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ABHD17B abhydrolase domain containing 17B, depalmitoylase [ Homo sapiens (human) ]

Gene ID: 51104, updated on 25-Nov-2021

Summary

Official Symbol
ABHD17Bprovided by HGNC
Official Full Name
abhydrolase domain containing 17B, depalmitoylaseprovided by HGNC
Primary source
HGNC:HGNC:24278
See related
Ensembl:ENSG00000107362 MIM:617943
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGI-67; C9orf77; FAM108B1
Expression
Ubiquitous expression in brain (RPKM 5.5), duodenum (RPKM 3.6) and 25 other tissues See more
Orthologs
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Genomic context

See ABHD17B in Genome Data Viewer
Location:
9q21.13
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (71862452..71911536, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (74477368..74526109, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene cell migration inducing hyaluronidase 2 Neighboring gene HNF1 motif-containing MPRA enhancer 224 Neighboring gene glucosamine-6-phosphate deaminase 2 pseudogene Neighboring gene chromosome 9 open reading frame 85 Neighboring gene heat shock protein family B (small) member 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables palmitoyl-(protein) hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables palmitoyl-(protein) hydrolase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of protein localization to microtubule IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein localization to endosome IEA
Inferred from Electronic Annotation
more info
 
involved_in protein depalmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein depalmitoylation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein depalmitoylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of dendritic spine maintenance IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of postsynapse organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of protein localization to synapse IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
 
is_active_in endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 
located_in recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
alpha/beta hydrolase domain-containing protein 17B
Names
abhydrolase domain-containing protein 17B
abhydrolase domain-containing protein FAM108B1
epididymis secretory sperm binding protein
family with sequence similarity 108, member B1
protein ABHD17B
NP_001020951.1
NP_057098.2
XP_006717197.2
XP_006717198.1
XP_016870276.1
XP_016870277.1
XP_016870278.1
XP_016870280.1
XP_024303335.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025780.3NP_001020951.1  alpha/beta hydrolase domain-containing protein 17B isoform 2

    See identical proteins and their annotated locations for NP_001020951.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL138751, AL671309
    Consensus CDS
    CCDS35043.1
    UniProtKB/Swiss-Prot
    Q5VST6
    Related
    ENSP00000330222.6, ENST00000333421.7
    Conserved Domains (1) summary
    COG1073
    Location:93285
    FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]
  2. NM_016014.4NP_057098.2  alpha/beta hydrolase domain-containing protein 17B isoform 1

    See identical proteins and their annotated locations for NP_057098.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AF151825, AI564777, BC038390, BG720713, CR746318
    Consensus CDS
    CCDS35042.1
    UniProtKB/Swiss-Prot
    Q5VST6
    Related
    ENSP00000366240.2, ENST00000377041.6
    Conserved Domains (1) summary
    COG1073
    Location:93285
    FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    71862452..71911536 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717134.3XP_006717197.2  alpha/beta hydrolase domain-containing protein 17B isoform X1

    UniProtKB/Swiss-Prot
    Q5VST6
    Conserved Domains (1) summary
    COG1073
    Location:93285
    FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]
  2. XM_017014787.2XP_016870276.1  alpha/beta hydrolase domain-containing protein 17B isoform X1

    UniProtKB/Swiss-Prot
    Q5VST6
    Conserved Domains (1) summary
    COG1073
    Location:93285
    FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]
  3. XM_024447567.1XP_024303335.1  alpha/beta hydrolase domain-containing protein 17B isoform X3

    Conserved Domains (1) summary
    COG1073
    Location:93225
    FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]
  4. XM_017014791.1XP_016870280.1  alpha/beta hydrolase domain-containing protein 17B isoform X3

    Conserved Domains (1) summary
    COG1073
    Location:93225
    FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]
  5. XM_017014788.2XP_016870277.1  alpha/beta hydrolase domain-containing protein 17B isoform X2

    UniProtKB/Swiss-Prot
    Q5VST6
    Conserved Domains (1) summary
    COG1073
    Location:93285
    FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]
  6. XM_017014789.2XP_016870278.1  alpha/beta hydrolase domain-containing protein 17B isoform X2

    UniProtKB/Swiss-Prot
    Q5VST6
    Conserved Domains (1) summary
    COG1073
    Location:93285
    FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]
  7. XM_006717135.2XP_006717198.1  alpha/beta hydrolase domain-containing protein 17B isoform X4

    See identical proteins and their annotated locations for XP_006717198.1

    Conserved Domains (2) summary
    COG1073
    Location:93194
    FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]
    pfam12695
    Location:93201
    Abhydrolase_5; Alpha/beta hydrolase family
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