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TRAPPC12 trafficking protein particle complex 12 [ Homo sapiens (human) ]

Gene ID: 51112, updated on 20-Dec-2019

Summary

Official Symbol
TRAPPC12provided by HGNC
Official Full Name
trafficking protein particle complex 12provided by HGNC
Primary source
HGNC:HGNC:24284
See related
Ensembl:ENSG00000171853 MIM:614139
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PEBAS; TTC15; CGI-87; TTC-15
Expression
Ubiquitous expression in testis (RPKM 6.2), brain (RPKM 2.7) and 25 other tissues See more
Orthologs

Genomic context

See TRAPPC12 in Genome Data Viewer
Location:
2p25.3
Exon count:
20
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (3379245..3479571)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (3383446..3483342)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene EARP complex and GARP complex interacting protein 1 Neighboring gene Sharpr-MPRA regulatory region 3808 Neighboring gene VISTA enhancer hs1385 Neighboring gene uncharacterized LOC112268321 Neighboring gene acireductone dioxygenase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
ENCEPHALOPATHY, PROGRESSIVE, EARLY-ONSET, WITH BRAIN ATROPHY AND SPASTICITY
MedGen: C4540059 OMIM: 617669 GeneReviews: Not available
not available

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of trafficking protein particle complex 12 (TRAPPC12) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36862, FLJ44560

Gene Ontology Provided by GOA

Function Evidence Code Pubs
endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Golgi organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
metaphase plate congression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein localization to kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein complex oligomerization IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
regulation of kinetochore assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
TRAPP complex IDA
Inferred from Direct Assay
more info
PubMed 
cell IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
colocalizes_with endoplasmic reticulum-Golgi intermediate compartment IMP
Inferred from Mutant Phenotype
more info
PubMed 
kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with perinuclear region of cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
trafficking protein particle complex subunit 12
Names
TPR repeat protein 15
tetratricopeptide repeat domain 15
tetratricopeptide repeat protein 15
trafficking of membranes and mitosis

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321102.1NP_001308031.1  trafficking protein particle complex subunit 12

    Status: VALIDATED

    Source sequence(s)
    AC114810, AI270453, AK098327
    Consensus CDS
    CCDS1652.1
    UniProtKB/Swiss-Prot
    Q8WVT3
    Related
    ENSP00000371544.2, ENST00000382110.6
    Conserved Domains (4) summary
    sd00006
    Location:546573
    TPR; TPR repeat [structural motif]
    pfam11035
    Location:61134
    SnAPC_2_like; Small nuclear RNA activating complex subunit 2, SNAP190 Myb
    pfam13414
    Location:622685
    TPR_11; TPR repeat
    pfam13424
    Location:581652
    TPR_12; Tetratricopeptide repeat
  2. NM_016030.6NP_057114.5  trafficking protein particle complex subunit 12

    See identical proteins and their annotated locations for NP_057114.5

    Status: VALIDATED

    Source sequence(s)
    AF151845, BC014164, BC017475, DA031172
    Consensus CDS
    CCDS1652.1
    UniProtKB/Swiss-Prot
    Q8WVT3
    Related
    ENSP00000324318.5, ENST00000324266.10
    Conserved Domains (4) summary
    sd00006
    Location:546573
    TPR; TPR repeat [structural motif]
    pfam11035
    Location:61134
    SnAPC_2_like; Small nuclear RNA activating complex subunit 2, SNAP190 Myb
    pfam13414
    Location:622685
    TPR_11; TPR repeat
    pfam13424
    Location:581652
    TPR_12; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    3379245..3479571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510350.2XP_011508652.1  trafficking protein particle complex subunit 12 isoform X1

    Conserved Domains (4) summary
    sd00006
    Location:508535
    TPR; TPR repeat [structural motif]
    pfam11035
    Location:61134
    SnAPC_2_like; Small nuclear RNA activating complex subunit 2, SNAP190 Myb
    pfam13414
    Location:584647
    TPR_11; TPR repeat
    pfam13424
    Location:543614
    TPR_12; Tetratricopeptide repeat
  2. XM_017004257.1XP_016859746.1  trafficking protein particle complex subunit 12 isoform X2

  3. XM_011510352.2XP_011508654.1  trafficking protein particle complex subunit 12 isoform X3

    Conserved Domains (1) summary
    pfam11035
    Location:61134
    SnAPC_2_like; Small nuclear RNA activating complex subunit 2, SNAP190 Myb
  4. XM_011510353.2XP_011508655.1  trafficking protein particle complex subunit 12 isoform X4

    Conserved Domains (1) summary
    pfam11035
    Location:61134
    SnAPC_2_like; Small nuclear RNA activating complex subunit 2, SNAP190 Myb
  5. XM_011510354.2XP_011508656.1  trafficking protein particle complex subunit 12 isoform X5

    Conserved Domains (1) summary
    pfam11035
    Location:61134
    SnAPC_2_like; Small nuclear RNA activating complex subunit 2, SNAP190 Myb
  6. XM_011510356.1XP_011508658.1  trafficking protein particle complex subunit 12 isoform X7

    See identical proteins and their annotated locations for XP_011508658.1

    UniProtKB/TrEMBL
    A0A0J9YXQ9
    Conserved Domains (3) summary
    sd00006
    Location:190217
    TPR; TPR repeat [structural motif]
    cl26002
    Location:199379
    TPR_11; TPR repeat
    cl26250
    Location:193252
    TPR_6; Tetratricopeptide repeat
  7. XM_011510355.2XP_011508657.1  trafficking protein particle complex subunit 12 isoform X6

    Conserved Domains (4) summary
    TIGR02795
    Location:234293
    tol_pal_ybgF; tol-pal system protein YbgF
    sd00006
    Location:231258
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:307370
    TPR_11; TPR repeat
    pfam13424
    Location:266337
    TPR_12; Tetratricopeptide repeat

RNA

  1. XR_426956.3 RNA Sequence

  2. XR_001738762.1 RNA Sequence

  3. XR_001738761.1 RNA Sequence

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187522.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    9876..89041
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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