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NFATC1 nuclear factor of activated T cells 1 [ Bos taurus (domestic cattle) ]

Gene ID: 511224, updated on 30-Jan-2025
Official Symbol
NFATC1provided by VGNC
Official Full Name
nuclear factor of activated T cells 1provided by VGNC
Primary source
VGNC:VGNC:32030
See related
BGD:BT20788; EnsemblRapid:ENSBTAG00070021371
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
NFAT; NF-ATc; NF-ATc1
Orthologs
human mouse all
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See NFATC1 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 24 NC_037351.1 (779625..867300, complement)

Chromosome 24 - NC_037351.1Genomic Context describing neighboring genes Neighboring gene tigger transposable element-derived protein 1 Neighboring gene CTD phosphatase subunit 1 Neighboring gene ATPase phospholipid transporting 9B (putative) Neighboring gene uncharacterized LOC132343745 Neighboring gene U6 spliceosomal RNA

Genomic Sequence:
NC_037351.1 Chromosome 24 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. A fluorescence-based assay to monitor transcriptional activity of NFAT in living cells. Rinne A, et al. J Physiol, 2010 Sep 1. PMID 20624790, Free PMC Article
  2. Regulation of nuclear factor of activated T cells (NFAT) in vascular endothelial cells. Rinne A, et al. J Mol Cell Cardiol, 2009 Sep. PMID 19540841, Free PMC Article
  3. NF-AT components define a family of transcription factors targeted in T-cell activation. Northrop JP, et al. Nature, 1994 Jun 9. PMID 8202141
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transcription factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcineurin-NFAT signaling cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytokine production IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
nuclear factor of activated T-cells, cytoplasmic 1
Names
NFAT transcription complex cytosolic component
NFATc
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166615.2 → NP_001160087.1  nuclear factor of activated T-cells, cytoplasmic 1

    See identical proteins and their annotated locations for NP_001160087.1

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000024
    UniProtKB/TrEMBL
    A0AAA9SHK0
    Related
    ENSBTAP00070028806.1, ENSBTAT00070048253.1
    Conserved Domains (2) summary
    cd07881
    Location:395 → 569
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cl15674
    Location:574 → 674
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037351.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    779625..867300 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024984233.2 → XP_024840001.1  nuclear factor of activated T-cells, cytoplasmic 1 isoform X2

    UniProtKB/Swiss-Prot
    P98201
    UniProtKB/TrEMBL
    A0A3Q1M5J8
    Related
    ENSBTAP00070028843.1, ENSBTAT00070048314.1
    Conserved Domains (2) summary
    cd07881
    Location:407 → 581
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cl15674
    Location:586 → 686
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

  2. XM_024984232.2 → XP_024840000.1  nuclear factor of activated T-cells, cytoplasmic 1 isoform X1

    UniProtKB/TrEMBL
    A0AAA9SHK0
    Related
    ENSBTAP00070028825.1, ENSBTAT00070048288.1
    Conserved Domains (2) summary
    cd07881
    Location:407 → 581
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cl15674
    Location:586 → 686
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

  3. XM_005223925.5 → XP_005223982.1  nuclear factor of activated T-cells, cytoplasmic 1 isoform X3

    UniProtKB/Swiss-Prot
    P98201
    UniProtKB/TrEMBL
    A0A3Q1LGN8
    Related
    ENSBTAP00070028835.1, ENSBTAT00070048302.1
    Conserved Domains (2) summary
    cd07881
    Location:395 → 569
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cl15674
    Location:574 → 674
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

  4. XM_059880799.1 → XP_059736782.1  nuclear factor of activated T-cells, cytoplasmic 1 isoform X4

    UniProtKB/Swiss-Prot
    P98201
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P98201.2 GenPept UniProtKB/Swiss-Prot:P98201

Gene LinkOut

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