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METTL9 methyltransferase like 9 [ Homo sapiens (human) ]

Gene ID: 51108, updated on 7-Jun-2020

Summary

Official Symbol
METTL9provided by HGNC
Official Full Name
methyltransferase like 9provided by HGNC
Primary source
HGNC:HGNC:24586
See related
Ensembl:ENSG00000197006 MIM:609388
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DREV; PAP1; DREV1; CGI-81
Expression
Ubiquitous expression in kidney (RPKM 38.8), adrenal (RPKM 37.6) and 25 other tissues See more
Orthologs

Genomic context

See METTL9 in Genome Data Viewer
Location:
16p12.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (21597221..21657473)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (21608543..21668792)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 7 member 5 pseudogene 2 Neighboring gene carbonic anhydrase 5A pseudogene Neighboring gene uncharacterized LOC101927814 Neighboring gene RNA, U6 small nuclear 1005, pseudogene Neighboring gene RNA, U6 small nuclear 196, pseudogene Neighboring gene immunoglobulin superfamily member 6 Neighboring gene otoancorin Neighboring gene uncharacterized LOC105371126 Neighboring gene RRN3 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21912

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
methyltransferase-like protein 9
Names
CTB-31N19.3
DORA reverse strand protein 1
p53 activated protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077180.2NP_001070648.1  methyltransferase-like protein 9 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001070648.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AI096621, AJ278578, BC000195, CF146931
    Consensus CDS
    CCDS45440.1
    UniProtKB/Swiss-Prot
    Q9H1A3
    Related
    ENSP00000379335.4, ENST00000396014.8
    Conserved Domains (1) summary
    pfam05219
    Location:56316
    DREV; DREV methyltransferase
  2. NM_001288659.1NP_001275588.1  methyltransferase-like protein 9 isoform 3

    See identical proteins and their annotated locations for NP_001275588.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC005632, AI096621, BC000195, BG183771
    UniProtKB/Swiss-Prot
    Q9H1A3
    Related
    ENSP00000454733.1, ENST00000567404.5
    Conserved Domains (1) summary
    pfam05219
    Location:16277
    DREV; DREV methyltransferase
  3. NM_001288660.1NP_001275589.1  methyltransferase-like protein 9 isoform 4

    See identical proteins and their annotated locations for NP_001275589.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, uses an alternate in-frame splice site in the 3' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC005632, AI096621, AJ278578, BC000195, BG183771
    UniProtKB/Swiss-Prot
    Q9H1A3
    Conserved Domains (1) summary
    pfam05219
    Location:16276
    DREV; DREV methyltransferase
  4. NM_016025.5NP_057109.3  methyltransferase-like protein 9 isoform 1 precursor

    See identical proteins and their annotated locations for NP_057109.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC000195, CF146931
    Consensus CDS
    CCDS10598.2
    UniProtKB/Swiss-Prot
    Q9H1A3
    Related
    ENSP00000350874.3, ENST00000358154.8
    Conserved Domains (1) summary
    pfam05219
    Location:56317
    DREV; DREV methyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    21597221..21657473
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450293.1XP_024306061.1  methyltransferase-like protein 9 isoform X2

    Conserved Domains (1) summary
    cl17173
    Location:1191
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. XM_017023269.1XP_016878758.1  methyltransferase-like protein 9 isoform X1

    Conserved Domains (1) summary
    cl17173
    Location:1192
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_017852933.1 Reference GRCh38.p13 PATCHES

    Range
    1447355..1507596 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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