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TRIM17 tripartite motif containing 17 [ Homo sapiens (human) ]

Gene ID: 51127, updated on 11-Jun-2021

Summary

Official Symbol
TRIM17provided by HGNC
Official Full Name
tripartite motif containing 17provided by HGNC
Primary source
HGNC:HGNC:13430
See related
Ensembl:ENSG00000162931 MIM:606123
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RBCC; terf; RNF16
Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein is expressed almost exclusively in the testis, but its function is unknown. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 5.7), spleen (RPKM 1.3) and 11 other tissues See more
Orthologs
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Genomic context

See TRIM17 in Genome Data Viewer
Location:
1q42.13
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (228406877..228416882, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (228595636..228604562, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF Neighboring gene uncharacterized LOC101927401 Neighboring gene tripartite motif containing 11 Neighboring gene microRNA 6742 Neighboring gene H3.4 histone Neighboring gene ribosomal protein L23a pseudogene 15

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-macromolecule adaptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in autophagy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein autoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRIM17
Names
RING finger protein terf
RING-type E3 ubiquitin transferase TRIM17
ring finger protein 16
testis RING finger protein
tripartite motif-containing protein 17
NP_001020111.1
NP_001128327.1
NP_057186.1
XP_006711842.1
XP_011542511.1
XP_011542512.1
XP_011542513.1
XP_016856908.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024940.3NP_001020111.1  E3 ubiquitin-protein ligase TRIM17 isoform 1

    See identical proteins and their annotated locations for NP_001020111.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a segment in the 5' UTR, as compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AW770403, BC033788, DA270450
    Consensus CDS
    CCDS1571.1
    UniProtKB/Swiss-Prot
    Q9Y577
    UniProtKB/TrEMBL
    A0A024R3T1
    Related
    ENSP00000295033.3, ENST00000295033.7
    Conserved Domains (3) summary
    cd00021
    Location:97134
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd15812
    Location:296472
    SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)
    cd16595
    Location:1366
    RING-HC_TRIM17_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein TRIM17 and similar proteins
  2. NM_001134855.2NP_001128327.1  E3 ubiquitin-protein ligase TRIM17 isoform 3

    See identical proteins and their annotated locations for NP_001128327.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 3' coding region and UTR, compared to variant 1. The encoded protein (isoform 3) has a shorter and distinct C-terminus that lacks a SPRY domain, compared to isoform 1.
    Source sequence(s)
    AK308774, DC309740
    Consensus CDS
    CCDS44327.1
    UniProtKB/Swiss-Prot
    Q9Y577
    Related
    ENSP00000403312.2, ENST00000456946.6
    Conserved Domains (2) summary
    cd00021
    Location:97134
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cl17238
    Location:1665
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  3. NM_016102.4NP_057186.1  E3 ubiquitin-protein ligase TRIM17 isoform 1

    See identical proteins and their annotated locations for NP_057186.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AW770403, BC033788, DA270450, DB031719
    Consensus CDS
    CCDS1571.1
    UniProtKB/Swiss-Prot
    Q9Y577
    UniProtKB/TrEMBL
    A0A024R3T1
    Related
    ENSP00000355659.2, ENST00000366698.7
    Conserved Domains (3) summary
    cd00021
    Location:97134
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd15812
    Location:296472
    SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)
    cd16595
    Location:1366
    RING-HC_TRIM17_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein TRIM17 and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    228406877..228416882 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544210.3XP_011542512.1  E3 ubiquitin-protein ligase TRIM17 isoform X1

    See identical proteins and their annotated locations for XP_011542512.1

    UniProtKB/Swiss-Prot
    Q9Y577
    UniProtKB/TrEMBL
    A0A024R3T1
    Conserved Domains (3) summary
    cd00021
    Location:97134
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd15812
    Location:296472
    SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)
    cd16595
    Location:1366
    RING-HC_TRIM17_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein TRIM17 and similar proteins
  2. XM_011544211.3XP_011542513.1  E3 ubiquitin-protein ligase TRIM17 isoform X2

    See identical proteins and their annotated locations for XP_011542513.1

    Conserved Domains (3) summary
    cd00021
    Location:70107
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd15812
    Location:269445
    SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)
    cl17238
    Location:438
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  3. XM_006711779.3XP_006711842.1  E3 ubiquitin-protein ligase TRIM17 isoform X1

    See identical proteins and their annotated locations for XP_006711842.1

    UniProtKB/Swiss-Prot
    Q9Y577
    UniProtKB/TrEMBL
    A0A024R3T1
    Conserved Domains (3) summary
    cd00021
    Location:97134
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd15812
    Location:296472
    SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)
    cd16595
    Location:1366
    RING-HC_TRIM17_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein TRIM17 and similar proteins
  4. XM_011544209.3XP_011542511.1  E3 ubiquitin-protein ligase TRIM17 isoform X1

    See identical proteins and their annotated locations for XP_011542511.1

    UniProtKB/Swiss-Prot
    Q9Y577
    UniProtKB/TrEMBL
    A0A024R3T1
    Conserved Domains (3) summary
    cd00021
    Location:97134
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd15812
    Location:296472
    SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)
    cd16595
    Location:1366
    RING-HC_TRIM17_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein TRIM17 and similar proteins
  5. XM_017001419.1XP_016856908.1  E3 ubiquitin-protein ligase TRIM17 isoform X3

    UniProtKB/TrEMBL
    B3KP04
    Related
    ENSP00000430468.1, ENST00000479800.1
    Conserved Domains (2) summary
    cd00021
    Location:97134
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cl17238
    Location:1665
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RNA

  1. XR_949144.1 RNA Sequence

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654708.1 Reference GRCh38.p13 PATCHES

    Range
    1..8060 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001024941.2: Suppressed sequence

    Description
    NM_001024941.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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