Format

Send to:

Choose Destination

RLIM ring finger protein, LIM domain interacting [ Homo sapiens (human) ]

Gene ID: 51132, updated on 8-Jul-2021

Summary

Official Symbol
RLIMprovided by HGNC
Official Full Name
ring finger protein, LIM domain interactingprovided by HGNC
Primary source
HGNC:HGNC:13429
See related
Ensembl:ENSG00000131263 MIM:300379
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRX61; RNF12; TOKAS; NY-REN-43
Summary
The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be an E3 ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2009]
Expression
Ubiquitous expression in bone marrow (RPKM 10.2), brain (RPKM 9.5) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See RLIM in Genome Data Viewer
Location:
Xq13.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (74582976..74614624, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (73802811..73834459, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373252 Neighboring gene solute carrier family 16 member 2 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 25 Neighboring gene poly(A) binding protein cytoplasmic 1 pseudogene 3 Neighboring gene RNA, U6 small nuclear 330, pseudogene Neighboring gene neurite extension and migration factor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25923, FLJ41093, FLJ42887, FLJ45986, MGC15161, DKFZp686N06224

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription corepressor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of transcription repressor complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RLIM
Names
E3 ubiquitin-protein ligase RNF12
LIM domain-interacting RING finger protein
R-LIM
RING finger LIM domain-binding protein
RING-type E3 ubiquitin transferase RLIM
renal carcinoma antigen NY-REN-43
ring finger protein 12
ring zinc finger LIM domain binding protein
ring zinc finger protein NY-REN-43antigen
NP_057204.2
NP_899196.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013258.1 RefSeqGene

    Range
    5003..36651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_016120.4NP_057204.2  E3 ubiquitin-protein ligase RLIM

    See identical proteins and their annotated locations for NP_057204.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an alternate exon in the 5' UTR, compared to variant 2, and may represent the more abundant form. Both variants encode the same protein.
    Source sequence(s)
    AK127880, AL513007, BC013357, BF686000
    Consensus CDS
    CCDS14427.1
    UniProtKB/Swiss-Prot
    Q9NVW2
    Related
    ENSP00000328059.6, ENST00000332687.11
    Conserved Domains (2) summary
    PHA03307
    Location:159348
    PHA03307; transcriptional regulator ICP4; Provisional
    cl17238
    Location:568612
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  2. NM_183353.3NP_899196.1  E3 ubiquitin-protein ligase RLIM

    See identical proteins and their annotated locations for NP_899196.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longer transcript. Both variants encode the same protein.
    Source sequence(s)
    AK127880, AL513007, AL712605, BC013357, BF686000
    Consensus CDS
    CCDS14427.1
    UniProtKB/Swiss-Prot
    Q9NVW2
    Related
    ENSP00000253571.3, ENST00000349225.2
    Conserved Domains (2) summary
    PHA03307
    Location:159348
    PHA03307; transcriptional regulator ICP4; Provisional
    cl17238
    Location:568612
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    74582976..74614624 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center