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PHF11 PHD finger protein 11 [ Homo sapiens (human) ]

Gene ID: 51131, updated on 5-Jul-2025
Official Symbol
PHF11provided by HGNC
Official Full Name
PHD finger protein 11provided by HGNC
Primary source
HGNC:HGNC:17024
See related
Ensembl:ENSG00000136147 MIM:607796; AllianceGenome:HGNC:17024
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APY; BCAP; IGEL; IGER; IGHER; NYREN34; NY-REN-34
Summary
This gene encodes a protein containing a PHD (plant homeodomain) type zinc finger. This gene has been identified in some studies as a candidate gene for asthma. Naturally-occurring readthrough transcription may occur from the upstream SETDB2 (SET domain bifurcated 2) gene to this locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in lymph node (RPKM 13.0), spleen (RPKM 12.7) and 25 other tissues See more
Orthologs
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See PHF11 in Genome Data Viewer
Location:
13q14.2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (49495953..49528976)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (48714592..48747507)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (50070089..50103112)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:49888093-49889292 Neighboring gene calcium binding protein 39 like Neighboring gene NANOG hESC enhancer GRCh37_chr13:49961302-49961803 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7746 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:50018017-50018789 Neighboring gene SETDB2-PHF11 readthrough Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:50018790-50019563 Neighboring gene SET domain bifurcated histone lysine methyltransferase 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:50068895-50069580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7748 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5342 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7749 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 14 Neighboring gene RCC1 and BTB domain containing protein 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:50139673-50140480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5343 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7750 Neighboring gene uncharacterized LOC105370204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:50194124-50194624

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Readthrough SETDB2-PHF11

Readthrough gene: SETDB2-PHF11, Included gene: SETDB2

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
PHD finger protein 11
Names
BRCA1 C-terminus-associated protein
IgE responsiveness (atopic)
renal carcinoma antigen NY-REN-34

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040443.3NP_001035533.1  PHD finger protein 11 isoform a

    See identical proteins and their annotated locations for NP_001035533.1

    Status: REVIEWED

    Source sequence(s)
    AK026228, DA652444
    Consensus CDS
    CCDS31975.1
    UniProtKB/Swiss-Prot
    Q5W0A4, Q5W0A6, Q9UIL8, Q9Y5A2
    Related
    ENSP00000367570.3, ENST00000378319.8
    Conserved Domains (1) summary
    cd15712
    Location:45159
    ePHD_PHF11; Extended PHD finger found in PHD finger protein 11 (PHF11)
  2. NM_001040444.3NP_001035534.1  PHD finger protein 11 isoform b

    See identical proteins and their annotated locations for NP_001035534.1

    Status: REVIEWED

    Source sequence(s)
    AL139321
    Consensus CDS
    CCDS41887.1
    UniProtKB/TrEMBL
    H0Y4X7
    Related
    ENSP00000417539.1, ENST00000488958.5
    Conserved Domains (1) summary
    cl22851
    Location:6120
    PHD_SF; PHD finger superfamily
  3. NM_001419873.1NP_001406802.1  PHD finger protein 11 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL139321
    UniProtKB/TrEMBL
    H0Y4X7
  4. NM_001419874.1NP_001406803.1  PHD finger protein 11 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL139321
    UniProtKB/TrEMBL
    H0Y4X7
    Related
    ENSP00000350209.3, ENST00000357596.7
  5. NM_001419875.1NP_001406804.1  PHD finger protein 11 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL139321
    UniProtKB/TrEMBL
    H0Y4X7
  6. NM_001419876.1NP_001406805.1  PHD finger protein 11 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL139321
    UniProtKB/TrEMBL
    H0Y4X7

RNA

  1. NR_135322.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AK026228, AK293242, BX461254
  2. NR_135323.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL139321

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    49495953..49528976
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    48714592..48747507
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)