for NP_001273689.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AK314294, BC098432
    Consensus CDS
    CCDS69675.1
    UniProtKB/Swiss-Prot
    Q5T4B2
    Conserved Domains (1) summary
    cd06532
    Location:243425
    Glyco_transf_25; Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of ...
  2. NM_016174.5NP_057258.3  inactive glycosyltransferase 25 family member 3 isoform a precursor

    See identical proteins and their annotated locations for NP_057258.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    BC098432, CX871555
    Consensus CDS
    CCDS6901.2
    UniProtKB/Swiss-Prot
    Q5T4B2
    Related
    ENSP00000361929.4, ENST00000372838.9
    Conserved Domains (2) summary
    cd06532
    Location:321503
    Glyco_transf_25; Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of ...
    cl11394
    Location:3781
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    128405994..128437351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014794.2XP_016870283.1  inactive glycosyltransferase 25 family member 3 isoform X1

    UniProtKB/Swiss-Prot
    Q5T4B2
    Conserved Domains (2) summary
    cd06532
    Location:321503
    Glyco_transf_25; Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of ...
    cl11394
    Location:3781
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
  2. XM_011518762.1XP_011517064.1  inactive glycosyltransferase 25 family member 3 isoform X1

    See identical proteins and their annotated locations for XP_011517064.1

    UniProtKB/Swiss-Prot
    Q5T4B2
    Conserved Domains (2) summary
    cd06532
    Location:321503
    Glyco_transf_25; Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of ...
    cl11394
    Location:3781
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
  3. XM_005252035.1XP_005252092.1  inactive glycosyltransferase 25 family member 3 isoform X1

    See identical proteins and their annotated locations for XP_005252092.1

    UniProtKB/Swiss-Prot
    Q5T4B2
    Conserved Domains (2) summary
    cd06532
    Location:321503
    Glyco_transf_25; Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of ...
    cl11394
    Location:3781
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
  4. XM_024447568.1XP_024303336.1  inactive glycosyltransferase 25 family member 3 isoform X2

    Conserved Domains (1) summary
    cd06532
    Location:243425
    Glyco_transf_25; Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of ...
  5. XM_011518763.3XP_011517065.1  inactive glycosyltransferase 25 family member 3 isoform X2

    See identical proteins and their annotated locations for XP_011517065.1

    UniProtKB/Swiss-Prot
    Q5T4B2
    Related
    ENSP00000361933.1, ENST00000372842.5
    Conserved Domains (1) summary
    cd06532
    Location:243425
    Glyco_transf_25; Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of ...
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