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ZNF706 zinc finger protein 706 [ Homo sapiens (human) ]

Gene ID: 51123, updated on 5-Aug-2022

Summary

Official Symbol
ZNF706provided by HGNC
Official Full Name
zinc finger protein 706provided by HGNC
Primary source
HGNC:HGNC:24992
See related
Ensembl:ENSG00000120963 MIM:619526; AllianceGenome:HGNC:24992
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSPC038; PNAS-106; PNAS-113
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in negative regulation of stem cell population maintenance and negative regulation of transcription, DNA-templated. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 17.8), skin (RPKM 13.6) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF706 in Genome Data Viewer
Location:
8q22.3
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (101197052..101206222, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (102322770..102331941, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (102209280..102218450, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 1163 Neighboring gene ZNF706 neighboring transcript 1 Neighboring gene uncharacterized LOC107984005 Neighboring gene Sharpr-MPRA regulatory region 4487 Neighboring gene myeloid leukemia factor 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of stem cell population maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042510.2NP_001035975.1  zinc finger protein 706

    See identical proteins and their annotated locations for NP_001035975.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein. Variants 1, 3, 4 and 5 encode the same protein.
    Source sequence(s)
    AP001330, AP003469
    Consensus CDS
    CCDS6291.1
    UniProtKB/Swiss-Prot
    A8K362, Q9Y5V0
    Related
    ENSP00000428985.1, ENST00000519882.5
    Conserved Domains (1) summary
    pfam18658
    Location:4165
    zf-C2H2_12; Zinc-finger C2H2-type
  2. NM_001267708.2NP_001254637.1  zinc finger protein 706

    See identical proteins and their annotated locations for NP_001254637.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 3, 4 and 5 encode the same protein.
    Source sequence(s)
    AP001330, AP003469
    Consensus CDS
    CCDS6291.1
    UniProtKB/Swiss-Prot
    A8K362, Q9Y5V0
    Related
    ENSP00000430165.1, ENST00000521272.5
    Conserved Domains (1) summary
    pfam18658
    Location:4165
    zf-C2H2_12; Zinc-finger C2H2-type
  3. NM_001267709.2NP_001254638.1  zinc finger protein 706

    See identical proteins and their annotated locations for NP_001254638.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 3, 4 and 5 encode the same protein.
    Source sequence(s)
    AP001330, AP003469
    Consensus CDS
    CCDS6291.1
    UniProtKB/Swiss-Prot
    A8K362, Q9Y5V0
    Related
    ENSP00000428696.1, ENST00000518336.5
    Conserved Domains (1) summary
    pfam18658
    Location:4165
    zf-C2H2_12; Zinc-finger C2H2-type
  4. NM_016096.5NP_057180.1  zinc finger protein 706

    See identical proteins and their annotated locations for NP_057180.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 3, 4 and 5 encode the same protein.
    Source sequence(s)
    AP001330, AP003469
    Consensus CDS
    CCDS6291.1
    UniProtKB/Swiss-Prot
    A8K362, Q9Y5V0
    Related
    ENSP00000311768.4, ENST00000311212.9
    Conserved Domains (1) summary
    pfam18658
    Location:4165
    zf-C2H2_12; Zinc-finger C2H2-type

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    101197052..101206222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421844.1XP_047277800.1  zinc finger protein 706 isoform X1

    UniProtKB/Swiss-Prot
    A8K362
    Related
    ENSP00000428227.1, ENST00000517844.5
  2. XM_047421843.1XP_047277799.1  zinc finger protein 706 isoform X1

    UniProtKB/Swiss-Prot
    A8K362

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    102322770..102331941 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)