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PHF20L1 PHD finger protein 20 like 1 [ Homo sapiens (human) ]

Gene ID: 51105, updated on 1-Jun-2020

Summary

Official Symbol
PHF20L1provided by HGNC
Official Full Name
PHD finger protein 20 like 1provided by HGNC
Primary source
HGNC:HGNC:24280
See related
Ensembl:ENSG00000129292
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
URLC1; CGI-72; TDRD20B
Expression
Ubiquitous expression in thyroid (RPKM 8.3), testis (RPKM 4.7) and 25 other tissues See more
Orthologs

Genomic context

See PHF20L1 in Genome Data Viewer
Location:
8q24.22
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (132775358..132848807)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (133787604..133861052)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene Helicobacter pylori responsive 1 Neighboring gene leucine rich repeat containing 6 Neighboring gene uncharacterized LOC105375767 Neighboring gene transmembrane protein 71 Neighboring gene thyroglobulin Neighboring gene uncharacterized LOC105375768 Neighboring gene ribosomal protein L21 pseudogene 78

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC64923

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
PHD finger protein 20-like protein 1
Names
tudor domain containing 20B
tudor domain-containing protein PHF20L1
up-regulated in lung cancer 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277196.2NP_001264125.1  PHD finger protein 20-like protein 1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1. Variants 4 and 5 encode the same isoform (4).
    Source sequence(s)
    AF228727, AF230666, BC144654, DB498348
    Consensus CDS
    CCDS75791.1
    UniProtKB/TrEMBL
    A0A0A0MQS0
    Conserved Domains (5) summary
    cd04508
    Location:90135
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd15633
    Location:657702
    PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)
    pfam12618
    Location:184291
    DUF3776; Protein of unknown function (DUF3776)
    pfam16660
    Location:292388
    PHD20L1_u1; PHD finger protein 20-like protein 1
    cl17705
    Location:368
    MBT; mbt repeat
  2. NM_001362971.1NP_001349900.1  PHD finger protein 20-like protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AF228727, AF230666, BC144654, DB498348
    Consensus CDS
    CCDS75791.1
    Related
    ENSP00000220847.8, ENST00000220847.8
    Conserved Domains (5) summary
    cd04508
    Location:90135
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd15633
    Location:657702
    PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)
    pfam12618
    Location:184291
    DUF3776; Protein of unknown function (DUF3776)
    pfam16660
    Location:292388
    PHD20L1_u1; PHD finger protein 20-like protein 1
    cl17705
    Location:368
    MBT; mbt repeat
  3. NM_016018.5NP_057102.4  PHD finger protein 20-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_057102.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
    Source sequence(s)
    AF230666, AK057961, BC002822, DA196349, DB498348
    Consensus CDS
    CCDS6367.2
    UniProtKB/Swiss-Prot
    A8MW92
    Related
    ENSP00000378784.2, ENST00000395386.6
    Conserved Domains (5) summary
    cd04508
    Location:90135
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd15633
    Location:683728
    PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)
    pfam12618
    Location:210317
    DUF3776; Protein of unknown function (DUF3776)
    pfam16660
    Location:318383
    PHD20L1_u1; PHD finger protein 20-like protein 1
    cl17705
    Location:368
    MBT; mbt repeat
  4. NM_198513.1NP_940915.1  PHD finger protein 20-like protein 1 isoform 3

    See identical proteins and their annotated locations for NP_940915.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences, compared to variant 1. The resulting protein (isoform 3) has a shorter and distinct C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AI913146, AK023711, BC015211, DB498348
    Consensus CDS
    CCDS6368.1
    UniProtKB/Swiss-Prot
    A8MW92
    UniProtKB/TrEMBL
    Q9H8G4
    Related
    ENSP00000338269.4, ENST00000337920.8
    Conserved Domains (3) summary
    cd04508
    Location:90135
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam12618
    Location:184284
    DUF3776; Protein of unknown function (DUF3776)
    cl17705
    Location:368
    MBT; mbt repeat

RNA

  1. NR_156424.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AF228727, AF230666, BC144654, DA557575, DB498348

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    132775358..132848807
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013513.1XP_016869002.1  PHD finger protein 20-like protein 1 isoform X9

  2. XM_011517075.1XP_011515377.1  PHD finger protein 20-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011515377.1

    Conserved Domains (5) summary
    cd04508
    Location:90135
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd15633
    Location:688733
    PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)
    pfam12618
    Location:214322
    DUF3776; Protein of unknown function (DUF3776)
    pfam16660
    Location:323388
    PHD20L1_u1; PHD finger protein 20-like protein 1
    cl17705
    Location:368
    MBT; mbt repeat
  3. XM_005250931.1XP_005250988.1  PHD finger protein 20-like protein 1 isoform X2

    Conserved Domains (5) summary
    cd04508
    Location:90135
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd15633
    Location:688733
    PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)
    pfam12618
    Location:214322
    DUF3776; Protein of unknown function (DUF3776)
    pfam16660
    Location:323388
    PHD20L1_u1; PHD finger protein 20-like protein 1
    cl17705
    Location:368
    MBT; mbt repeat
  4. XM_011517077.1XP_011515379.1  PHD finger protein 20-like protein 1 isoform X3

    Conserved Domains (5) summary
    cd04508
    Location:90135
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd15633
    Location:687732
    PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)
    pfam12618
    Location:214321
    DUF3776; Protein of unknown function (DUF3776)
    pfam16660
    Location:322387
    PHD20L1_u1; PHD finger protein 20-like protein 1
    cl17705
    Location:368
    MBT; mbt repeat
  5. XM_011517078.1XP_011515380.1  PHD finger protein 20-like protein 1 isoform X4

    Conserved Domains (5) summary
    cd04508
    Location:90135
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd15633
    Location:684729
    PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)
    pfam12618
    Location:210318
    DUF3776; Protein of unknown function (DUF3776)
    pfam16660
    Location:319384
    PHD20L1_u1; PHD finger protein 20-like protein 1
    cl17705
    Location:368
    MBT; mbt repeat
  6. XM_011517079.1XP_011515381.1  PHD finger protein 20-like protein 1 isoform X5

    Conserved Domains (5) summary
    cd04508
    Location:90135
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd15633
    Location:683728
    PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)
    pfam12618
    Location:210317
    DUF3776; Protein of unknown function (DUF3776)
    pfam16660
    Location:318383
    PHD20L1_u1; PHD finger protein 20-like protein 1
    cl17705
    Location:368
    MBT; mbt repeat
  7. XM_011517080.1XP_011515382.1  PHD finger protein 20-like protein 1 isoform X6

    Related
    ENSP00000378788.2, ENST00000395390.6
    Conserved Domains (5) summary
    cd04508
    Location:90135
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd15633
    Location:658703
    PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)
    pfam12618
    Location:184292
    DUF3776; Protein of unknown function (DUF3776)
    pfam16660
    Location:293358
    PHD20L1_u1; PHD finger protein 20-like protein 1
    cl17705
    Location:368
    MBT; mbt repeat
  8. XM_011517081.1XP_011515383.1  PHD finger protein 20-like protein 1 isoform X7

    Conserved Domains (5) summary
    cd04508
    Location:90135
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd15633
    Location:657702
    PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)
    pfam12618
    Location:184291
    DUF3776; Protein of unknown function (DUF3776)
    pfam16660
    Location:292357
    PHD20L1_u1; PHD finger protein 20-like protein 1
    cl17705
    Location:368
    MBT; mbt repeat
  9. XM_011517076.1XP_011515378.1  PHD finger protein 20-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011515378.1

    Conserved Domains (5) summary
    cd04508
    Location:90135
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd15633
    Location:688733
    PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)
    pfam12618
    Location:214322
    DUF3776; Protein of unknown function (DUF3776)
    pfam16660
    Location:323388
    PHD20L1_u1; PHD finger protein 20-like protein 1
    cl17705
    Location:368
    MBT; mbt repeat
  10. XM_017013509.1XP_016868998.1  PHD finger protein 20-like protein 1 isoform X5

    Conserved Domains (5) summary
    cd04508
    Location:90135
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd15633
    Location:683728
    PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)
    pfam12618
    Location:210317
    DUF3776; Protein of unknown function (DUF3776)
    pfam16660
    Location:318383
    PHD20L1_u1; PHD finger protein 20-like protein 1
    cl17705
    Location:368
    MBT; mbt repeat
  11. XM_017013510.1XP_016868999.1  PHD finger protein 20-like protein 1 isoform X6

    Conserved Domains (5) summary
    cd04508
    Location:90135
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd15633
    Location:658703
    PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)
    pfam12618
    Location:184292
    DUF3776; Protein of unknown function (DUF3776)
    pfam16660
    Location:293358
    PHD20L1_u1; PHD finger protein 20-like protein 1
    cl17705
    Location:368
    MBT; mbt repeat
  12. XM_017013511.1XP_016869000.1  PHD finger protein 20-like protein 1 isoform X7

    Conserved Domains (5) summary
    cd04508
    Location:90135
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd15633
    Location:657702
    PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)
    pfam12618
    Location:184291
    DUF3776; Protein of unknown function (DUF3776)
    pfam16660
    Location:292357
    PHD20L1_u1; PHD finger protein 20-like protein 1
    cl17705
    Location:368
    MBT; mbt repeat
  13. XM_011517088.1XP_011515390.1  PHD finger protein 20-like protein 1 isoform X10

    See identical proteins and their annotated locations for XP_011515390.1

    Conserved Domains (4) summary
    cd04508
    Location:90135
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam12618
    Location:214322
    DUF3776; Protein of unknown function (DUF3776)
    pfam16660
    Location:323388
    PHD20L1_u1; PHD finger protein 20-like protein 1
    cl17705
    Location:368
    MBT; mbt repeat
  14. XM_017013516.1XP_016869005.1  PHD finger protein 20-like protein 1 isoform X11

    UniProtKB/TrEMBL
    A0A0A8K9A6
    Related
    ENST00000315808.14
    Conserved Domains (4) summary
    cd04508
    Location:90135
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam12618
    Location:210317
    DUF3776; Protein of unknown function (DUF3776)
    pfam16660
    Location:318383
    PHD20L1_u1; PHD finger protein 20-like protein 1
    cl17705
    Location:368
    MBT; mbt repeat
  15. XM_017013517.1XP_016869006.1  PHD finger protein 20-like protein 1 isoform X12

    UniProtKB/Swiss-Prot
    A8MW92
    Related
    ENSP00000378777.1, ENST00000395379.5
    Conserved Domains (3) summary
    cd04508
    Location:90135
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam12618
    Location:184284
    DUF3776; Protein of unknown function (DUF3776)
    cl17705
    Location:368
    MBT; mbt repeat
  16. XM_017013514.2XP_016869003.1  PHD finger protein 20-like protein 1 isoform X9

RNA

  1. XR_001745535.1 RNA Sequence

  2. XR_001745533.1 RNA Sequence

  3. XR_001745536.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_024878.1: Suppressed sequence

    Description
    NM_024878.1: This RefSeq was permanently suppressed because it represents actually 5' partial CDS and its 5' sequence was intronic sequence.
  2. NM_032205.3: Suppressed sequence

    Description
    NM_032205.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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