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ZNF706 zinc finger protein 706 [ Homo sapiens (human) ]

Gene ID: 51123, updated on 9-Jun-2025
Official Symbol
ZNF706provided by HGNC
Official Full Name
zinc finger protein 706provided by HGNC
Primary source
HGNC:HGNC:24992
See related
Ensembl:ENSG00000120963 MIM:619526; AllianceGenome:HGNC:24992
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSPC038; PNAS-106; PNAS-113
Summary
Predicted to enable zinc ion binding activity. Predicted to be involved in negative regulation of DNA-templated transcription and negative regulation of stem cell population maintenance. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Ubiquitous expression in brain (RPKM 17.8), skin (RPKM 13.6) and 25 other tissues See more
Orthologs
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See ZNF706 in Genome Data Viewer
Location:
8q22.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (101197052..101206222, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (102322770..102331941, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (102209280..102218450, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375676 Neighboring gene NFE2L2 motif-containing MPRA enhancer 220/221 Neighboring gene Sharpr-MPRA regulatory region 12327 Neighboring gene Sharpr-MPRA regulatory region 12099 Neighboring gene Sharpr-MPRA regulatory region 1163 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27728 Neighboring gene ZNF706 neighboring transcript 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19431 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19432 Neighboring gene uncharacterized LOC107984005 Neighboring gene Sharpr-MPRA regulatory region 4487 Neighboring gene myeloid leukemia factor 2 pseudogene Neighboring gene MPRA-validated peak7131 silencer Neighboring gene long intergenic non-protein coding RNA 2844

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Protein G-quadruplex interactions and their effects on phase transitions and protein aggregation. Sahoo BR, et al. Nucleic Acids Res, 2024 May 8. PMID 38572746, Free PMC Article
  2. The molecular and functional interaction between ICln and HSPC038 proteins modulates the regulation of cell volume. Dossena S, et al. J Biol Chem, 2011 Nov 25. PMID 21917931, Free PMC Article
  3. A novel MYC-ZNF706-SLC7A11 regulatory circuit contributes to cancer progression and redox balance in human hepatocellular carcinoma. Chu J, et al. Cell Death Differ, 2024 Oct. PMID 38862581, Free PMC Article
  4. Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. McClay JL, et al. Neuropsychopharmacology, 2011 Feb. PMID 21107309, Free PMC Article
  5. Splicing Regulator p54(nrb) /Non-POU Domain-Containing Octamer-Binding Protein Enhances Carcinogenesis Through Oncogenic Isoform Switch of MYC Box-Dependent Interacting Protein 1 in Hepatocellular Carcinoma. Hu Z, et al. Hepatology, 2020 Aug. PMID 31815296

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A novel MYC-ZNF706-SLC7A11 regulatory circuit contributes to cancer progression and redox balance in human hepatocellular carcinoma.
    Title: A novel MYC-ZNF706-SLC7A11 regulatory circuit contributes to cancer progression and redox balance in human hepatocellular carcinoma.
  2. Protein G-quadruplex interactions and their effects on phase transitions and protein aggregation.
    Title: Protein G-quadruplex interactions and their effects on phase transitions and protein aggregation.
  3. functional interaction between ICln and HSPC038
    Title: The molecular and functional interaction between ICln and HSPC038 proteins modulates the regulation of cell volume.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of stem cell population maintenance ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
zinc finger protein 706

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042510.2 → NP_001035975.1  zinc finger protein 706

    See identical proteins and their annotated locations for NP_001035975.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein. Variants 1, 3, 4 and 5 encode the same protein.
    Source sequence(s)
    AP001330, AP003469
    Consensus CDS
    CCDS6291.1
    UniProtKB/Swiss-Prot
    A8K362, Q9Y5V0
    UniProtKB/TrEMBL
    Q9HB72
    Related
    ENSP00000428985.1, ENST00000519882.5
    Conserved Domains (1) summary
    pfam18658
    Location:41 → 65
    zf-C2H2_12; Zinc-finger C2H2-type

  2. NM_001267708.2 → NP_001254637.1  zinc finger protein 706

    See identical proteins and their annotated locations for NP_001254637.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 3, 4 and 5 encode the same protein.
    Source sequence(s)
    AP001330, AP003469
    Consensus CDS
    CCDS6291.1
    UniProtKB/Swiss-Prot
    A8K362, Q9Y5V0
    UniProtKB/TrEMBL
    Q9HB72
    Related
    ENSP00000430165.1, ENST00000521272.5
    Conserved Domains (1) summary
    pfam18658
    Location:41 → 65
    zf-C2H2_12; Zinc-finger C2H2-type

  3. NM_001267709.2 → NP_001254638.1  zinc finger protein 706

    See identical proteins and their annotated locations for NP_001254638.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 3, 4 and 5 encode the same protein.
    Source sequence(s)
    AP001330, AP003469
    Consensus CDS
    CCDS6291.1
    UniProtKB/Swiss-Prot
    A8K362, Q9Y5V0
    UniProtKB/TrEMBL
    Q9HB72
    Related
    ENSP00000428696.1, ENST00000518336.5
    Conserved Domains (1) summary
    pfam18658
    Location:41 → 65
    zf-C2H2_12; Zinc-finger C2H2-type

  4. NM_016096.5 → NP_057180.1  zinc finger protein 706

    See identical proteins and their annotated locations for NP_057180.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 3, 4 and 5 encode the same protein.
    Source sequence(s)
    AP001330, AP003469
    Consensus CDS
    CCDS6291.1
    UniProtKB/Swiss-Prot
    A8K362, Q9Y5V0
    UniProtKB/TrEMBL
    Q9HB72
    Related
    ENSP00000311768.4, ENST00000311212.9
    Conserved Domains (1) summary
    pfam18658
    Location:41 → 65
    zf-C2H2_12; Zinc-finger C2H2-type

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    101197052..101206222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421844.1 → XP_047277800.1  zinc finger protein 706 isoform X1

    UniProtKB/Swiss-Prot
    A8K362, Q9Y5V0
    UniProtKB/TrEMBL
    Q9HB72
    Related
    ENSP00000428227.1, ENST00000517844.5

  2. XM_047421843.1 → XP_047277799.1  zinc finger protein 706 isoform X1

    UniProtKB/Swiss-Prot
    A8K362, Q9Y5V0
    UniProtKB/TrEMBL
    Q9HB72

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    102322770..102331941 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360612.1 → XP_054216587.1  zinc finger protein 706 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y5V0.1 GenPept UniProtKB/Swiss-Prot:Q9Y5V0

Gene LinkOut

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