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DYNC1LI1 dynein cytoplasmic 1 light intermediate chain 1 [ Homo sapiens (human) ]

Gene ID: 51143, updated on 1-Jun-2020

Summary

Official Symbol
DYNC1LI1provided by HGNC
Official Full Name
dynein cytoplasmic 1 light intermediate chain 1provided by HGNC
Primary source
HGNC:HGNC:18745
See related
Ensembl:ENSG00000144635 MIM:615890
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LIC1; DLC-A; DNCLI1
Summary
The protein encoded by this gene belongs to light intermediate subunit family, whose members are components of the multiprotein cytoplasmic dynein complex, which is involved in intracellular trafficking and chromosome segregation during mitosis. The protein plays a role in moving the spindle assembly checkpoint (SAC) from kinetochores to spindle poles. The protein may also mediate binding to other cargo molecules to facilitate intracellular vesicle trafficking. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in testis (RPKM 27.3), heart (RPKM 19.1) and 25 other tissues See more
Orthologs

Genomic context

See DYNC1LI1 in Genome Data Viewer
Location:
3p22.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (32525971..32570924, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (32567463..32612373, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene microRNA 548ay Neighboring gene ribosomal protein L31 pseudogene 18 Neighboring gene immunoglobulin (CD79A) binding protein 1 pseudogene 3 Neighboring gene ribosomal protein L30 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr is identified to have a physical interaction with dynein, cytoplasmic 1, light intermediate chain 1 (DYNC1LI1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
capsid gag HIV-1 CA uncoating is delayed in the presence of ciliobrevin D, a specific inhibitor of dynein-mediated motor function, indicating that dynein is involved in CA uncoating in cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10219

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
GDP binding IDA
Inferred from Direct Assay
more info
PubMed 
NOT GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding HDA PubMed 
dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dynein heavy chain binding IPI
Inferred from Physical Interaction
more info
PubMed 
microtubule motor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
Traceable Author Statement
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive regulation of mitotic cell cycle spindle assembly checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
condensed chromosome kinetochore IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic dynein complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
 
kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
secretory granule membrane TAS
Traceable Author Statement
more info
 
spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cytoplasmic dynein 1 light intermediate chain 1
Names
dynein light chain A
dynein light intermediate chain 1, cytosolic
dynein, cytoplasmic, light intermediate polypeptide 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051046.1 RefSeqGene

    Range
    5067..49951
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001329135.1NP_001316064.1  cytoplasmic dynein 1 light intermediate chain 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two consecutive alternate exons in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AK074348, BU521223, HY036998
    Consensus CDS
    CCDS87058.1
    UniProtKB/TrEMBL
    E9PHI6
    Related
    ENSP00000407279.2, ENST00000432458.6
    Conserved Domains (1) summary
    pfam05783
    Location:43403
    DLIC; Dynein light intermediate chain (DLIC)
  2. NM_016141.4NP_057225.2  cytoplasmic dynein 1 light intermediate chain 1 isoform 1

    See identical proteins and their annotated locations for NP_057225.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK074348
    Consensus CDS
    CCDS2654.1
    UniProtKB/Swiss-Prot
    Q9Y6G9
    Related
    ENSP00000273130.4, ENST00000273130.9
    Conserved Domains (1) summary
    pfam05783
    Location:43519
    DLIC; Dynein light intermediate chain (DLIC)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    32525971..32570924 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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