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NAA20 N(alpha)-acetyltransferase 20, NatB catalytic subunit [ Homo sapiens (human) ]

Gene ID: 51126, updated on 5-Nov-2017
Official Symbol
NAA20provided by HGNC
Official Full Name
N(alpha)-acetyltransferase 20, NatB catalytic subunitprovided by HGNC
Primary source
HGNC:HGNC:15908
See related
Ensembl:ENSG00000173418 MIM:610833; Vega:OTTHUMG00000031998
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NAT3; NAT5; NAT3P; NAT5P; dJ1002M8.1
Summary
NAT5 is a component of N-acetyltransferase complex B (NatB). Human NatB performs cotranslational N(alpha)-terminal acetylation of methionine residues when they are followed by asparagine (Starheim et al., 2008 [PubMed 18570629]).[supplied by OMIM, Apr 2009]
Expression
Ubiquitous expression in esophagus (RPKM 49.8), testis (RPKM 35.7) and 25 other tissues See more
Orthologs
Location:
20p11.23
Exon count:
7
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 20 NC_000020.11 (20017290..20033629)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (19997934..20014273)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene cutaneous T-cell lymphoma-associated antigen 1 pseudogene Neighboring gene Ras and Rab interactor 2 Neighboring gene ribosomal protein L12 pseudogene 12 Neighboring gene uncharacterized LOC105372553 Neighboring gene crooked neck pre-mRNA splicing factor 1 Neighboring gene cilia and flagella associated protein 61 Neighboring gene uncharacterized LOC105372554

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
peptide alpha-N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
N-terminal peptidyl-methionine acetylation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
NatB complex IBA
Inferred from Biological aspect of Ancestor
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
intracellular IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
N-alpha-acetyltransferase 20
Names
N-acetyltransferase 3 homolog
N-acetyltransferase 5 (ARD1 homolog, S. cerevisiae)
N-acetyltransferase 5 (GCN5-related, putative)
N-acetyltransferase 5, ARD1 subunit (arrest-defective 1, S. cerevisiae, homolog)
N-terminal acetyltransferase B complex catalytic subunit NAA20
N-terminal acetyltransferase B complex catalytic subunit NAT5
N-terminal acetyltransferase complex ARD1 subunit
methionine N-acetyltransferase
natB catalytic subunit
natB complex subunit NAT5
NP_057184.1
NP_852668.1
NP_852669.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016100.4NP_057184.1  N-alpha-acetyltransferase 20 isoform a

    See identical proteins and their annotated locations for NP_057184.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    BC008446, BU680824, CA867744
    Consensus CDS
    CCDS13141.1
    UniProtKB/Swiss-Prot
    P61599
    Related
    ENSP00000335636.4, OTTHUMP00000030374, ENST00000334982.8, OTTHUMT00000078217
    Conserved Domains (1) summary
    COG0456
    Location:1156
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
  2. NM_181527.3NP_852668.1  N-alpha-acetyltransferase 20 isoform b

    See identical proteins and their annotated locations for NP_852668.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1, resulting in an isoform (b) which is shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AL035454, AL049538, BU680824
    Consensus CDS
    CCDS42854.1
    UniProtKB/TrEMBL
    A8MZB2
    Related
    ENSP00000381603.2, OTTHUMP00000205164, ENST00000398602.2, OTTHUMT00000334102
    Conserved Domains (2) summary
    COG0456
    Location:13144
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
    pfam00583
    Location:38116
    Acetyltransf_1; Acetyltransferase (GNAT) family
  3. NM_181528.3NP_852669.1  N-alpha-acetyltransferase 20 isoform c

    See identical proteins and their annotated locations for NP_852669.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon compared to variant 1, which causes a frameshift. The exon combination for the transcript is supported by full-length ESTs (BG548527.1 and CD641402.1). The resulting isoform (c) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    BC008446, BG548527, BU680824, CA867744
    Consensus CDS
    CCDS13142.1
    UniProtKB/Swiss-Prot
    P61599
    Related
    ENSP00000311027.4, OTTHUMP00000205165, ENST00000310450.8, OTTHUMT00000127786
    Conserved Domains (2) summary
    COG0456
    Location:1102
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
    pfam00583
    Location:5098
    Acetyltransf_1; Acetyltransferase (GNAT) family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p7 Primary Assembly

    Range
    20017290..20033629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 Alternate CHM1_1.1

    Range
    19998308..20014651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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