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RMDN1 regulator of microtubule dynamics 1 [ Homo sapiens (human) ]

Gene ID: 51115, updated on 8-Aug-2021

Summary

Official Symbol
RMDN1provided by HGNC
Official Full Name
regulator of microtubule dynamics 1provided by HGNC
Primary source
HGNC:HGNC:24285
See related
Ensembl:ENSG00000176623 MIM:611871
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RMD1; RMD-1; CGI-90; FAM82B
Expression
Ubiquitous expression in thyroid (RPKM 10.5), fat (RPKM 10.4) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See RMDN1 in Genome Data Viewer
Location:
8q21.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (86467055..86514357, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (87484578..87526586, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene HNF4 motif-containing MPRA enhancer 29 Neighboring gene WWP1 antisense RNA 1 Neighboring gene WW domain containing E3 ubiquitin protein ligase 1 Neighboring gene N-terminal asparagine amidase pseudogene 2 Neighboring gene solute carrier family 2 member 3 pseudogene 4 Neighboring gene copine 3 Neighboring gene cyclic nucleotide gated channel subunit beta 3 Neighboring gene myo-inositol oxygenase pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20665

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mitotic spindle organization ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in mitotic spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitotic spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in spindle microtubule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
regulator of microtubule dynamics protein 1
Names
family with sequence similarity 82, member B
microtubule-associated protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286707.2NP_001273636.1  regulator of microtubule dynamics protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks and in-frame exon and uses and alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC103817, AK297896, BP234465, BX640636
    Consensus CDS
    CCDS69509.1
    UniProtKB/Swiss-Prot
    Q96DB5
    UniProtKB/TrEMBL
    Q6N086
    Related
    ENSP00000428661.1, ENST00000519966.5
  2. NM_001286719.2NP_001273648.1  regulator of microtubule dynamics protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001273648.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC103817, AK303122, BX640636
    Consensus CDS
    CCDS69510.1
    UniProtKB/Swiss-Prot
    Q96DB5
    UniProtKB/TrEMBL
    Q6N086
    Related
    ENSP00000409661.2, ENST00000430676.6
    Conserved Domains (1) summary
    sd00006
    Location:140169
    TPR; TPR repeat [structural motif]
  3. NM_001317807.2NP_001304736.1  regulator of microtubule dynamics protein 1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' and 3' UTRs, lacks a portion of the 5' coding region, uses a downstream translation start site, and uses two alternate splice sites in the 3' coding region, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC103817, AF151848, AL561197, BU932433, BX640636
    Consensus CDS
    CCDS83305.1
    UniProtKB/Swiss-Prot
    Q96DB5
    UniProtKB/TrEMBL
    E5RH53, Q6N086
    Related
    ENSP00000429899.1, ENST00000523911.5
    Conserved Domains (1) summary
    sd00006
    Location:116156
    TPR; TPR repeat [structural motif]
  4. NM_016033.3NP_057117.2  regulator of microtubule dynamics protein 1 isoform 1

    See identical proteins and their annotated locations for NP_057117.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC103817, AF151848, BP199284, BP234465
    Consensus CDS
    CCDS34918.1
    UniProtKB/Swiss-Prot
    Q96DB5
    Related
    ENSP00000385927.3, ENST00000406452.8
    Conserved Domains (1) summary
    sd00006
    Location:164199
    TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    86467055..86514357 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517090.3XP_011515392.1  regulator of microtubule dynamics protein 1 isoform X1

    Conserved Domains (2) summary
    COG0457
    Location:70303
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:178213
    TPR; TPR repeat [structural motif]
  2. XM_017013518.2XP_016869007.1  regulator of microtubule dynamics protein 1 isoform X4

  3. XM_011517095.2XP_011515397.1  regulator of microtubule dynamics protein 1 isoform X10

    Conserved Domains (1) summary
    sd00006
    Location:178213
    TPR; TPR repeat [structural motif]
  4. XM_005250948.3XP_005251005.1  regulator of microtubule dynamics protein 1 isoform X7

    See identical proteins and their annotated locations for XP_005251005.1

    Conserved Domains (1) summary
    sd00006
    Location:120155
    TPR; TPR repeat [structural motif]
  5. XM_011517092.2XP_011515394.1  regulator of microtubule dynamics protein 1 isoform X5

    Conserved Domains (2) summary
    COG0457
    Location:96270
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:154183
    TPR; TPR repeat [structural motif]
  6. XM_011517091.2XP_011515393.1  regulator of microtubule dynamics protein 1 isoform X2

    Conserved Domains (2) summary
    sd00006
    Location:174214
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:159216
    TPR_11; TPR repeat
  7. XM_005250947.3XP_005251004.1  regulator of microtubule dynamics protein 1 isoform X6

    Conserved Domains (2) summary
    COG0457
    Location:82256
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:140169
    TPR; TPR repeat [structural motif]
  8. XM_005250944.3XP_005251001.1  regulator of microtubule dynamics protein 1 isoform X3

    Conserved Domains (2) summary
    COG0457
    Location:56289
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:164199
    TPR; TPR repeat [structural motif]
  9. XM_006716573.4XP_006716636.1  regulator of microtubule dynamics protein 1 isoform X7

    See identical proteins and their annotated locations for XP_006716636.1

    Conserved Domains (1) summary
    sd00006
    Location:120155
    TPR; TPR repeat [structural motif]
  10. XM_017013526.1XP_016869015.1  regulator of microtubule dynamics protein 1 isoform X21

    Conserved Domains (1) summary
    sd00006
    Location:116156
    TPR; TPR repeat [structural motif]
  11. XM_017013524.1XP_016869013.1  regulator of microtubule dynamics protein 1 isoform X19

    Conserved Domains (1) summary
    sd00006
    Location:120155
    TPR; TPR repeat [structural motif]
  12. XM_017013528.1XP_016869017.1  regulator of microtubule dynamics protein 1 isoform X22

  13. XM_011517098.2XP_011515400.1  regulator of microtubule dynamics protein 1 isoform X17

  14. XM_011517097.2XP_011515399.1  regulator of microtubule dynamics protein 1 isoform X15

    Conserved Domains (1) summary
    sd00006
    Location:154183
    TPR; TPR repeat [structural motif]
  15. XM_017013519.1XP_016869008.1  regulator of microtubule dynamics protein 1 isoform X12

  16. XM_011517096.2XP_011515398.1  regulator of microtubule dynamics protein 1 isoform X11

    Conserved Domains (1) summary
    sd00006
    Location:174214
    TPR; TPR repeat [structural motif]
  17. XM_011517094.2XP_011515396.1  regulator of microtubule dynamics protein 1 isoform X9

    Conserved Domains (1) summary
    sd00006
    Location:178213
    TPR; TPR repeat [structural motif]
  18. XM_011517093.2XP_011515395.1  regulator of microtubule dynamics protein 1 isoform X8

    Conserved Domains (1) summary
    sd00006
    Location:178213
    TPR; TPR repeat [structural motif]
  19. XM_017013521.1XP_016869010.1  regulator of microtubule dynamics protein 1 isoform X14

  20. XM_017013520.1XP_016869009.1  regulator of microtubule dynamics protein 1 isoform X13

  21. XM_017013527.2XP_016869016.1  regulator of microtubule dynamics protein 1 isoform X22

  22. XM_017013522.1XP_016869011.1  regulator of microtubule dynamics protein 1 isoform X16

  23. XM_017013523.1XP_016869012.1  regulator of microtubule dynamics protein 1 isoform X18

RNA

  1. XR_928336.3 RNA Sequence

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