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ZNF706 zinc finger protein 706 [ Homo sapiens (human) ]

Gene ID: 51123, updated on 1-Jun-2020

Summary

Official Symbol
ZNF706provided by HGNC
Official Full Name
zinc finger protein 706provided by HGNC
Primary source
HGNC:HGNC:24992
See related
Ensembl:ENSG00000120963
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSPC038; PNAS-106; PNAS-113
Expression
Ubiquitous expression in brain (RPKM 17.8), skin (RPKM 13.6) and 25 other tissues See more
Orthologs

Genomic context

See ZNF706 in Genome Data Viewer
Location:
8q22.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (101197038..101206470, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (102209266..102218292, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 1163 Neighboring gene ZNF706 neighboring transcript 1 Neighboring gene uncharacterized LOC107984005 Neighboring gene myeloid leukemia factor 2 pseudogene Neighboring gene long intergenic non-protein coding RNA 2844

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of stem cell population maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042510.1NP_001035975.1  zinc finger protein 706

    See identical proteins and their annotated locations for NP_001035975.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein. Variants 1, 3, 4 and 5 encode the same protein.
    Source sequence(s)
    AP003469, AV721205, BI755311, DB549532
    Consensus CDS
    CCDS6291.1
    UniProtKB/Swiss-Prot
    Q9Y5V0
    Related
    ENSP00000428985.1, ENST00000519882.5
    Conserved Domains (1) summary
    pfam04419
    Location:137
    4F5; 4F5 protein family
  2. NM_001267708.1NP_001254637.1  zinc finger protein 706

    See identical proteins and their annotated locations for NP_001254637.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 3, 4 and 5 encode the same protein.
    Source sequence(s)
    AP003469, AV721205, BI669563, DB549532
    Consensus CDS
    CCDS6291.1
    UniProtKB/Swiss-Prot
    Q9Y5V0
    Related
    ENSP00000430165.1, ENST00000521272.5
    Conserved Domains (1) summary
    pfam04419
    Location:137
    4F5; 4F5 protein family
  3. NM_001267709.1NP_001254638.1  zinc finger protein 706

    See identical proteins and their annotated locations for NP_001254638.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 3, 4 and 5 encode the same protein.
    Source sequence(s)
    AP003469, DB231109, DB549532
    Consensus CDS
    CCDS6291.1
    UniProtKB/Swiss-Prot
    Q9Y5V0
    Related
    ENSP00000428696.1, ENST00000518336.5
    Conserved Domains (1) summary
    pfam04419
    Location:137
    4F5; 4F5 protein family
  4. NM_016096.5NP_057180.1  zinc finger protein 706

    See identical proteins and their annotated locations for NP_057180.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 3, 4 and 5 encode the same protein.
    Source sequence(s)
    AP001330, AP003469
    Consensus CDS
    CCDS6291.1
    UniProtKB/Swiss-Prot
    Q9Y5V0
    Related
    ENSP00000311768.4, ENST00000311212.9
    Conserved Domains (1) summary
    pfam04419
    Location:137
    4F5; 4F5 protein family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    101197038..101206470 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447173.1XP_024302941.1  zinc finger protein 706 isoform X1

    Related
    ENSP00000427761.1, ENST00000520984.5
  2. XM_024447172.1XP_024302940.1  zinc finger protein 706 isoform X1

    Related
    ENSP00000430823.1, ENST00000520347.5
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